イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2017/03
形態種別 原著論文
査読 査読有り
標題 Apoptotic and Anti-invasive Effects of Hybrid Liposomes without Drugs against Human Breast Cancer Cells in Vitro
執筆形態 共著
掲載誌名 Journal of Nanomedicine and Biotherapeutic Discovery
掲載区分国外
巻・号・頁 7,pp.1000148-1-1000148-4
著者・共著者 M. Motomura, H. Ichihara, Y. Matsumoto
概要 Hybrid liposomes (HL) composed of 90 mol % L-α-dimyristoylphosphatidylcholine (DMPC) and 10 mol % polyoxyethylene (25) dodecyl ether (C12(EO)25) was examined to study the stimulation of apoptosis and anti-invasive actions against in-vitro cultured human breast cancer (MCF-7) cells. The results obtained from the study reveals that HL suppressed the growth of MCF-7 cells without any drugs. Apoptosis for MCF-7 cells after subjecting them to HL treatment was noticed. To study the non-invasive actions of HL on the drifting of MCF-7 cells, we exercised Wound scratch assay. Non-invasive effects of HL on the migration of MCF-7 cells was obtained on the basis of wound scratch assay. HL suppressed the pseudopodium formation of MCF-7 cells. The study to determine the non-invasive effects of HL against MCF-7 cells were done by matrigel invasion assay which gave positive results due to inhibition of MT1MMP/MMP14 by HL.
DOI 10.4172/2155-983X.1000148