Faculty Information - Ueda Naoko

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（Last updated : 2023-01-19 12:06:58）

Ueda Naoko
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES

Position

■ Book and thesis

1.	2021/04	Article	Glycosylation decreases aggregation and immunogenicity of adalimumab fab secreted from Pichia pastoris J.Biochem 169(4),pp.435-443 (Collaboration)
2.	2020/03	Article	Discovery of the Gene Encoding a Novel Small Serum Protein (SSP) of Protobothrops flavoviridis and the Evolution of SSPs Toxins 12,pp.177 (Collaboration)
3.	2020/03	Article	C-Terminal Cysteine PEGylation of Adalimumab Fab With an Engineered Interchain SS Bond Bio pharm bull 43(3),pp.418-423 (Collaboration)
4.	2019/10	Article	Alternative mRNA splicing in three venom families underlying a possible production of divergent venom proteins of the Habu snake, Protobothrops flavoviridis Toxins(Basel) 11,pp.581 (Collaboration)
5.	2019/07	Article	Unique Structure (Construction and Configuration) and Evolution of the Array of Small Serum Protein Genes of Protobothrops flavoviridis Snake Biosci rep 39(7),pp.560 (Collaboration)
6.	2019/02	Article	SDS-induced oligomerization of Lys⁴⁹-phospholipase A₂ from snake venom Sci Rep. (Collaboration)
7.	2018/09	Article	Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab. Biochem Biophys Res Commun. 503(2),pp.752-756 (Collaboration)
8.	2018/07	Article	The habu genome reveals accelerated evolution of venom protein genes. Sci Rep. 8(1),pp.11300 (Collaboration)
9.	2018/01	Article	A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab. 495(1),pp.7-11 (Collaboration)
10.	2015/08	Article	Interisland variegation of venom [Lys⁴⁹]phospholipase A₂ isozyme genes in Protobothrops genus snakes in the southwestern islands of Japan. Toxicon (Collaboration)
11.	2014/12	Article	The finding of a group IIE phospholipase A₂ gene in a specified segment of Protobothrops flavoviridis genome and its possible evolutionary relationship to group IIA phospholipase A2 genes. Toxins(Basel) (Collaboration)
12.	2014/12	Article	Epithelium specific ETS transcription factor, ESE-3, of Protobothrops flavoviridis snake venom gland transactivates the promoters of venom phospholipase A₂ isozyme genes Toxicon 92,pp.133-139 (Collaboration)
13.	2014/08	Article	Discovery of a novel vascular endothelial growth factor (VEGF) with no affinity to heparin in Gloydius tsushimaensis venom Toxicon : official journal of the International Society on Toxinology 86,pp.107-115 (Collaboration)
14.	2013/12	Article	Suppression of severe lesions, myonecrosis and hemorrhage, caused by Protobothrops flavoviridis venom with its serum proteins 76,pp.197 (Collaboration)
15.	2013/01	Article	Structual characteristics and evolution of the Protobothrops elegans pancreatic phospholipase A₂ gene in contrast with those of Protobothrops genus venom phospholipase A₂ genes. Biosci. Biotechnol. Biochem 77,pp.97-102 (Collaboration)
16.	2012/06	Article	Comparative analysis of cells and proteins of pumplin plants for the control of fruit size. J. Biosci. Bioeng. 114,pp.334-341 (Collaboration)
17.	2012/03	Article	Structural characteristics and evolution of a novel venom phospholipase A₂ gene from Protobothrops flavoviridis. Biosci. Biotech. Biochem. 76,pp.551-558 (Collaboration)
18.	2011/05	Article	A [Lys⁴⁹] phospholipase A₂from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma membrane rupture in human leukemia cells. Biosci. Biotech. Biochem. 75,pp.864-870 (Collaboration)
19.	2011/03	Article	Identification and evolution of venom phospholipase A₂ inhibitors from Protobothrops elegans serum. Biosci. Biotech. Biochem. 75,pp.480-488 (Collaboration)
20.	2010/04	Article	Unique structural characteristics and evolution of a cluster of venom phospholipase A₂ isozyme genes of Protobothrops flavoviridis snake. Gene 461,pp.15-25 (Collaboration)
21.	2009/09	Article	Island specific expression of a novel [Lys ⁴⁹ ]phospholipase A₂ (BPIII) in Protobothrops flavoviridis venom in Amami-Oshima,Japan Toxicon 54,pp.399-407 (Collaboration)
22.	2008/03	Article	Identification of the B subtype of gamma-phospholipase A₂ Inhibitor from Protobothrops flavoviridis serum and molecular evolution of snake serum phospholipase A₂Inhibitors. J. Mol. Evol. 66,pp.298-307 (Collaboration)
23.	2008/02	Article	Immunocytochemical demonstration of polyamines in nucleoli and nuclei. Histochem. Cell Biol 129,pp.659-665 (Collaboration)
24.	2003/12	Article	Molecular evolution of myotoxic phospholipases A₂ from snake venom. Toxicon : official journal of the International Society on Toxinology 42(8),pp.841-54 (Collaboration)
