所属 崇城大学 薬学部 薬学科 崇城大学大学院 薬学研究科 薬学専攻 職種 教授
|標題||Purification and characterization of HSP-inducers from Eupatorium lindleyanum.|
|著者・共著者||Yamashita Yasuhiro, Ikeda Tsuyoshi, Matsuda Minoru, Maji Daisuke, Hoshino Tatsuya, Mizushima Tohru|
|概要||Here we report the purification of eupalinolide A and B (EA and EB) from E. lindleyanum, and describe their actions as HSP-inducers. EA and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability. Treatment of cells with EA or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the EA- or EB-mediated induction of HSP70 expression.
In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin. These results suggest that EA and EB could be beneficial for use in cosmetics and medicines as a consequence of their inhibitory action on UV-induced skin damage and melanin production.