イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2011
形態種別 原著論文
査読 査読有り
標題 Isolation of salsolinol, a tetrahydroisoquinoline alkaloid, from the marine sponge Xestospongia cf. vansoesti as a proteasome inhibitor.
執筆形態 共著
掲載誌名 Chemical & pharmaceutical bulletin
掲載区分国外
巻・号・頁 59(2),pp.287-90
著者・共著者 Nagasawa Yumiko, Ueoka Reiko, Yamanokuchi Rumi, Horiuchi Naoki, Ikeda Tsuyoshi, Rotinsulu Henki, Mangindaan Remy E P, Ukai Kazuyo, Kobayashi Hisayoshi, Namikoshi Michio, Hirota Hiroshi, Yokosawa Hideyoshi, Tsukamoto Sachiko
概要 Salsolinol (1), a tetrahydroisoquinoline alkaloid, was isolated from the marine sponge Xestospongia cf. vansoesti collected in Indonesia as a proteasome inhibitor, along with three salsolinol derivatives, norsalsolinol (2), cis-4-hydroxysalsolinol (3), and trans-4-hydroxysalsolinol (4). Compounds 1 and 2 inhibited the chymotrypsin-like activity of the proteasome with IC(50) values of 50 and 32 µg/ml, respectively, but 3 and 4 showed no inhibitory effect even at 100 µg/ml.
DOI 10.1248/cpb.59.287
ISSN 1347-5223
NAID 130000405530
PMID 21297314