Faculty Information - Murase Hirotaka

Murase Hirotaka

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2026	Papers	RNA-binding fluorogenic probes: G-clamp conjugated with a thiazole orange derivative for screening RNA-binding small molecules, RSC Chemical Biology, 2026, 7, 49-57 (Co-authored)
2.	2025	Papers	Sequence-Selective 2'-O-Acetyl Modification of RNA Mediated by Duplex Formation with a Reactive Oligonucleotide Probe Incorporating 4-Thio-dT, Chemical and Pharmaceutical Bulletin, 2025, 73, 1122-1125 (Co-authored)
3.	2025	Papers	New Nucleoside Derivatives for Hybridization-Assisted Catalysis of Site-Selective Acetylation of 2'-OH of RNA, Chemical and Pharmaceutical Bulletin, 2025, 73, 457-466 (Co-authored)
4.	2025	Papers	Crystallographic analysis of G-clamp–RNA complex assisted by large scale RNA-binding profile, Chemical Communications, 2025, 61, 1120-1123 (Co-authored)
5.	2024	Papers	Site-specific acetyl modification of 2'-OH of RNA by an oligonucleotide acetylating reagent, Chemical Communications, 2024, 60, 13440–13442 (Co-authored)
6.	2024	Papers	Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA, Nucleic Acids Research, 2024, 52, 12141–12157 (Co-authored)
7.	2024	Papers	Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs, Nucleic Acids Research, 2024, 52, 10754-10774 (Co-authored)
8.	2024	Papers	The selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. Coli translation system, Bioorganic & Medicinal Chemistry, 2024, 111, 117868 (Co-authored)
9.	2024	Papers	2'-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants, Bioorganic & Medicinal Chemistry, 2024, 110, 117813 (Co-authored)
10.	2024	Papers	Development of PCR primers enabling the design of flexible sticky ends for efficient concatenation of long DNA fragments, RSC Chemical Biology, 2024, 5, 360-371 (Co-authored)
11.	2024	Papers	Ibuprofen‑derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non‑caspase 3/7‑mediated pathway, Biomedical Reports, 2024, 21, 159 (Co-authored)
12.	2024	Papers	Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries, Communications Chemistry, 2024, 7, 98 (Co-authored)
13.	2024	Papers	Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells, Anticancer Research, 2024, 44, 3793-3798 (Co-authored)
14.	2024	Papers	Manipulating nucleic acids-regulation of gene expression through higher order structure and chemical modification, (Co-authored)
15.	2023	Papers	Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures, Nature Communications, 2023, 14, 2657 (Co-authored)
16.	2023	Papers	Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA, Chemical and Pharmaceutical Bulletin, 2023, 71, 64-69 (Co-authored)
17.	2023	Papers	The Effect of γ Phosphate Modified Deoxynucleotide Substrates on PCR Activity and Fidelity, ChemBioChem, 24, e202200572 (Co-authored)
18.	2022	Papers	Application of the Functionality Transfer Oligodeoxynucleotide for the Site-Selective Modification of RNA with a Divers Molecule, Chemical and Pharmaceutical Bulletin, 2022, 70, 498-504 (Co-authored)
19.	2022	Papers	Development of a selective ligand for G–G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure, Organic & Biomolecular Chemistry, 20, 3375-3381 (Co-authored)
20.	2022	Papers	Drug Discovery Research Toward the Small Molecular Therapeutic Agents for Repeat Expansion Diseases, Nagasaki International University Review (Co-authored)
21.	2021	Papers	Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells, Bioconjugate Chemistry, 2021, 32, 385-393 (Co-authored)
22.	2020	Papers	Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands, Bioorganic & Medicinal Chemistry, 2020, 28, 115730-115730 (Co-authored)
23.	2019	Papers	Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp, Bioorganic & Medicinal Chemistry Letters, 2019, 29, 1320-1324 (Co-authored)
24.	2018	Papers	Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay, Bioorganic & Medicinal Chemistry Letters, 2018, 28, 1832-1835 (Co-authored)
25.	2018	Papers	Synthesis and Properties of 2'-OMe-RNAs Modified with Cross-Linkable 7-Deazaguanosine Derivatives, The Journal of Organic Chemistry 2018, 83, 8851-8862 (Co-authored)