タケチ シンジ   Takechi Shinji
  武知 進士
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   崇城大学大学院  工学研究科 応用化学専攻(修士課程)
   職種   教授
言語種別 英語
発行・発表の年月 2015/08
形態種別 原著論文
査読 査読有り
標題 Identification of dihydropyrazine-glutathione adducts.
執筆形態 共著
掲載誌名 J. Toxicol. Sci.
掲載区分国内
巻・号・頁 40(4),pp.495-500
著者・共著者 Takeuchi S, Ito S, Kashige N, Ishida T, Yamaguchi T
概要 Dihydropyrazines (DHPs) are glycation intermediates generated both in vivo and in food. DHPs can lead to the formation of a variety of different radical species, which can lead to DNA damage and enzyme inhibition. In addition, the presence of DHPs can lead to a decrease in cellular glutathione (GSH) levels, and induce the expression of antioxidant genes. In this study, the products resulting from the reaction of DHP with GSH have been analyzed in detail, with some of the products being separated by reversed-phase HPLC. The structures of the isolated DHP-GSH adducts were determined by FAB-MS and NMR analyses. These data suggested that the reaction of DHP with a thiol moiety could be involved in oxidative stress, because an increase in the amount of DHP-GSH adducts would result in a decrease in the cellular GSH levels.
DOI 10.2131/jts.40.495