25.	2003/11	Article	Interisland mutation of a novel phospholipase A₂ from Trimeresurus flavoviridis venom and evolution of Crotalinae group II phospholipases A₂. Journal of molecular evolution 57(5),pp.546-54 (Collaboration)
26.	2003	Article	Case report: Extraocular muscle paresis caused by snakebite. The Kobe journal of medical sciences 49(1-2),pp.11-5 (Collaboration)
27.	2002/09	Article	Flavoxobin, a serine protease from Trimeresurus flavoviridis (habu snake) venom, independently cleaves Arg726-Ser727 of human C3 and acts as a novel, heterologous C3 convertase. Immunology 107(1),pp.111-7 (Collaboration)
28.	2001/10	Article	Trimeresurus flavoviridis (habu snake) venom induces human erythrocyte lysis through enzymatic lipolysis, complement activation and decreased membrane expression of CD55 and CD59. Pharmacology & toxicology 89(4),pp.188-94 (Collaboration)
29.	2002	Book	Accelarated and regional evolution of snake venom gland isozymes Perspectives in Molecular Toxinology pp.387-400 (Collaboration)
30.	1998/08	Article	Nucleotide sequence of the gene encoding the precursor protein of pepstatin insensitive acid protease B, scytalidopepsin B, from Scytalidium lignicolum Biosci Biotechnol Biochem 62,pp.1637-1639 (Collaboration)
31.	1997/08	Article	Glutathione-independent formaldehyde dehydrogenase from pseudomonas putida: Survey of functional groups with special regard for cysteine residues Biosci Biotechnol Biochem. 61,pp.1354-1357 (Collaboration)
32.	1996/07	Article	Nucleotide sequence of the gene encoding pepstatin-insensitive acid protease B, scytalidopepsin B, of Scytalidium lignicolum. Biosci Biotechnol Biochem. 60,pp.1210-1211 (Collaboration)
33.	1996/06	Article	DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes 271,pp.13816-13820 (Collaboration)
34.	1996/06	Article	Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins 272,pp.1644 (Collaboration)
35.	1995/10	Article	Lysine-49-phospholipases A2 from Trimeresurus flavoviridis venom are membrane-acting enzymes 118,pp.1037-1044 (Collaboration)
36.	1995/08	Article	Regulation of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs 23,pp.3041-3049 (Collaboration)
37.	1995/01	Article	Trimeresurus flavoviridis venom gland phospholipase A2 isozymes genes have evolved via accelerated substitutions 8,pp.40-46 (Collaboration)
38.	1993/01	Article	Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes 90,pp.5964-5968 (Collaboration)
39.	1993/08	Article	Purification, sequencing and characterization of single amino acid-substituted phospholipase A2 isozymes from Trimeresurus gramineus (green habu snake) venom. 31,pp.957-967 (Collaboration)
40.	1992/11	Article	Sequence determination and characterization of a phospholipase A2 isozyme from Trimeresurus gramineus (green habu snake) venom. 30,pp.1331-1341 (Collaboration)
41.	1992/10	Article	Refolding of Trimeresurus flavoviridis phospholipase A2 65(10),pp.2655-2659 (Collaboration)
42.	1992/09	Article	Unusually high conservation of untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes. Proc Natl Acad Sci USA 89,pp.8557-8561 (Collaboration)
43.	1992/08	Article	Validity of putative calcium binding loops of photoprotein aequorin 307,pp.272-274 (Collaboration)
44.	1990/11	Article	Cloning and sequence analysis of cDNA for Trimeresurus flavoviridis phospholipase A2, and consequent revision of the amino acid sequence. J. Biochem 10,pp.816-821 (Collaboration)
45.	1990/03	Article	Purification and amino acid sequence of basic protein II, a lysine-49-phospholipase A2 with low activity, from Trimeresurus flavoviridis venom. J Biochem 107,pp.400-408 (Collaboration)
46.	1989/12	Article	Investigation of an active site histidine-aspartate couple in Trimeresurus flavoviridis phospholipase A J Biochem 106,pp.1054-1058 (Collaboration)
47.	1988/06	Article	Transition of environmental polarity of tyrosine-76 of Trimeresurus flavoviridis phospholipase A2 upon active site ligand binding. J Mol Recognit. 1,pp.124-129 (Collaboration)
48.	1988/01	Article	Tryptophan residue essential for activity of Naja naja atra phospholipase A2. J Biochem. 103,pp.156-161 (Collaboration)
49.	1987/12	Article	Purification and characterization of phospholipase A₂ from Trimeresurus gramineus venom. J Biochem. 102,pp.1441-1449 (Collaboration)
50.	1986/12	Article	Interactions of Trimeresurus flavoviridis phospholipase A2 and its N-terminal octapeptide-removed and p-bromophenacylated derivatives with acridine and anilinonaphthalene dyes. J Biochem. 100,pp.1551-1560 (Collaboration)
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■ Academic conference presentation

