イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2015/07
形態種別 原著論文
査読 査読有り
標題 Inhibitory effects of hybrid liposomes on the growth of non-small cell lung carcinoma cells and anti-invasive activity by ceramide generation without any drugs
執筆形態 共著
掲載誌名 Journal of Carcinogenesis & Mutagenesis
掲載区分国外
巻・号・頁 6(4),pp.1000230-1-1000230-5
著者・共著者 H. Ichihara, Y. Komizu, R. Ueoka, Y. Matsumoto
概要 Ceramide generation and invasive inhibition by hybrid liposomes (HL) composed of 90 mol % L-α-dimyristoyl- phosphatidylcholine (DMPC) and 10 mol % polyoxyethylene (23) dodecyl ether (C12(EO)23) were examined for human lung cancer (A549) cells in vitro. Ceramide generation for A549 cells treated with HL was observed through the activation of neutral sphingomyelinase. Sphingomyelin in A549 cells after the treatment with HL were decreased. Anti-invasive effects of HL for A549 cells were obtained through the inhibition of MT1MMP/MMP14. Inhibitory effects of HL on migration of A549 cells was obtained using scratch assay. Inhibitory effects of HL on the growth of A549 cells along with anti-invasive activity by ceramide generation of without any drugs were revealed for the first time.
DOI 10.4172/2157-2518.1000230