教員情報 - 宮内　優

ミヤウチ　ユウ Miyauchi Yuu
宮内　優

所属薬学部薬学科

職種講師

著書・論文歴
1.	2022	論文	Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of toxicological sciences 47 (9),381-387 (共著)
2.	2022	論文	Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in pharmacology 13,832931 (共著)
3.	2022	論文	[Protein-Protein Interactions as Underlying Regulatory Mechanisms of Drug-metabolizing Enzyme Function]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 142 (11),1169-1175 (単著)
4.	2021/11	論文	Adenine-related compounds modulate UDP-glucuronosyltransferase (UGT) activity in mouse liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems 51 (11),1247-1254 (共著)
5.	2021/04	論文	LAPTM4a is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins. Biochem. Biophys. Res. Commun. 556,9-15頁 (共著)
6.	2021	論文	The in vitro inhibitory effects of nobiletin, a polymethoxyflavonoid from Citrus depressa, on the hepatic enzyme activity of dams maternally exposed to low-dose 2,3,7,8-tetrachlorodibenzo-p-dioxin 福岡医学雑誌 112 (2),136-147頁 (共著)
7.	2021/09	論文	DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Scientific reports 11 (1),18532 (共著)
8.	2021	論文	Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products. The Journal of toxicological sciences 46 (11),509-514 (共著)
9.	2021	論文	Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological & pharmaceutical bulletin 44 (11),1635-1644 (共著)
10.	2020	論文	The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. J. Toxicol. Sci. 45 (7),401-409頁 (共著)
11.	2020/10	論文	The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35 (5),466-474 (共著)
12.	2020/04	論文	Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells. Bioscience Reports 40 (4) (共著)
13.	2020/04	論文	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT. Biochemical and Biophysical Research Communications 525 (2),348-353 (共著)
14.	2020/03	論文	UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. British Journal of Pharmacology 177 (5),1077-1089 (共著)
15.	2019/10	論文	Advantage of a co-expression system for estimating physiological effects of functional interaction between cytochrome P450 3A4 and uridine 5’-diphospho-glucuronosyltransferase 2B7. BPB Reports 2 (5),61-6 (共著)
16.	2019/05	論文	Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants. Molecular Pharmacology 95 (5),551-562 (共著)
17.	2017/12	論文	Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Cellular Signalling 40,200-209 (共著)
18.	2017/05	論文	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation. The Journal of Pharmacology and Experimental Therapeutics 361 (2),199-208 (共著)
19.	2016	論文	Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation. Frontiers in Pharmacology 7,427 (共著)
20.	2015/10	論文	Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region. Molecular pharmacology 88 (4),800-12 (共著)
21.	2014/02	論文	Alteration of the function of the UDP-glucuronosyltransferase 1A subfamily by cytochrome P450 3A4: different susceptibility for UGT isoforms and UGT1A1/7 variants. Drug Metabolism and Disposition 42 (2),229-38 (共著)
22.	2012	論文	Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols. Biological & pharmaceutical bulletin 35 (10),1811-7 (共著)