Faculty Information - Esaki Kayoko

Esaki Kayoko

Department / Course FACULTY OF BIOTECHNOOLOGY AND LIFE SCIENCE Department of Biotechnology and Life Sciences

Job

Book and thesis
1.	2024/04	Papers	SPTLC2 variants are associated with early-onset ALS and FTD due to aberrant sphingolipid synthesis. Ann Clin Transl Neurol . 11 (4),pp.946-957 (Co-authored)
2.	2023/10	Papers	Impairment of serine transport across the blood–brain barrier by deletion of Slc38a5 causes developmental delay and motor dysfunction. Proc Natl Acad Sci U S A 120 (42),pp.e2302780120 (Co-authored)
3.	2021/09	Papers	Hepatocyte-Specific Phgdh-Deficient Mice Culminate in Mild Obesity, Insulin Resistance, and Enhanced Vulnerability to Protein Starvation. Nutrients. 13 (10),pp.3468 (Co-authored)
4.	2021/01	Papers	Lipid Pathology of the Corpus Callosum in Schizophrenia and the Potential Role of Abnormal Gene Regulatory Networks with Reduced Microglial Marker Expression. Cereb. Cortex. 31 (1),pp.448-462 (Co-authored)
5.	2020/04	Papers	Evidence for Altered Metabolism of Sphingosine-1-Phosphate in the Corpus Callosum of Patients with Schizophrenia. Schizophr. Bull. 46 (5),pp.1172-1181 (Co-authored)
6.	2019/06	Papers	Investigation of betaine as a novel psychotherapeutic for schizophrenia. EBioMedicine. 45,pp.432-446 (Co-authored)
7.	2018/09	Papers	The ASCT1 (Slc1a4) Transporter is a Physiologic Regulator of Brain D-Serine and Neurodevelopment. Proc. Natl. Acad. Sci. USA. 115 (38),pp.9628-9633 (Co-authored)
8.	2016/03	Papers	Adaptive response to L-serine deficiency is mediated by p38 MAPK activation via 1-deoxysphinganine in normal fibroblasts. FEBS Open Bio. 6 (4),pp.303-316 (Co-authored)
9.	2015/04	Papers	L-Serine deficiency elicits intracellular accumulation of cytotoxic deoxy-sphingolipids and lipid body formation. J. Biol. Chem. 290 (23),pp.14595-14609 (Co-authored)
10.	2014/10	Papers	Exon resequencing of H3K9 methyltransferase complex genes, EHMT1, EHMT2 and WIZ, in Japanese autism subjects. Molecular Autism 5 (1),pp.49 (Co-authored)
11.	2013/04	Papers	Increased tyrosine in the brain and serum of mice by orally administering dipeptide SY. Biosci. Biotech. Biochem. 77 (4),pp.847-849 (Co-authored)
12.	2013/02	Papers	L-serine deficiency caused by genetic Phgdh deletion leads to robust induction of 4E-BP1 and subsequent repression of translation initiation in the developing central nervous system. FEBS J. 280 (6),pp.1502-1517 (Co-authored)
13.	2013/02	Papers	Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia. Neuropsychopharmacology 38 (8),pp.1409-1425 (Co-authored)
14.	2011/11	Papers	Soy peptide ingestion increases neuroactive amino acids in the brain of wild-type and genetically engineered serine-deficient mice. J. Nutr. Food Sci. 1 (4),pp.109 (Co-authored)
15.	2010/12	Papers	Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain. J. Biol. Chem. 285 (53),pp.41380-41390 (Co-authored)