イケダ ツヨシ   Ikeda Tsuyoshi
  池田 剛
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2010/10
形態種別 総説
査読 査読有り
標題 The tomato saponin, esculeoside A.
執筆形態 共著
掲載誌名 Journal of natural products
掲載区分国外
巻・号・頁 73(10),pp.1734-41
著者・共著者 Nohara Toshihiro, Ono Masateru, Ikeda Tsuyoshi, Fujiwara Yukio, El-Aasr Mona
概要 Esculeoside A (2) is a major constituent isolated from Solanum lycopersicum. The content variability of esculeoside A (2) was examined in mini, midi, and Momotaro tomatoes and various processed tomato products. Further, esculeoside A (2) is partly converted to 3β-hydroxy-5α-pregn-16-en-20-one 3-O-β-lycotetraoside (6), a pregnane glycoside, in the overripe fruit. Esculeogenin A (3), the sapogenol of 2, is easily converted into 3β,16β-dihydroxy-5α-pregn-20-one (17). Metabolic studies showed excretion of androstane derivatives in the urine of human volunteer subjects after tomato consumption. Esculeogenin A (3) inhibited the accumulation of cholesterol esters in macrophages through its effects on ACAT. Oral administration of esculeoside A (2) to apoE-deficient mice significantly reduced serum levels of cholesterol, triglycerides, and LDL-cholesterol and ameliorated the severity of atherosclerotic lesions.
DOI 10.1021/np100311t
ISSN 1520-6025
PMID 20853874