Faculty Information - Takechi Shinji

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（Last updated : 2023-01-23 09:44:57）

Takechi Shinji
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES

Position

■ Book and thesis

1.	2022/09	Article	Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells The Journal of Toxicological Sciences pp.381-387 (Collaboration)
2.	2022/02	Article	Use of a baculovirus-mammalian cell expression-system for expression of drug-metabolizing enzymes: optimization of infection with a focus on cytochrome P450 3A Frontiers in Pharmacology 13 (Collaboration)
3.	2020/10	Article	The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35(5),pp.466-474 (Collaboration)
4.	2020/07	Article	The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. The Journal of Toxicological Sciences 45(7),pp.401-409 (Collaboration)
5.	2019/10	Article	β-Naphthoflavone , an exogenous ligand of aryl hydrocarbon receptor , disrupts zinc homeostasis in human hepatoma HepG2 cells. The Journal of Toxicological Sciences 44(10),pp.711-720 (Collaboration)
6.	2019/07	Article	Atypical Familial Amyotrophic Lateral Sclerosis with Slowly Progressing Lower Extremities-predominant Late-onset Muscular Weakness and Atrophy. Internal Medicine 58(13),pp.1851-1858 (Collaboration)
7.	2016/11	Article	Nrf2-ARE-dependent alterations in zinc transporter mRNA expression in HepG2 cells. PLoS ONE 11(11),pp.e0166100 (Collaboration)
8.	2015/08	Article	Identification of dihydropyrazine-glutathione adducts. J. Toxicol. Sci. 40(4),pp.495-500 (Collaboration)
9.	2014/08	Article	The effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine. J. Toxicol. Sci. 39(4),pp.601-608 (Collaboration)
10.	2013/06	Article	Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochimica et Biophysica Acta 1830(6),pp.3616-3624 (Collaboration)
11.	2012/10	Article	Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells. J. Toxicol. Sci. 37(5),pp.1065-1069 (Collaboration)
12.	2012/05	Article	Generation of radical species from dihydropyrazines having DNA strand-breakage activity and other characteristics. Chem. Pharm. Bull. 60(5),pp.639-646 (Collaboration)
13.	2011/04	Article	2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries J. Toxicol. Sci. 36(2),pp.221-229 (Collaboration)
14.	2011/04	Article	Glutathione depression by dihydropyrazine derivative. J. Toxicol. Sci. 36(2),pp.231-235 (Collaboration)
15.	2011/01	Article	The effects of tetraazaindene, derived from dihydropyrazine, to break DNA strands and inhibit bacterial growth. J. Basic Appl. Chem. 1,pp.1-7 (Collaboration)
16.	2010/07	Article	Latent Enamine functionality of 5-methyl-2,3-dihydropyrazines. Chem. Pharm. Bull. 58(7),pp.922-927 (Collaboration)
17.	2010/06	Article	Phenyl-substituted dihydropyrazines with DNA strand-breakage activity Chem. Pharm. Bull. 58(6),pp.825-828 (Collaboration)
18.	2010/03	Article	Dihydropyrazine-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase. Biol. Pharm. Bull 33(3),pp.379-383 (Collaboration)
19.	2009/12	Article	Tetraazaindenes derived from dihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull 57(12),pp.1371-1375 (Collaboration)
20.	2009/02	Article	Oxidative stress induced by a dihydropyrazine derivative. BioI. Pharm. Bull 32(2),pp.186-189 (Collaboration)
21.	2007/09	Article	Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species on Escherichia coli. Biol. Pharm. Bull. 30(9),pp.1663-1667 (Collaboration)
22.	2006/01	Article	Mutation spectrum induced by dihydropyrazines in Escherichia coli. Biol. Pharm. Bull. 29(1),pp.17-20 (Collaboration)
23.	2005/07	Article	The role of dihydropyrazines upon the addition of Copper (II) in an accelerated death of Escherichia coli. Biol. Pharm. Bull. 28(7),pp.1161-1164 (Collaboration)
24.	2005/03	Article	Radical species in DNA strand-cleavage caused by dihydropyrazines. Biol.Pharm. Bull. 28(3),pp.419-423 (Collaboration)
25.	2004/10	Article	Familial amyotrophic lateral sclerosis with His46Arg mutation in Cu/Zn superoxide dismutase presenting characteristic clinical features and Lewy body-like hyaline inclusions. J. Neurol. Sci. 225(1-2),pp.19-25 (Collaboration)
26.	2004/05	Article	Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity. Mutat. Res. 560(1),pp.49-55 (Collaboration)
