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    (Last updated : 2023-01-23 09:44:57)
  Takechi Shinji
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
   Position  
■ Book and thesis
1. 2022/09 Article Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells The Journal of Toxicological Sciences pp.381-387 (Collaboration)  Link
2. 2022/02 Article Use of a baculovirus-mammalian cell expression-system for expression of drug-metabolizing enzymes: optimization of infection with a focus on cytochrome P450 3A Frontiers in Pharmacology 13 (Collaboration)  Link
3. 2020/10 Article The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35(5),pp.466-474 (Collaboration)  Link
4. 2020/07 Article The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. The Journal of Toxicological Sciences 45(7),pp.401-409 (Collaboration)  Link
5. 2019/10 Article β-Naphthoflavone , an exogenous ligand of aryl hydrocarbon receptor , disrupts zinc homeostasis in human hepatoma HepG2 cells. The Journal of Toxicological Sciences 44(10),pp.711-720 (Collaboration)  Link
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■ Academic conference presentation
1. 2010/12 Identification of a Dihydropyrazine-Glutathione Adduct (Biochemistry and Molecular Biology 2010 (BMB2010))
2. 2011/07 Development synthesis of dihydropyrazines having DNA strand-breakage activity (The 17th European Symposium on Organic Chemistry)
3. 2017/09 New familial amyotrophic lateral sclerosis with benign progression and myoclonus in lower extremities (The XXIII World Congress of Neurology)
4. 2017/09 Long-term observation of benign familial amyotrophic lateral sclerosis (FALS) with a H46R mutation in superoxide dismutase1 gene (SOD1) (The XXIII World Congress of Neurology)
■ Business career
1. 2012/04~ /(DC)Division of Pharmaceutical Sciences
2. 2012/04~ Graduate School of Engineering /Division of Applied Chemistry
3. 2011/04~ SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
4. 2007/04~2011/03 SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
5. 2005/04~2007/03 SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
■ Home Page
   Laboratory of Hygienic Chemistry
■ Present specialized field
Molecular biology, Others, Pharmaceutical hygiene and biochemistry, Hygiene and public health: including laboratory approach 
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