コミズ ユウジ
Komizu Yuuji
古水 雄志 所属 崇城大学 生物生命学部 生物生命学科 崇城大学大学院 工学研究科 応用生命科学専攻(博士前期課程) 崇城大学 生物生命学部 応用生命科学科 崇城大学大学院 工学研究科 応用生命科学専攻(博士後期課程) 職種 准教授 |
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言語種別 | 英語 |
発行・発表の年月 | 2012/07 |
形態種別 | 原著論文 |
査読 | 査読あり |
標題 | Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway |
執筆形態 | 共著 |
掲載誌名 | J. Biosci. Bioeng. |
巻・号・頁 | 114(1),pp.104-109 |
著者・共著者 | Ohgidani M, Komizu Y, Goto K, Ueoka R |
概要 | Shochu distillation remnants (SDR) are by-products in the manufacturing process of the Japanese liquor Shochu and include various useful organic compounds derived from the fermentation of grains. We have obtained valuable powder (PSDR) from freeze-dried SDR by the treatment with ethanol. In this study, we examined the anticancer effects of barley-, rice-, and sweet potato-PSDR against human hepatocellular carcinoma (HCC) in vitro. All PSDR inhibited the growth of both these HCC cells through the induction of apoptosis. Especially, barley-PSDR was the most effective for the growth inhibition and apoptosis induction of HCC cells of all PSDR. Furthermore, barley-PSDR induced the nuclear translocation of apoptosis-inducing factor (AIF) from mitochondria, while it did not significantly affect the activities of caspase-3, -8, and -9. The results suggested that barley-PSDR induced apoptosis against HCC cells via the caspase-independent mitochondrial pathway. |
DOI | http://dx.doi.org/10.1016/j.jbiosc.2012.02.026 |