Ikeda Tsuyoshi
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
     /(DC)Division of Pharmaceutical Sciences,
Language English
Publication Date 2018/01
Title Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation.
Contribution Type
Journal Journal of clinical and experimental hematopathology : JCEH
Journal TypeAnother Country
Volume, Issue, Page 58(1),pp.17-23
Author and coauthor Fujiwara Yukio, Saito Yoichi, Shiota Takuya, Cheng Pan, Ikeda Tsuyoshi, Ohnishi Koji, Takeya Motohiro, Komohara Yoshihiro
Details In the present study, we searched for natural compounds that regulate the CD169-positive phenotype in macrophages to identify potential new anti-cancer agents targeting macrophage activation. Among 50 natural compounds, aculeatiside A, naringin, and onionin A significantly induced the CD169-positive phenotype in human monocyte-derived macrophages. These compounds also induced CD169 overexpression and secretion of inflammatory cytokines, including interleukin (IL)-1β and IL-12, in murine macrophages. Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1β, IL12, and CD169 in regional lymph nodes in mice. These findings suggest aculeatiside A and naringin may enhance anti-tumor immune responses by inducing CD169-positive macrophages in lymph nodes.
DOI 10.3960/jslrt.17032
ISSN 1880-9952
PMID 29553092