イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2017/02
形態種別 原著論文
査読 査読有り
標題 Inhibition of gingipains and Porphyromonas gingivalis growth and biofilm formation by prenylated flavonoids
執筆形態 共著
掲載誌名 J. Periodontal Res.
掲載区分国外
出版社・発行元 Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
巻・号・頁 52(1),pp.89-96
著者・共著者 Kariu T., Nakao R., Ikeda T., Imamura T.
概要 RESULTS:
We isolated 17 prenylated flavonoids (Limonianin, Epimedokoreanin B, etc.) from Epimedium species. We found that some prenylated flavonoids inhibited gingipain activity in a non-competitive manner with Ki values at μm order. The prenylated flavonoids also hindered growth and biofilm formation of P. gingivalis, in a manner independent of gingipain inhibition by the compounds.

CONCLUSION:
The results indicated an inhibitory effect of the prenylated flavonoids against P. gingivalis and would provide useful information for future development of periodontitis treatment that suppresses gingipains, P. gingivalis growth and biofilm formation.