イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2012/11
形態種別 原著論文
査読 査読有り
標題 Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo
執筆形態 共著
掲載誌名 European Journal of Medicinal Chemistry
掲載区分国外
巻・号・頁 57,pp.143-148
著者・共著者 Ichihara H, Hino M, Umebayashi M, Matsumoto Y, Ueoka R
概要 Therapeutic effects of hybrid liposomes (HL) composed of l-α-dimyristoylphosphatidylcholine (DMPC) and polyoxyethylene(25) dodecyl ether (C12(EO)25) on the metastasis of human colon carcinoma (HCT116) cells were examined in vivo. Remarkably high therapeutic effects were obtained in the xenograft mouse models of colorectal cancer (CRC) liver metastases after treatment with HL-25 on the basis of relative liver weight and histological analysis of the liver tissue sections of mouse models with HE staining, and TUNEL staining for detection of apoptotic cells. The survival effects of HL-25 were obtained using xenograft mouse models of CRC liver metastases. Furthermore, with regard to pharmacokinetics, the accumulation of fluorescent labeled HL-25 was observed in the liver tissue of xenograft mouse models of CRC liver metastases for 24 h after the intravenous injection of fluorescent labeled HL-25.
DOI 10.1016/j.ejmech.2012.08.040