イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2011/05
形態種別 原著論文
査読 査読有り
標題 Triterpenoids isolated from Zizyphus jujuba inhibit foam cell formation in macrophages.
執筆形態 共著
掲載誌名 Journal of agricultural and food chemistry
掲載区分国外
巻・号・頁 59(9),pp.4544-52
著者・共著者 Fujiwara Yukio, Hayashida Akinori, Tsurushima Keiichiro, Nagai Ryoji, Yoshitomi Makiko, Daiguji Norika, Sakashita Naomi, Takeya Motohiro, Tsukamoto Sachiko, Ikeda Tsuyoshi
概要 Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.
DOI 10.1021/jf200193r
ISSN 1520-5118
PMID 21446758