イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2007/11
形態種別 原著論文
査読 査読有り
標題 Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.
執筆形態 共著
掲載誌名 Carbohydrate research
掲載区分国外
巻・号・頁 342(15),pp.2182-91
著者・共著者 Miyashita Hiroyuki, Ikeda Tsuyoshi, Nohara Toshihiro
概要 Alpha-L-rhamnopyranosyl-(1-->4)-[alpha-L-rhamnopyranosyl-(1-->2)]-beta-D-glucopyranose (chacotriose) is the oligosaccharide moiety of dioscin. Chacotriosyl trichloroacetimidate was synthesized from d-glucose and l-rhamnose, and glycosylated to mevalonate (diosgenin, cholesterol, and glycyrrhetic acid) to yield dioscin and neosaponins. In order to simplify the structure of the aglycone part, the mevalonate moiety was replaced with double-chain neoglycolipids that mimicked glycosyl ceramides. A cytotoxicity test revealed the importance of the glycosidic linkage of the naturally occurring beta-form and that dioscin and the neoglycolipid with the longest chain showed a moderate activity.
DOI 10.1016/j.carres.2007.06.008
ISSN 0008-6215
PMID 17655835