教員情報 - 高橋　大輔

タカハシ　ダイスケ Takahashi Daisuke
高橋　大輔

所属薬学部薬学科

職種准教授

著書・論文歴
1.	2008/06	論文	Heterogeneous packing in the folding/unfolding intermediate state of bitter gourd trypsin inhibitor Bioscience Biotechnology and Biochemistry 72 (6),1498-1505頁 (共著)
2.	2008/06	論文	Protein-protein interaction on lysozyme crystallization revealed by rotational diffusion analysis Biophysical Journal 94 (11),4484-4492頁 (共著)
3.	2009/07	論文	Steady-State and Time-Resolved Fluorescence Spectroscopic Studies on Interaction of the N-terminal Region with the Hairpin Loop of the Phytocystain Scb Journal of Fluorescence 19 (4),631-639頁 (共著)
4.	2010/09	論文	Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity BIOCHIMIE 92 (9),1236-1241頁 (共著)
5.	2010/12	論文	Morphology and Structural Properties of pH-Responsive Amphiphilic Peptides Journal of Nanoscience and Nanotechnology 10 (12),7981-7987頁 (共著)
6.	2011/10	論文	Rotational Diffusion Analysis of Polyethylene Glycol Induced Protein Interactions JOURNAL OF PHYSICAL CHEMISTRY B 115 (41),11786-11792頁 (共著)
7.	2012/02	論文	Characterization and inhibition of norovirus proteases of genogroups I and II using a fluorescence resonance energy transfer assay Virology 423 (2),125-133頁 (共著)
8.	2012/04	論文	Backbone and side-chain ¹H, ¹⁵N, and ¹³C resonance assignments of Norwalk virus protease. Biomolecular NMR assignments 6 (1),19-21頁 (共著)
9.	2013/01	論文	An initial event in the insect innate immune response: structural and biological studies of interactions between β-1,3-glucan and the N-terminal domain of β-1,3-glucan recognition protein. Biochemistry 52 (1),161-170頁 (共著)
10.	2013/03	論文	Structural and dynamics characterization of norovirus protease Protein Science 22 (3),347-357頁 (共著)
11.	2013/12	論文	Structural and inhibitor studies of norovirus 3C-like proteases Virus Research 178 (2),437-444頁 (共著)
12.	2014/10	論文	Self-association of an insect β-1,3-glucan recognition protein upon binding laminarin stimulates prophenoloxidase activation as an innate immune response. The Journal of biological chemistry 289 (41),28399-28410頁 (共著)
13.	2015/11	論文	Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects. Proceedings of the National Academy of Sciences of the United States of America 112 (45),13856-13861頁 (共著)
14.	2016/08	論文	Characterization and regulation of expression of an antifungal peptide from hemolymph of an insect, Manduca sexta Developmental and Comparative Immunology 61,258-268頁 (共著)
15.	2016/10	論文	H-1, N-15, and C-13 resonance assignments of Staphylococcus aureus extracellular adherence protein domain 4 BIOMOLECULAR NMR ASSIGNMENTS 10 (2),301-305頁 (共著)
16.	2016/12	論文	Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation. Biochemistry and Biophysics Reports 8,352-359頁 (共著)
17.	2017/03	論文	Dioleoyl-phosphatidic acid selectively binds to a-synuclein and strongly induces its aggregation FEBS Letters 591 (5),784-791頁 (共著)
18.	2018	論文	Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines. Journal of Cellular Biochemistry (共著)
19.	2018	論文	Expression and purification of human diacylglycerol kinase α from baculovirus-infected insect cells for structural studies. PeerJ 6,e5449 (共著)
20.	2018/01	論文	Where do substrates of diacylglycerol kinases come from? Diacylglycerol kinases utilize diacylglycerol species supplied from phosphatidylinositol turnover-independent pathways Advances in Biological Regulation 67,101-108頁 (共著)
