イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2017/11
形態種別 原著論文
査読 査読有り
標題 Trehalose Liposomes Suppress the Growth of Tumor on Human Lung Carcinoma Bearing Mice by Induction of Apoptosis in Vivo
執筆形態 共著
掲載誌名 Anticancer Research
掲載区分国外
出版社・発行元 The International Institute of Anticancer Research
巻・号・頁 37(11),pp.6133-6139
著者・共著者 H. Ichihara, K. Kuwabara, Y. Matsumoto
概要 We aimed to investigate suppressive effects of DMTreC14 on the growth of tumor on human lung carcinoma bearing mice. The remarkable reduction of volume and weight in subcutaneous tumors on subcutaneous lung carcinoma-bearing mice topically administrated with DMTreC14 were obtained. Apoptotic-positive cells in the subcutaneous tumor slice of subcutaneous lung carcinomabearing mice topically administrated with DMTreC14 were observed using TUNEL staining. Lung weights on the orthotopic graft-bearing mice of lung carcinoma intravenously administrated with DMTreC14 were markedly decreased compared to those of the control group. Remarkable decrease in dimensions of tumor area of lung on the orthotopic graft-bearing mice of lung carcinoma intravenously administrated with DMTreC14 was obtained in histological analysis using the hematoxylin and eosin staining.
DOI 10.21873/anticanres.12062