コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 英語
発行・発表の年月 2008/06
形態種別 原著論文
査読 査読あり
標題 Antitumor and immunostimulatory effects of residual powder from barley-Shochu distillation remnants
執筆形態 共著
掲載誌名 J. Health Sci.
巻・号・頁 54(3),pp.287-293
著者・共著者 Funamoto K, Komizu Y, Ichihara H, Tanoue O, Goto K, Ueoka R
概要 The development of effective utilization methods of Shochu distillation remnants is desirable from the viewpoint of environmental protection and biomass. In this study, we examined inhibitory effects of the powder (barley-powder) obtained from the barley-Shochu distillation remnants on the various tumor cells in vitro and immunostimulation effect in vivo. Remarkable inhibitory effects on the growth of human lung tumor cells along with the induction of apoptosis were obtained for barley-powder in vitro. On the other hand, the barley-powder induced the production of serum Interferon (IFN)-γ for normal rats in vivo, and increased natural killer (NK) activity. Furthermore, the barley-powder showed no acute toxicity in the tail vein administration to normal rats. It was found that the barley-powder had not only an antitumor effect but also an immunostimulation effect for the first time.
DOI http://dx.doi.org/10.1248/jhs.54.287