イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2012/04
形態種別 原著論文
標題 Purification and characterization of HSP-inducers from Eupatorium lindleyanum.
執筆形態 共著
掲載誌名 Biochemical pharmacology
掲載区分国外
巻・号・頁 83(7),pp.909-22
著者・共著者 Yamashita Yasuhiro, Ikeda Tsuyoshi, Matsuda Minoru, Maji Daisuke, Hoshino Tatsuya, Mizushima Tohru
概要 Here we report the purification of eupalinolide A and B (EA and EB) from E. lindleyanum, and describe their actions as HSP-inducers. EA and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability. Treatment of cells with EA or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the EA- or EB-mediated induction of HSP70 expression.
In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin. These results suggest that EA and EB could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.
DOI 10.1016/j.bcp.2011.12.040
ISSN 1873-2968
PMID 22245466