イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2018/03
形態種別 原著論文
査読 査読有り
標題 Nano-chemotherapy Using Cationic Liposome That Strategically Targets the Cell Membrane Potential of Pancreatic Cancer Cells with Negative Charge
執筆形態 共著
掲載誌名 Bioorganic & Medicinal Chemistry Letters
掲載区分国外
出版社・発行元 Elsevier
巻・号・頁 28(7),pp.1161-1165
著者・共著者 M. Motomura, H. Ichihara, Y. Matsumoto
概要 Negatively charged phosphatidylserine (PS) and sialic acid-containing glycosphingolipids (GM1) were observed to be over represented on the cell membranes of pancreatic cancer cells (BxPC-3) as opposed to normal pancreatic cells. Cationic liposomes (CL) were also found to selectively accumulate into the negatively charged cell membranes of BxPC-3 cells and inhibited their growth but have no effect on the viability of normal pancreatic cells. CL induced apoptosis in BxPC-3 cells via activation of caspase-3, -8, and -9 and mitochondrial events and inhibited tumor enlargement in xenograft mouse models of pancreatic cancer.
DOI 10.1016/j.bmcl.2018.03.013