Faculty Information - Nakamura Hideaki

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Book and thesis

Academic conference presentation

Academic background

Business career

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Research Field

（Last updated : 2021-10-11 11:28:19）

Nakamura Hideaki
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES

Position

■ Book and thesis

1.	2021/09	Article	Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine J Control Release 337,pp.546-556 (Collaboration)
2.	2021/01	Article	Preparation of enzymatically highly active pegylated-D-amino acid oxidase and its application to antitumor therapy. Curr Drug Deliv (Collaboration)
3.	2021/05	Article	De novo filament formation by human hair keratins K85 and K35 follows a filament development pattern distinct from cytokeratin filament networks. FEBS Open Bio 11(5),pp.1299-1312 (Collaboration)
4.	2020/05	Article	Efficient Anticancer Drug Delivery for Pancreatic Cancer Treatment Utilizing Supramolecular Polyethylene-Glycosylated Bromelain ACS Applied Bio Materials 3(5),pp.3005-3014 (Collaboration)
5.	2020/04	Article	Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization. Acta Biomater 106,pp.256-266 (Collaboration)
6.	2019/07	Article	Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid. Molecular Pharmaceutics (Collaboration)
7.	2019/05	Article	In vivo Efficacy and Safety Evaluation of Lactosyl-β-cyclodextrin as a Therapeutic Agent for Hepatomegaly in Niemann-Pick Type C Disease. Nanomaterials 9(5) (Collaboration)
8.	2018/05	Article	The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype. 18(1),pp.519 (Collaboration)
9.	2018	Article	Preparation and in Vitro Analysis of Human Serum Albumin Nanoparticles Loaded with Anthracycline Derivatives. Chem Pharm Bull (Tokyo). 66(4),pp.382-390 (Collaboration)
10.	2017/10	Article	Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate. Eur J Pharm Sci. 106,pp.10-19 (Collaboration)
11.	2017/09	Article	Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer. Biomaterials. 140,pp.162-169 (Collaboration)
12.	2017/04	Article	Hyaluronic Acid-zinc Protoporphyrin IX Conjugates for Photodynamic Antitumor Therapy Journal of Nanomedicine & Nanotechnology (Collaboration)
13.	2016/12	Article	Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin. Mol Pharm. 13(12),pp.4106-4115 (Collaboration)
14.	2016/05	Article	Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect pp.549-557 (Collaboration)
15.	2016/04	Article	N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan. Biochem Biophys Rep. 6,pp.266-274 (Collaboration)
16.	2016/02	Article	pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect Colloids Surf B Biointerfaces 138,pp.128-137 (Collaboration)
17.	2015	Article	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases. Target Oncol (Collaboration)
18.	2015/08	Article	S-Nitrosated human serum albumin dimer as novel nano-EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes. J Control Release 217,pp.1-9 (Collaboration)
19.	2015/03	Article	Synthesis and therapeutic effect of styrene-maleic acid copolymer-conjugated pirarubicin. Cancer Sci 106(3),pp.270-278 (Collaboration)
20.	2015/02	Article	Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice. Eur J Pharm Biopharm 90,pp.90-96 (Collaboration)
21.	2015/01	Article	Development of next-generation macromolecular drugs based on the EPR effect: challenges and pitfalls. Expert Opin Drug Deliv 12(1),pp.53-64 (Collaboration)
22.	2015/03	Article	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin Future Science OA (Collaboration)
23.	2015/01	Article	Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor Eur J Pharm Biopharm 89,pp.259-270 (Collaboration)
24.	2014/10	Article	Enhanced bacterial tumor delivery by modulating the EPR effect and therapeutic potential of Lactobacillus casei J Pharm Sci 103(10),pp.3235-3243 (Collaboration)
25.	2014/08	Article	Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease. J Control Release 187,pp.14-21 (Collaboration)
26.	2014/01	Article	Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage. J Control Release 174,pp.81-87 (Collaboration)
27.	2013/12	Article	Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines. Carcinogenesis 34,pp.2833-2841 (Collaboration)
28.	2013	Article	Characterization of Carotenoid Fatty Acid Esters from the Peels of the Persimmon Diospyros kaki Chem Pharm Bull (Tokyo) 61,pp.666-669 (Collaboration)
29.	2013	Book	Cancer Chemotherapy Fundamentals of Pharmaceutical Nanoscience pp.401-427 (Collaboration)
30.	2012	Article	Protective Role of D -Amino Acid Oxidase Against Staphylococcus aureus Infection. Infect Immun 80,pp.1546-1553 (Collaboration)
31.	2012	Article	Pegylated D -amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite Exp Biol Med 237,pp.703-708 (Collaboration)
32.	2012	Article	HSP32 (HO-1) inhibitor, copoly(styrene-maleic acid)-zinc protoporphyrin IX, a water-soluble micelle as anticancer agent: In vitro and in vivo anticancer effect. Eur. J. Pharm. Biopharm 81,pp.540-547 (Collaboration)
33.	2012	Article	Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors Cancer Sci 103,pp.535-541 (Collaboration)
34.	2011	Article	Therapeutic potential of pegylated hemin for reactive oxygen species-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model. J Pharmacol Exp Ther 339,pp.779-789 (Collaboration)
35.	2011	Article	The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Adv Drug Deliv Rev 63,pp.136-151 (Collaboration)
36.	2011	Article	Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; unique intracellular disintegration of SMA micelles. J Control Release 155,pp.367-375 (Collaboration)
37.	2011	Article	4-Amino-6-hydroxypyrazolo [3,4-d]pyrimidine (AHPP) conjugated PEG micelles : water soluble polymeric xanthine oxidase inhibitor. J Drug Target 19,pp.954-966 (Collaboration)
38.	2009	Article	SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect. J Control Release 135,pp.211-217 (Collaboration)
39.	2008	Article	Targeting of heat shock protein 32 (Hsp32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myeloid leukemia: a novel approach to overcome resistance against imatinib. Blood 111,pp.2200-2210 (Collaboration)
40.	2008	Article	Oxystress inducing antitumor therapeutics via tumor-targeted delivery of PEG-conjugated D-amino acid oxidase. Int J Cancer 122,pp.1135-1144 (Collaboration)
41.	2007	Article	Tumor-targeted induction of oxystress for cancer therapy. J Drug Target 15,pp.475-486 (Collaboration)
42.	2006	Article	SUMO down-regulates the activity of Elf4/myeloid Elf-1-like factor. Biochem Biophys Res Commun 348,pp.880-888 (Collaboration)
43.	2005	Article	Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells. FEBS Lett 579,pp.2811-2816 (Collaboration)
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■ Academic conference presentation

1.	2014/05	Improved pharmacokinetics and antitumor activity of poly(N-(2-hydroxypropyl)methacrylamide) conjugates of pirarubicin (10th International Symposium Polymer Therapeutics.)
2.	2013	Double selective antitumor action of pirarubicin-conjugated N-(2-hydroxypropyl) methacrylamide copolymer (Annual Meeting & Exposition of the Controlled Release Society)

■ Academic background

1.	2000/04～2004/03	Faculty of Pharmaceutical Science, Kumamoto University, Graduated,
2.	2004/04～2006/03	〔Master Course〕, Kumamoto University, Completed,

■ Business career

1.	2006/04～2013/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2.	2013/04～2016/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

■ researchmap Researcher code

B000236204

■ E-Mail Address

■ Research Field

2012

First Most Interesting Poster Communication

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