Ikeda Tsuyoshi
   Department   SOJO UNIVERSITY  Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES
     /(DC)Division of Pharmaceutical Sciences,
Language English
Publication Date 2016/04
Peer Review Peer reviewed
Title Two new bicyclic sulfoxides from Welsh onion.
Contribution Type
Journal Journal of natural medicines
Journal TypeAnother Country
Volume, Issue, Page 70(2),pp.260-5
Author and coauthor Nohara Toshihiro, Fujiwara Yukio, Ikeda Tsuyoshi, Murakami Kotaro, Ono Masateru, El-Aasr Mona, Nakano Daisuke, Kinjo Junei
Details Newly identified bicyclic sulfoxides, welsonins A1 (1) and A2 (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1 (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.
DOI 10.1007/s11418-015-0947-z
ISSN 1861-0293
PMID 26676612