イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2016/06
形態種別 原著論文
査読 査読有り
標題 Eucommia ulmoides extracts prevent the formation of advanced glycation end products.
執筆形態 共著
掲載誌名 Food & function
掲載区分国外
巻・号・頁 7(6),pp.2566-73
著者・共著者 Sugawa Hikari, Ohno Rei-Ichi, Shirakawa Jun-Ichi, Nakajima Akari, Kanagawa Amane, Hirata Tetsuya, Ikeda Tsuyoshi, Moroishi Narumi, Nagai Mime, Nagai Ryoji
概要 In this study, we measured the inhibitory effects of several Eucommia ulmoides extracts on the formation of AGEs, N(ε)-(carboxymethyl)lysine (CML) and N(ω)-(carboxymethyl)arginine (CMA). Although a crude extract obtained from E. ulmoides bark is widely used as herbal medicine, E. ulmoides leaf extract (ELE) inhibited CML and CMA formation more effectively during the incubation of gelatin with ribose. Therefore, the inhibitory effects of compounds present in ELE on CML and CMA formation were studied. As a result, isoquercetin showed the strongest inhibitory effect of all the tested ELE components. These results indicate that the oral intake of ELE may inhibit the formation of AGEs, thereby ameliorating age-related diseases.
DOI 10.1039/c5fo01563d
ISSN 2042-650X
PMID 27080730