スギウラ マサハル   Sugiura Masaharu
  杉浦 正晴
   所属   崇城大学  薬学部 薬学科
   崇城大学大学院  薬学研究科 薬学専攻
   職種   教授
言語種別 英語
発行・発表の年月 2014/03
形態種別 原著論文
査読 査読有り
標題 Diastereoselective Synthesis of 1,3-Diamines by a Domino Reaction of Imines, Enamines, and Trichlorosilane.
執筆形態 共著
掲載誌名 Tetrahedron Lett.
掲載区分国外
巻・号・頁 55,pp.1924-1926
著者・共著者 Kashiwagi, T.; Kotani, S.; Nakajima, M.; Sugiura, M.
概要 In this study, we report a new highly diastereoselective domino reaction of imines, enamines, and trichlorosilane. The reaction involves CC bond formation between the imine and enamine followed by the intramolecular reduction of the resulting iminium intermediate by the hydrosilyl group, affording a 1,2-anti-2,3-anti-1,3-diamine in good yield with high diastereoselectivity. Lewis base catalysts such as HMPA increased the chemical yield without decreasing the diastereoselectivity. © 2014 Elsevier Ltd. All rights reserved.
DOI 10.1016/j.tetlet.2014.01.152
ISSN 00404039
PermalinkURL https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84896719518&origin=inward