コミズ ユウジ   Komizu Yuuji
  古水 雄志
   所属   崇城大学  生物生命学部 生物生命学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士前期課程)
   崇城大学  生物生命学部 応用生命科学科
   崇城大学大学院  工学研究科 応用生命科学専攻(博士後期課程)
   職種   准教授
言語種別 英語
発行・発表の年月 2011/04
形態種別 原著論文
査読 査読あり
標題 Therapeutic effects of Ca2+ on peritoneal dissemination of gastric carcinoma in vivo
執筆形態 共著
掲載誌名 J. Health Sci.
巻・号・頁 57(2),pp.210-214
著者・共著者 Tatsumi K, Ichihara H, Komizu Y, Goto K, Ueoka R
概要 It is well known that oral calcium supplementation has inhibited the gastric carcinogenesis in animals treated with chemical carcinogen and sodium chloride. However, the therapeutic effects of calcium ion (Ca2+) for peritoneal dissemination of gastric carcinoma in vivo remain unknown. Here, we showed that Ca2+ could be effective for inhibiting the peritoneal metastasis of gastric carcinoma MKN-45 cells along with apoptosis in vivo. Significantly prolonged survival was obtained for the peritoneal dissemination mouse models of MKN-45 cells after the intraperitoneal injection (i.p.) of Ca2+. These results suggest that Ca2+ could be a new candidate i.p. drug against peritoneal dissemination of gastric cancer in human.
DOI http://dx.doi.org/10.1248/jhs.57.210