Faculty Information - Miyauchi Yuu

Miyauchi Yuu

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2022	Papers	Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells. The Journal of toxicological sciences 47 (9),pp.381-387 (Co-authored)
2.	2022	Papers	Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4. Frontiers in pharmacology 13,pp.832931 (Co-authored)
3.	2021/04	Papers	LAPTM4a is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins. Biochem. Biophys. Res. Commun. 556,pp.9-15 (Co-authored)
4.	2021/09	Papers	DAPL1 is a novel regulator of testosterone production in Leydig cells of mouse testis. Scientific reports 11 (1),pp.18532 (Co-authored)
5.	2021	Papers	Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products. The Journal of toxicological sciences 46 (11),pp.509-514 (Co-authored)
6.	2021	Papers	Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological & pharmaceutical bulletin 44 (11),pp.1635-1644 (Co-authored)
7.	2020	Papers	The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. J. Toxicol. Sci. 45 (7),pp.401-409 (Co-authored)
8.	2020/10	Papers	The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35 (5),pp.466-474 (Co-authored)
9.	2020/04	Papers	Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells. Bioscience Reports 40 (4) (Co-authored)
10.	2020/04	Papers	Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT. Biochemical and Biophysical Research Communications 525 (2),pp.348-353 (Co-authored)
11.	2020/03	Papers	UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression. British Journal of Pharmacology 177 (5),pp.1077-1089 (Co-authored)
12.	2019/10	Papers	Advantage of a co-expression system for estimating physiological effects of functional interaction between cytochrome P450 3A4 and uridine 5’-diphospho-glucuronosyltransferase 2B7. BPB Reports 2 (5),pp.61-6 (Co-authored)
13.	2019/05	Papers	Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants. Molecular Pharmacology 95 (5),pp.551-562 (Co-authored)
14.	2017/12	Papers	Glucose elicits serine/threonine kinase VRK1 to phosphorylate nuclear pregnane X receptor as a novel hepatic gluconeogenic signal. Cellular Signalling 40,pp.200-209 (Co-authored)
15.	2017/05	Papers	Comprehensive Characterization of Mouse UDP-Glucuronosyltransferase (Ugt) Belonging to the Ugt2b Subfamily: Identification of Ugt2b36 as the Predominant Isoform Involved in Morphine Glucuronidation. The Journal of Pharmacology and Experimental Therapeutics 361 (2),pp.199-208 (Co-authored)
16.	2016	Papers	Introduction of an N-Glycosylation Site into UDP-Glucuronosyltransferase 2B3 Alters Its Sensitivity to Cytochrome P450 3A1-Dependent Modulation. Frontiers in Pharmacology 7,pp.427 (Co-authored)
17.	2015/10	Papers	Suppression of Cytochrome P450 3A4 Function by UDP-Glucuronosyltransferase 2B7 through a Protein-Protein Interaction: Cooperative Roles of the Cytosolic Carboxyl-Terminal Domain and the Luminal Anchoring Region. Molecular pharmacology 88 (4),pp.800-12 (Co-authored)
18.	2012	Papers	Inhibition of morphine glucuronidation in the liver microsomes of rats and humans by monoterpenoid alcohols. Biological & pharmaceutical bulletin 35 (10),pp.1811-7 (Co-authored)