スギウラ マサハル   Sugiura Masaharu
  杉浦 正晴
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2018/11
形態種別 原著論文
査読 査読有り
標題 Catalytic Enantioselective Aldol Reactions of Unprotected Carboxylic Acids under Phosphine Oxide Catalysis
執筆形態 共著
掲載誌名 Angewandte Chemie - International Edition
掲載区分国外
巻・号・頁 57,pp.15877-15881
著者・共著者 Shunsuke Kotani, Shunsuke Kotani, Yusaku Yoshiwara, Masamichi Ogasawara, Masaharu Sugiura, Makoto Nakajima
概要 © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim The first catalytic enantioselective aldol reaction of various unprotected carboxylic acids is described. In the presence of a chiral bis(phosphine oxide) as a Lewis base catalyst, carboxylic acids were activated with silicon tetrachloride to form the corresponding bis(trichlorosilyl)enediolates in situ, which subsequently underwent an aldol reaction with an aldehyde or a ketone to produce β-hydroxycarboxylic acids in high enantioselectivities of up to 92 % ee.
DOI 10.1002/anie.201810599
ISSN 14337851
PMID 30298544
PermalinkURL https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85056178838&origin=inward