イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2014/03
形態種別 原著論文
査読 査読有り
標題 Therapeutic effects of cationic hybrid liposomes on the hepatic metastasis of colon carcinoma along with apoptosis in vivo
執筆形態 共著
掲載誌名 Biological and Pharmaceutical Bulletin
掲載区分国内
巻・号・頁 37(3),pp.498-503
著者・共著者 Ichihara H, Hino M, Ueoka R, Matsumoto Y
概要 Therapeutic effects of cationic hybrid liposomes (HL) on the metastasis of human colon carcinoma (HCT116) cells were examined in vivo. Cationic HL having a hydrodynamic diameter less than 150nm were preserved for one month. Therapeutic effects were obtained in the hepatic metastasis mouse models of HCT116 cells after the intravenous injection of cationic HL. The histological analysis indicated the induction of apoptosis in the liver section of the hepatic metastasis mouse models treated with cationic HL in vivo. Therapeutic effects of cationic HL without any drugs on the hepatic metastasis were revealed for the first time on the basis of histological analyses in vivo.
DOI 10.1248/bpb.b13-00764