イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2019/07
形態種別 原著論文
標題 A natural anti-periodontitis agent, epimedokoreanin B, inhibits virulence activities of gingipains from Porphyromonas gingivalis.
執筆形態 共著
掲載誌名 Bioscience, biotechnology, and biochemistry
掲載区分国外
巻・号・頁 83(7),pp.1382-1384
著者・共著者 Kariu Toru, Ikeda Tsuyoshi, Nakashima Keisuke, Potempa Jan, Imamura Takahisa
概要 Gingipains are potent virulence cysteine proteases secreted by Porphyromonas gingivalis, a major pathogen of periodontitis. We previously reported that epimedokoreanin B inhibits the activities of gingipains. In this report, we show that epimedokoreanin B inhibits the virulence of gingipains-containing P. gingivalis culture supernatants, indicating the potential use of this prenylated flavonoid as a new agent to combat against periodontal pathogens.
DOI 10.1080/09168451.2019.1597615
ISSN 1347-6947
PMID 30912703