1.	2020/09	Membrane recognition mechanism of phospholipase A2 from habu snake venom revealed by high-speed AFM (HS-AFM)
2.	2019/09	Habu snake (Protobothrops flavoviridis) genome study: Genomic architecture implicated in the multiplication and accelerated evolution of venom protein (EMBO\|EMBL Symposium)
3.	2018/09	Whole Genome Sequencing of a Japanese Endemic Pit Viper, Habu, Protobothrops flavoviridis Reveals Accelerated Evolution of Venom Protein Genes Enriched in Microchromosomal Regions. (The 19th Congress of the European Section of the International Society of Toxinology)

■ Business career

1.	2006/04～	SOJO UNIVERSITY FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
2.	2005/04～2006/03	SOJO UNIVERSITY FACULTY OF BIOTECHNOOLOGY AND LIFE SCIENCE Department of Applied Life Science
3.	2004/04～	Graduate School of Engineering /(DC)Division of Applied Life Science
4.	2004/04～	Graduate School of Engineering /Division of Applied Life Science
5.	2000/04～2005/03	SOJO UNIVERSITY FACULTY OF ENGINEERING
6.	1997/04～2000/03	SOJO UNIVERSITY FACULTY OF ENGINEERING
7.	1995/04～1997/03	SOJO UNIVERSITY FACULTY OF ENGINEERING
8.	1991/04～1995/03	Visiting fellow
9.	1989/04～1991/03	Special researcher of the Japan Society for the Promotion of Science
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■ Home Page

http://www.ph.sojo-u.ac.jp/~nakamura/homepage/laboratory%20of%20biological%20chemistry.html

■ Present specialized field

Molecular biology, Applied biochemistry , Chemistry and chemical methodology of biomolecules (Key Word：Molecular Biology, Biochemistry)

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