コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 英語
発行・発表の年月 2013/06
形態種別 原著論文
査読 査読あり
標題 Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells
執筆形態 共著
掲載誌名 Cancer Med.
巻・号・頁 2(3),pp.267-276
著者・共著者 Kitajima H, Komizu Y, Ichihara H, Goto K, Ueoka R
概要 Antitumor effects of hybrid liposomes (HL) composed of DMPC and C12(EO)23 on the metastatic growth of murine osteosarcoma (LM8) cells were investigated in vitro and in vivo. Remarkable inhibitory effects of HL on the growth of LM8 cells were obtained through the induction of apoptotic cell death in vitro. It was also indicated that HL should dramatically suppress the invasion of LM8 cells and the formation of filopodia on the cell surface in vitro. Furthermore, significantly high therapeutic effects were observed in the homograft mouse models of LM8 cells with lung metastasis after the treatment with HL in vivo. In addition, it was found that HL significantly decreased the lung metastasis of LM8 cells in the mouse models through the inhibition of primary tumor invasion. These results suggest that HL could be a novel agent for the chemotherapy of osteosarcoma.
DOI 10.1002/cam4.67