コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 英語
発行・発表の年月 2011/09
形態種別 原著論文
査読 査読あり
標題 Remarkable inhibitory effects of hybrid liposomes on growth of human colon cancer cells through induction of cell cycle arrest along with apoptosis
執筆形態 共著
掲載誌名 Int. J. Nanomed.
巻・号・頁 2011(6),pp.1913-1920
著者・共著者 Komizu Y, Ueoka H, Goto K, Ueoka R
概要 Hybrid liposomes can be prepared by simply sonicating a mixture of vesicular and micellar molecules in buffer solutions. In this study, we investigated the effects of hybrid liposomes on the growth of human colon cancer cells in vitro. Significant growth inhibition of HCT116 cells was observed in the presence of HL-n. The fifty percent inhibitory concentration (IC50) of HL-n was less than half that of DMPC liposomes. Furthermore, fluorescence microscopic and flow cytometric analyses indicated that the markedly inhibitory effects of HL-n on the growth of HCT116 cells could be attained through the induction of cell cycle arrest at the G0/G1 phase along with apoptotic cell death.
DOI http://dx.doi.org/10.2147/IJN.S24160