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Ikeda Tsuyoshi
Department SOJO UNIVERSITY Department of Pharmaceutical Sciences, FACULTY OF PHARMACEUTICAL SCIENCES /(DC)Division of Pharmaceutical Sciences, Position |
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| Language | English |
| Publication Date | 2016/04 |
| Type | |
| Peer Review | Peer reviewed |
| Title | Two new bicyclic sulfoxides from Welsh onion. |
| Contribution Type | |
| Journal | Journal of natural medicines |
| Journal Type | Another Country |
| Volume, Issue, Page | 70(2),pp.260-5 |
| Author and coauthor | Nohara Toshihiro, Fujiwara Yukio, Ikeda Tsuyoshi, Murakami Kotaro, Ono Masateru, El-Aasr Mona, Nakano Daisuke, Kinjo Junei |
| Details | Newly identified bicyclic sulfoxides, welsonins A1 (1) and A2 (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1 (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages. |
| DOI | 10.1007/s11418-015-0947-z |
| ISSN | 1861-0293 |
| PMID | 26676612 |