教員情報 - 劉　暁輝

リュウ　ギョウキ LIU Xiaohui
劉　暁輝

所属生物生命学部生物生命学科

職種准教授

著書・論文歴
1.	2026/06/01	論文	Bisphenol BPAF and BPC are agonists for estrogen receptor ERα but antagonists for N-terminal domain-lacking ERα PLoS One 21 (6),e0350499 (共著)
2.	2025/12/27	論文	Evolution of Sitophilus zeamais (Coleoptera: Curculionidae) in artificial rearing and field conditions. The Journal of Basic and Applied Zoology 86 (116) (共著)
3.	2024/10/21	論文	The N-terminal activation function AF-1 domain of ERα interacts directly with the C-terminal AF-2-holding ligand-binding domain to recruit the coactivator proteins. PLOS ONE 19 (10),e0312276 (共著)
4.	2022/02	論文	内分泌撹乱物質・ビスフェノールの核内受容体を介したシグナル毒性の分子メカニズム. BIO九州 (233),5-10頁 (単著)
5.	2021/11	論文	Direct evidence of edge-to-face CH/π interaction for PAR-1 thrombin receptor activation Bioorganic & Medicinal Chemistry 51,116498 (共著)
6.	2021/04	論文	ERα-agonist and ERβ-antagonist bifunctional next-generation bisphenols with no halogens: BPAP, BPB, and BPZ. Toxicology Letters 345,24-33頁 (共著)
7.	2021/02	論文	Bisphenol-C is the strongest bifunctional ERα-agonist and ERβ-antagonist due to magnified halogen bonding. PLOS ONE 16 (2),e0246583 (共著)
8.	2020/02	論文	Evaluation of the influence of halogenation on the binding of bisphenol A to the estrogen-related receptor γ. Chemical Research in Toxicology 33 (4),889-902頁 (共著)
9.	2019/12	論文	Bisphenol AF: Halogen bonding is a major driving force for the dual ERα-agonist and ERβ-antagonist activities. Bioorganic & Medicinal Chemistry 28 (3),115274 (共著)
10.	2019/07	論文	Discovery of novel oestrogen receptor α agonists and antagonists by screening a revisited privileged structure moiety for nuclear receptors. Scientific reports 9 (1),9954 (共著)
11.	2019/06	その他	内分泌撹乱物質から薬ができるかもしれない　ー新規な創薬シード期待される三環系ビスフェノールー. Endocrine Disrupter News Letters （日本内分泌撹乱化学物質学会） 22 (1),2-2頁 (共著)
12.	2019/06	論文	Receptor-binding affinities of bisphenol A and its next-generation analogs for human nuclear receptors. Toxicology and applied pharmacology 377,114610 (共著)
13.	2019/03	その他	Evaluation of the binding ability of an orphan nuclear receptor nurr1 to synthetic peptides. Peptide Science 2018 2018,133 (共著)
14.	2018/03	その他	Homodimer function of human nuclear receptor ERRγ evidenced using α-helix peptides in the dimer interface. Peptide Science 2017,190-191頁 (共著)
15.	2018/03	その他	Mutual co-work between nuclear receptor ERα and ERRα requires their homodimerization. Peptide Science 2017,198-199頁 (共著)
16.	2018/03	その他	Phe271^5.39 of thrombin receptor PAR-1 is a specific target of Phe-2-phenyl group of its tethered ligand. Peptide Science 2017,94-95頁 (共著)
17.	2017/10	論文	Design and synthesis of benzoacridines as estrogenic and anti-estrogenic agents. Bioorganic & medicinal chemistry 25 (20),5216-5237頁 (共著)
18.	2017/08	論文	α-Helix-peptides composing the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization. — Bisphenol A receptor ERRγ physiologically functions as homodimer. Biomedical Advances,ep-20178-10 (共著)
19.	2017/06	論文	乳がん細胞における内分泌撹乱物質ビスフェノールのエストロゲン受容体応答．細胞,（ニュー・サイエンス社）特集「がん治療抵抗性のメカニズム解明に向けた新しいアプローチ」 49 (7),47-51頁 (共著)
20.	2017/03	その他	Docking simulation to elucidated the labeled cysteine residue of the nociception receptor ORL1 using a Cys(Npys)-containing peptide ligand. Peptide Science 2016,87-88頁 (共著)
