イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2016/04
形態種別 原著論文
査読 査読有り
標題 Two new bicyclic sulfoxides from Welsh onion.
執筆形態 共著
掲載誌名 Journal of natural medicines
掲載区分国外
巻・号・頁 70(2),pp.260-5
著者・共著者 Nohara Toshihiro, Fujiwara Yukio, Ikeda Tsuyoshi, Murakami Kotaro, Ono Masateru, El-Aasr Mona, Nakano Daisuke, Kinjo Junei
概要 Newly identified bicyclic sulfoxides, welsonins A1 (1) and A2 (2), were isolated from acetone extracts of the bulbs of the Welsh onion (Allium fistulosum). In this study, the structures of 1 and 2, which are tetrahydrothiophene-S-oxide derivatives, were characterized by spectroscopic analysis. These compounds appeared to be derived from the coupling of 1-propenyl sulfenic acid and uronic acid. Welsonin A1 (1) showed the potential to suppress tumor-cell proliferation by inhibiting the polarization of alternatively activated M2 macrophages.
DOI 10.1007/s11418-015-0947-z
ISSN 1861-0293
PMID 26676612