21.	2018/03	論文	Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain. Biochemical and Biophysical Research Communications 497 (4),1031-1037頁 (共著)
22.	2018/09	論文	Diacylglycerol kinase β induces filopodium formation via its C1, catalytic and carboxy-terminal domains and interacts with the Rac1-GTPase-activating protein, β2-chimaerin. Biochemical and Biophysical Research Communications 504 (1),54-60頁 (共著)
23.	2019/03	論文	Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ ACS Omega 4 (3),5540-5546頁 (共著)
24.	2019/04	論文	Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains. Protein Science 28 (4),694-706頁 (共著)
25.	2019/07	論文	Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells. Biochimica et BiophysicaActa. Molecular and cell biology of lipids 1864 (7),1031-1038頁 (共著)
26.	2019/09	論文	Microarray analysis of gene expression in the diacylglycerol kinase η knockout mouse brain. Biochemistry and Biophysics Reports 19,100660-100660頁 (共著)
27.	2019/11	論文	Characterization of α-synuclein N-terminal domain as a novel cellular phosphatidic acid sensor. The FEBS journal in press (11),2212-2234頁 (共著)
28.	2020/05	論文	Palmitic acid- and/or palmitoleic acid-containing phosphatidic acids are generated by diacylglycerol kinase α in starved Jurkat T cells. Biochemical and Biophysical Research Communications 525 (4),1054-1060頁 (共著)
29.	2020/07	論文	Peptides based on the reactive center loop of Manduca sexta serpin-3 block its protease inhibitory function. Scientific Reports 10 (1),11497-11497頁 (共著)
30.	2021	論文	Optimization of SARS-CoV-2 Spike Protein Expression in the Silkworm and Induction of Efficient Protective Immunity by Inoculation With Alum Adjuvants. Frontiers in Immunology 12,803647-803647頁 (共著)
31.	2021/06	論文	Membrane morphology determines diacylglycerol kinase α substrate acyl chain specificity. FASEB journal 35 (6),e21602 (共著)
32.	2021/07	論文	Diacylglycerol kinase η colocalizes and interacts with apoptosis signal-regulating kinase 3 in response to osmotic shock. Biochemistry and Biophysics Reports 26,101006-101006頁 (共著)
33.	2021/07	論文	Production of scFv, Fab, and IgG of CR3022 Antibodies Against SARS-CoV-2 Using Silkworm-Baculovirus Expression System. Molecular Biotechnology 63 (12),1223-1234頁 (共著)
34.	2021/10	論文	The Roles of Diacylglycerol Kinase α in Cancer Cell Proliferation and Apoptosis. Cancers 13 (20) (共著)
35.	2022/01	論文	Improvement of the affinity of an anti-rat P2X4 receptor antibody by introducing electrostatic interactions. Scientific Reports 12 (1),131-131頁 (共著)
36.	2022/02	論文	Effect of Alkynyl Group on Reactivity in Photoaffinity Labeling with 2-Thienyl-Substituted α-Ketoamide. Chemistry 28 (11),e202103925 (共著)
37.	2022/03	論文	Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis. Biochemical and Biophysical Research Communications 596,22-28頁 (共著)
38.	2022/03	論文	α-Amino acid and peptide synthesis using catalytic cross-dehydrogenative coupling. Nature Synthesis (共著)
39.	2022/07	論文	Ca²⁺ ‐induced structural changes and intramolecular interactions in N‐terminal region of diacylglycerol kinase alpha Protein Science 31 (7) (共著)
40.	2022/10	論文	Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease. Journal of Medicinal Chemistry 65 (20),13852-13865頁 (共著)
41.	2023/02/21	論文	Effects of Ca2+ ions on the horseshoe crab coagulation cascade triggered by lipopolysaccharide. Journal of biochemistry 174 (1),47-58頁 (共著)
42.	2023/05/19	論文	Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life. Science Advances 9 (20),eadg2379 (共著)