21.	2016/11	論文	Specific affinity-labeling of the nociceptin ORL1 receptor using a thiol-activated Cys(Npys)-containing peptide ligand. Biopolymers: Peptide Science 106 (4),460-469頁 (共著)
22.	2016/11	論文	α-Helix-peptides comprising the human nuclear receptor ERRγ competitively provoke inhibition of functional homomeric dimerization. Biopolymers: Peptide Science 106 (4),547-554頁 (共著)
23.	2016/06	論文	内分泌撹乱物質ビスフェノールの乳がん細胞におけるエストロゲン受容体応答．細胞,（ニュー・サイエンス社）特集「乳癌研究：最近のトピックス」 48 (7),47-45頁 (共著)
24.	2016/03	その他	Comparative analysis of the ligand binding domain secondary structures of human nuclear receptors. Peptide Science 2015,337-338頁 (共著)
25.	2016/03	その他	Comprehensive structural analysis of the nociception ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods. Peptide Science 2015,149-150頁 (共著)
26.	2016/03	その他	Do the estrogen receptors function as a homodimer? Experimental validation of homodimerization by inhibitory peptides. Peptide Science 2015,335-336頁 (共著)
27.	2016/03	その他	Expression analysis of neuropeptide pdf mRNA in the hypoactive and hyperactive fruit flies Drosophila melanogaster. Peptide Science 2015,317-318頁 (共著)
28.	2016/03	その他	Functional role of the Phe-Phe stacking microswitch in the ORL1 nociceptin receptor activation. Peptide Science 2015,147-148頁 (共著)
29.	2016/03	その他	ORL1 nociceptin receptor response of opioid peptides derived from proenkephalin precursor protein. Peptide Science 2015,181-182頁 (共著)
30.	2016/03	その他	Protein constitutive peptide fragments to inhibit protein-protein interaction: Inhibitory peptides as molecular probe for clarification of human nuclear receptor activation mechanism. Peptide Science 2015,319-320頁 (共著)
31.	2016/03	その他	SCN circadian rhythm signal transduction neuropeptides evoke hypoactive phenotype differently in male and female mice. Peptide Science 2015,53-54頁 (共著)
32.	2015/09	論文	乳がん細胞におけるビスフェノールのエストロゲン様活性. BIO Clinica, (北隆館) 特集「女性がん医療の最前線」 30 (10),90-95頁 (共著)
33.	2015/03	その他	A novel method to identify and quantify the coactivator proteins that couple with human nuclear receptor: The use of interacting interface α-helix peptide for quantitative inhibition. Peptide Science 2014,349-350頁 (共著)
34.	2015/03	その他	Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression. Peptide Science 2014,41-42頁 (共著)
35.	2015/03	その他	GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation. Peptide Science 2014,203-204頁 (共著)
36.	2015/03	その他	Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors. Peptide Science 2014,347-348頁 (共著)
37.	2015/03	その他	The molecular switching of ORL1 nociceptin receptor in activation/ inactivation. Peptide Science 2014,201-202頁 (共著)
38.	2014/06	論文	A characteristic back support structure in the bisphenol A-binding pocket in the human nuclear receptor ERRγ. PloS one 9 (6),e101252 (共著)
39.	2014/03	その他	Bisphenol A- induced epigenetic mutations in circadian pacemaker neuropeptide mRNAs of hyperactive Drosophila fruit flies. Peptide Science 2013,457-458頁 (共著)
40.	2014/03	その他	Constitutive α-helix-peptides required for functional dimerization of estrogen-related receptor γ (ERRγ). Peptide Science 2013,429-430頁 (共著)
41.	2014/03	その他	Expression and mutation analyses of brain neuropeptide genes of endocrine-disrupting bisphenol A-exposed hypoactive mouse. Peptide Science 2013,453-454頁 (共著)
42.	2014/03	その他	Influence analysis of the circadian evening pacemaker neuropeptide hugγ gene in the bisphenol A-exposed fruit fly Drosophila brain. Peptide Science 2013,455-456頁 (共著)
