イチハラ ヒデアキ   Ichihara Hideaki
  市原 英明
   所属   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   教授
言語種別 英語
発行・発表の年月 2008/03
形態種別 原著論文
査読 査読有り
標題 Chemotherapy Using Hybrid Liposomes Along with Induction of Apoptosis
執筆形態 共著
掲載誌名 Anticancer Research
掲載区分国外
巻・号・頁 30(2B),pp.327-338
著者・共著者 Ichihara H, Nagami H, Kiyokawa T, Matsumoto Y, Ueoka R.
概要 The IC50 of hybrid liposomes (HL, DMPC/C12(EO)23) on the growth of human B lymphoma (RAJI) cells was one half of that of DMPC liposomes. Induction of apoptosis by HL in RAJI cells was observed on the basis of flow cytometric analysis, agarose gel electrophoresis and fluorescence microscopy. The therapeutic effects of HL in vivo were examined using SCID mice inoculated with RAJI cells. Markedly prolonged survival of mice was obtained after treatment with HL. No adverse effects were observed in normal rats in toxicity tests carried out with HL. Clinical applications of HL for patients were examined after the approval of the Bioethics Committee. Remarkable reduction of a solid tumor and prolonged survival for one patient with advanced lymphoma were attained after treatment using HL.