イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2016/11
形態種別 原著論文
査読 査読有り
標題 Therapeutic effects of hybrid liposomes against xenograft mouse model of colorectal cancer in vivo due to long-term accumulation
執筆形態 共著
掲載誌名 Anticancer Research
掲載区分国外
出版社・発行元 The International Institute of Anticancer Research
巻・号・頁 36(11),pp.5875-5882
著者・共著者 H. Ichihara, M. Okumura, Y. Matsumoto
概要 Inhibitory effects of hybrid liposomes (HL) composed of DMPC and C12(EO)25 on the growth of human colorectal cancer (WiDr) cells were obtained along with apoptosis measurement. Selective accumulation of HL, including a fluorescence probe (indocyanine green; (ICG)), was observed for WiDr cells using a fluorescence microscope. Remarkable reduction of tumor volume in xenograft model of mice topically HL-treated without drugs after the subcutaneous inoculation of WiDr cells was verified in vivo. Induction of apoptosis in tumor cells of xenograft mice topically administered with HL was observed in micrographs on the basis of terminal deoxynucleotidyl tranferase-mediated dUTP-biotin nick end labeling (TUNEL) method. Accumulation of HL, including ICG, for long-term into the tumor was obtained in the xenograft model.