イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2011/04
形態種別 原著論文
査読 査読有り
標題 Lucidenic acids-rich extract from antlered form of Ganoderma lucidenhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK.
執筆形態 共著
掲載誌名 Biochemical and biophysical research communications
掲載区分国外
巻・号・頁 408(1),pp.18-24
著者・共著者 Watanabe Kenji, Shuto Tsuyoshi, Sato Miki, Onuki Kouhei, Mizunoe Shota, Suzuki Shingo, Sato Takashi, Koga Tomoaki, Suico Mary Ann, Kai Hirofumi, Ikeda Tsuyoshi
概要 Here, we showed that triterpenes-rich extract of antlered form of G. lucidum (G. lucidum AF) induces TNFα production in monocytic THP-1 cells. Furthermore, the extract also synergized with lipopolysaccharide (LPS) to induce TNFα production in THP-1 cells, suggesting an immunostimulatory role of triterpenes-rich extract of G. lucidum AF. Notably, the extract enhanced LPS-induced phosphorylation of p38 mitogen-activated protein kinase (MAPK), while it suppressed LPS-induced phosphorylation of c-Jun N-terminal kinase (JNK) MAPK. p38 Inhibitor suppressed TNFα production, while JNK inhibitor enhanced TNFα production, implying that synergistic effect of the extract may work by modulating p38 and JNK MAPKs. Thus, our data demonstrate that lucidenic acids-rich extract from G. lucidum AF enhances LPS-induced immune responses in monocytic THP-1 cells possibly via the modulation of p38 and JNK MAPKs activation.
DOI 10.1016/j.bbrc.2011.03.108
ISSN 1090-2104
PMID 21453678