イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2016/04
形態種別 原著論文
査読 査読有り
標題 Two new prenylflavonoids from Epimedii Herba and their inhibitory effects on advanced glycation end-products.
執筆形態 共著
掲載誌名 Journal of natural medicines
掲載区分国外
巻・号・頁 70(2),pp.290-5
著者・共著者 Nakashima Keisuke, Miyashita Hiroyuki, Yoshimitsu Hitoshi, Fujiwara Yukio, Nagai Ryoji, Ikeda Tsuyoshi
概要 In the present study, the MeOH extract of Epimedii Herba (EH; aerial parts of Epimedium spp.) was found to inhibit the formation of N (ε) -(carboxymethyl)lysine (CML) and N (ω) -(carboxymethyl)arginine (CMA) during incubation of collagen-derived gelatin with ribose. Furthermore, compounds with inhibitory effects against CML and CMA formation were isolated from EH. Two new prenylflavonoids (compounds 1 and 2) and two known compounds (3 and 4) were found to significantly inhibit the formation of both CML and CMA; compound 4 (epimedokoreanin B) had the strongest inhibitory effect of the isolated compounds. These data suggest that epimedokoreanin B could prevent clinical complications of diabetes by inhibiting AGEs.
DOI 10.1007/s11418-015-0962-0
ISSN 1861-0293
PMID 26758618