27.	2002/11	Article	Chicken HDAC2 down-regulates IgM light chain gene promoter activity. Biochem Biophys Res Commun. 299(2),pp.263-267 (Collaboration)
28.	2002/09	Article	Cloning and characterization of the chick Oct binding factor OBF-1. Biochim Biophys Acta. 1577(3),pp.466-470 (Collaboration)
29.	2002/05	Article	Clinical features and neuropathological findings of familial amyotrophic lateral sclerosis with a His46Arg mutation in Cu/Zn superoxide dismutase. J Neurol Sci. 197(1-2),pp.73-78 (Collaboration)
30.	2000/08	Article	Two novel mutations in the adrenoleukodystrophy gene in two unrelated Japanese families and the long-term effect of bone marrow transplantation. J Neurol Sci. 177(2),pp.131-138 (Collaboration)
31.	2000/03	Article	CALNUC (nucleobindin) is localized in the Golgi apparatus in insect cells. Eur J Cell Biol. 79(3),pp.208-217 (Collaboration)
32.	1999/12	Article	Sas3 is a histone acetyltransferase and requires a zinc finger motif. Biochem Biophys Res Commun. 266(2),pp.405-410 (Collaboration)
33.	1996/04	Article	Organizatoin of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences. DNA Res. 3(2),pp.95-99 (Collaboration)
34.	1996/02	Article	Molecular structure of the transposable element ninja in Drosophila simulans. Genes Genet Syst. 71(1),pp.1-8 (Collaboration)
35.	1995/10	Article	Initiation of unidirectional ColE2 DNA replication by a unique priming mechanism. Nucleic Acids Res. 23(20),pp.4196-4201 (Collaboration)
36.	1995/10	Article	Primer RNA synthesis by plasmid-specified Rep protein for initiation of ColE2 DNA replication. EMBO J. 14(20),pp.5141-5147 (Collaboration)
37.	1994/07	Article	Control of ColE2 plasmid replication: negative regulation of the expression of the plasmid-specified initiator protein, Rep, at a posttranscriptional step. Mol Gen Genet. 244(1),pp.41-48 (Collaboration)
38.	1994/07	Article	Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA. Mol Gen Genet. 244(1),pp.49-56 (Collaboration)
39.	1994/03	Article	Exogenous histone H1 injection into mitotic cells disrupts synchronous progression of mitotic events by delaying chromosome decondensation. J Cell Sci. 107,pp.693-701 (Collaboration)
40.	1993/09	Article	Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair. Gene 131(2),pp.193-199 (Collaboration)
41.	1993/04	Article	The chicken histone gene family. Comp Biochem Physiol B. 104(4),pp.635-639 (Collaboration)
42.	1993/01	Article	Nucleotide sequence of the cDNA encoding mouse thyloid peroxidase. Gene 123(2),pp.289-290 (Collaboration)
43.	1991/12	Article	Nucleotide sequences of two members of the chicken H4 histone-encoding gene family. Gene 108(2),pp.311-312 (Collaboration)
44.	2015/08	Article	3-hydro-2,2,5,6-tetramethylpyrazine: a novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells. Arch. Biochem. Biophys. 580,pp.57-63 (Collaboration)
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■ Academic conference presentation

1.	2010/12	Identification of a Dihydropyrazine-Glutathione Adduct (Biochemistry and Molecular Biology 2010 (BMB2010))
2.	2011/07	Development synthesis of dihydropyrazines having DNA strand-breakage activity (The 17th European Symposium on Organic Chemistry)
3.	2017/09	New familial amyotrophic lateral sclerosis with benign progression and myoclonus in lower extremities (The XXIII World Congress of Neurology)
4.	2017/09	Long-term observation of benign familial amyotrophic lateral sclerosis (FALS) with a H46R mutation in superoxide dismutase1 gene (SOD1) (The XXIII World Congress of Neurology)

■ Business career

1.	2012/04～	/(DC)Division of Pharmaceutical Sciences
2.	2012/04～	Graduate School of Engineering /Division of Applied Chemistry
3.	2011/04～	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
4.	2007/04～2011/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
5.	2005/04～2007/03	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

■ Home Page

Laboratory of Hygienic Chemistry

■ Present specialized field

Molecular biology, Others, Pharmaceutical hygiene and biochemistry, Hygiene and public health: including laboratory approach

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