教員情報 - 村瀬　裕貴

ムラセ　ヒロタカ Murase Hirotaka
村瀬　裕貴

所属薬学部薬学科

職種助教

著書・論文歴
1.	2025	論文	Crystallographic analysis of G-clamp–RNA complex assisted by large scale RNA-binding profile, Chemical Communications, 61, 1120-1123 (共著)
2.	2024	論文	Site-specific acetyl modification of 2'-OH of RNA by an oligonucleotide acetylating reagent, Chemical Communications, 60, 13440–13442 (共著)
3.	2024	論文	Development of hydrophobic tag purifying monophosphorylated RNA for chemical synthesis of capped mRNA and enzymatic synthesis of circular mRNA, Nucleic Acids Research, 52, 12141–12157 (共著)
4.	2024	論文	Synthesis of 2'-formamidonucleoside phosphoramidites for suppressing the seed-based off-target effects of siRNAs, Nucleic Acids Research, 52, 10754-10774 (共著)
5.	2024	論文	The selective chemical modification of the 6-amino group of adenosine of the premature termination codon induces readthrough to produce full-length peptide in the reconstituted E. Coli translation system, Bioorganic & Medicinal Chemistry, 111, 117868 (共著)
6.	2024	論文	2'-β-Methylselenyl nucleos(t)ide analogs as reverse transcriptase inhibitors against diverse HIV mutants, Bioorganic & Medicinal Chemistry 110, 117813 (共著)
7.	2024	論文	Development of PCR primers enabling the design of flexible sticky ends for efficient concatenation of long DNA fragments, RSC Chemical Biology, 5, 360-371 (共著)
8.	2024	論文	Ibuprofen‑derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non‑caspase 3/7‑mediated pathway, Biomedical Reports, 21, 159 (共著)
9.	2024	論文	Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries, Communications Chemistry, 7, 98 (共著)
10.	2024	論文	Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells, Anticancer Research, 44, 3793-3798 (共著)
11.	2024	論文	核酸を操る高次構造と化学修飾による発現制御, Drug Delivery System, 39, 53-62 (共著)
12.	2023	論文	Cap analogs with a hydrophobic photocleavable tag enable facile purification of fully capped mRNA with various cap structures, Nature Communications, 14, 2657 (共著)
13.	2023	論文	Site-Specific Tritium Labeling at the Predefined Internal Position of the Chemically-Modified RNA, Chemical and Pharmaceutical Bulletin, 71, 64-69 (共著)
14.	2023	論文	The Effect of γ Phosphate Modified Deoxynucleotide Substrates on PCR Activity and Fidelity, ChemBioChem, 24, e202200572 (共著)
15.	2022	論文	Application of the Functionality Transfer Oligodeoxynucleotide for the Site-Selective Modification of RNA with a Divers Molecule, Chemical and Pharmaceutical Bulletin 70, 498-504 (共著)
16.	2022	論文	Development of a selective ligand for G–G mismatches of CGG repeat RNA inducing the RNA structural conversion from the G-quadruplex into a hairpin-like structure, Organic & Biomolecular Chemistry, 20, 3375-3381 (共著)
17.	2022	論文	リピート病の治療薬開発を目指した低分子創薬研究, 長崎国際大学論叢, 22, 177-185 (共著)
18.	2021	論文	Artificial Host Molecules to Covalently Capture 8-Nitro-cGMP in Neutral Aqueous Solutions and in Cells, Bioconjugate Chemistry, 32, 385-393 (共著)
19.	2020	論文	Protection of all cleavable sites of DNA with the multiple CGCG or continuous CGG sites from the restriction enzyme, indicative of simultaneous binding of small ligands, Bioorganic & Medicinal Chemistry 28, 115730-115730 (共著)
20.	2020	論文	核酸の高次構造・特殊配列に結合する低分子化合物 ‒基盤分子の開発/評価法の構築‒, 日本核酸化学会誌, 4, 15-21 (単著)
21.	2019	論文	Development of the binding molecules for the RNA higher-order structures based on the guanine-recognition by the G-clamp, Bioorganic & Medicinal Chemistry Letters 29, 1320-1324 (共著)
22.	2018	論文	Evaluation of simultaneous binding of Chromomycin A3 to the multiple sites of DNA by the new restriction enzyme assay, Bioorganic & Medicinal Chemistry Letters, 28, 1832-1835 (共著)
23.	2018	論文	Synthesis and Properties of 2'-OMe-RNAs Modified with Cross-Linkable 7-Deazaguanosine Derivatives, The Journal of Organic Chemistry 83, 8851-8862 (共著)