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Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES /(DC)Division of Pharmaceutical Sciences, Position |
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| Language | English |
| Publication Date | 2018/01 |
| Type | |
| Title | Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation. |
| Contribution Type | |
| Journal | Journal of clinical and experimental hematopathology : JCEH |
| Journal Type | Another Country |
| Volume, Issue, Page | 58(1),pp.17-23 |
| Author and coauthor | Fujiwara Yukio, Saito Yoichi, Shiota Takuya, Cheng Pan, Ikeda Tsuyoshi, Ohnishi Koji, Takeya Motohiro, Komohara Yoshihiro |
| Details | In the present study, we searched for natural compounds that regulate the CD169-positive phenotype in macrophages to identify potential new anti-cancer agents targeting macrophage activation. Among 50 natural compounds, aculeatiside A, naringin, and onionin A significantly induced the CD169-positive phenotype in human monocyte-derived macrophages. These compounds also induced CD169 overexpression and secretion of inflammatory cytokines, including interleukin (IL)-1β and IL-12, in murine macrophages. Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1β, IL12, and CD169 in regional lymph nodes in mice. These findings suggest aculeatiside A and naringin may enhance anti-tumor immune responses by inducing CD169-positive macrophages in lymph nodes. |
| DOI | 10.3960/jslrt.17032 |
| ISSN | 1880-9952 |
| PMID | 29553092 |