43.	2014/03	その他	Three-dimensional docking modeling to human nuclear receptors for exploration of bisphenol-A targeting receptors. Peptide Science 2013,459-460頁 (共著)
44.	2013/03	その他	Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing. Peptide Science 2012,401-402頁 (共著)
45.	2013/03	その他	The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure. Peptide Science 2012,75-76頁 (共著)
46.	2013/01	論文	ビスフェノールの核内受容体応答の分子メカニズム. Endocrine Disrupter News Letters （日本内分泌撹乱化学物質学会） 15 (4),5 (共著)
47.	2012/04	論文	Fine spatial assembly for construction of the phenol-binding pocket to capture bisphenol A in the human nuclear receptor estrogen-related receptor γ. Journal of biochemistry 151 (4),403-415頁 (共著)
48.	2010/09	論文	Bisphenol AF is a full agonist for the estrogen receptor ERalpha but a highly specific antagonist for ERbeta. Environmental health perspectives 118 (9),1267-1272頁 (共著)
49.	2010/08	論文	Distinction of the binding modes for human nuclear receptor ERRgamma between bisphenol A and 4-hydroxytamoxifen. Journal of biochemistry 148 (2),247-254頁 (共著)
50.	2010/03	その他	Functional role of the C-terminal helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ). Peptide Science 2009,435-436頁 (共著)
51.	2009/07	論文	Placenta expressing the greatest quantity of bisphenol A receptor ERR{gamma} among the human reproductive tissues: Predominant expression of type-1 ERRgamma isoform. Journal of biochemistry 146 (1),113-122頁 (共著)
52.	2009/03	その他	Bisphenol A-specific nuclear receptor ERRγ: Structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain. Peptide Science 2008,517-518頁 (共著)
53.	2009/03	その他	Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ). Peptide Science 2008,521-522頁 (共著)
54.	2008/08	論文	ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner. Biochemical and biophysical research communications 373 (3),408-413頁 (共著)
55.	2008/03	その他	The conformation change-sensing antibodies for retinoid-related orphan receptor family. Peptide Science 2007,491-492頁 (共著)
56.	2008/01	論文	Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma. Environmental health perspectives 116 (1),32-38頁 (共著)
57.	2007/12	論文	Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor gamma. Chief and corroborative hydrogen bonds of the bisphenol A phenol-hydroxyl group with Arg316 and Glu275 residues. The FEBS journal 274 (24),6340-6351頁 (共著)
58.	2007/10	論文	Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. Journal of biochemistry 142 (4),517-524頁 (共著)
59.	2007/03	その他	Conformation change of α-helix peptide for sensing of deactivation of nuclear receptor: Immunoassay using polyclonal antibody specific for the C-terminal α-helix 12 of estrogen-related receptor γ (ERRγ). Peptide Science 2006,176 (共著)
60.	2006/12	論文	Endocrine disruptor bisphenol A strongly binds to human estrogen-related receptor gamma (ERRgamma) with high constitutive activity. Toxicology letters 167 (2),95-105頁 (共著)
61.	2005/03	その他	Structural characteristics of Drosophila estrogen-related receptor ligand binding domain to capture the peptide and non-peptide ligands. Peptide Science 2004,303-304頁 (共著)
62.	2004/04/26	論文	Molecular cloning and circadian expression profile of insect neuropeptide PDF in black blowfly, Phormia regina. Letter in Peptide Science 10,419-430頁 (共著)