教員情報 - 西　弘二

ニシ　コウジ Nishi Kouji
西　弘二

所属薬学部薬学科

職種教授

著書・論文歴
1.	2023	論文	Structural Basis of the Change in the Interaction Between Mycophenolic Acid and Subdomain IIA of Human Serum Albumin During Renal Failure. J Med Chem 66 (1),951-961頁 (共著)
2.	2022	論文	Study of the inclusion complexes formed between 4-phenylbutyrate and α-, β- and γ-cyclodextrin in solution and evaluation on their taste-masking properties. J Pharm Pharmacol. (共著)
3.	2022/08	論文	Chlorine Atoms of an Aripiprazole Molecule Control the Geometry and Motion of Aripiprazole and Deschloro-aripiprazole in Subdomain IIIA of Human Serum Albumin. ACS Omega 7 (34),29944-29951頁 (共著)
4.	2022	論文	Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts. Oncol Rep. 48 (4),178 (共著)
5.	2022	論文	Effect of Fatty Acids and Uremic Toxins on the Binding of Nateglinide, an Insulin Secretagogue, to Site II on Human Serum Albumin. Biol Pharm Bull 45 (6),803-805頁 (共著)
6.	2022/03	論文	The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism. Anticancer Res. 42 (3),1333-1338頁 (共著)
7.	2022/03	論文	In Vitro and In Vivo Assessment of Atemoya Fruit (Annona atemoya) for Food-Drug Interactions. Eur J Drug Metab Pharmacokinet. 47 (2),177-185頁 (共著)
8.	2022/01	論文	Effects of Myristate on the Induced Circular Dichroism Spectra of Aripiprazole Bound to Human Serum Albumin: A Structural-Chemical Investigation. ACS Omega. 7 (5),4413-4419頁 (共著)
9.	2022/01	論文	An in-vitro comparative study of the binding of caspofungin and micafungin to plasma proteins. J Pharm Pharmacol. 74 (5),88-93頁 (共著)
10.	2021/11	論文	The Binding of Aripiprazole to Plasma Proteins in Chronic Renal Failure Patients. Toxins 13 (18),1813 (共著)
11.	2021	論文	Effects of Uremic Toxins on the Binding of Aripiprazole to Human Serum Albumin Biol Pharm Bull. (共著)
12.	2021	論文	Possible Role of Electrolytes on the Formation of Precipitates during the Infusion of Nafamostat Mesilate in Hemodialysis. Biol Pharm Bull. (共著)
13.	2021	論文	Interaction of Benzbromarone with Subdomains IIIA and IB/IIA on Human Serum Albumin as the Primary and Secondary Binding Regions. Mol Pharm (共著)
14.	2021	論文	Synthesis and In Vitro Assessment of pH-Sensitive Human Serum Albumin Conjugates of Pirarubicin. Pharmaceuticals (共著)
15.	2020	論文	Characterization of Bovine Lactoferrin Nanoparticle Prepared by Desolvation Technique. Chem Pharm Bull (共著)
16.	2020	論文	Characterization of the Interaction of Daptomycin With Site II on Human Serum Albumin. J Pharm Sci. (共著)
17.	2020	論文	Effects of Oxidation of Human Serum Albumin on the Binding of Aripiprazole. Biol Pharm Bull. (共著)
18.	2020/05	論文	Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 11 (18),2478 (共著)
19.	2020	論文	Serum Albumin, Lipid and Drug Binding Subcell Biochem 94,383-397頁 (共著)
20.	2019/12	論文	Processing grapefruit juice with γ-cyclodextrin attenuates its inhibitory effect on cytochrome P450 3A activity. (共著)
21.	2019/12	論文	Interaction of Aripiprazole With Human α1-Acid Glycoprotein. J Pharm Sci. (共著)
22.	2019/11	論文	Enhanced dissolution and oral bioavailability of praziquantel by emulsification with human serum albumin followed by spray drying. Eur J Pharm Sci. (共著)
23.	2019/11	論文	α1-Acid Glycoprotein Has the Potential to Serve as a Biomimetic Drug Delivery Carrier for Anticancer Agents. J Pharm Sci. (共著)
24.	2019/06	論文	Investigation of anti-tumor effect of doxorubicin-loaded human serum albumin nanoparticles prepared by a desolvation technique. Cancer Chemother Pharmacol. (共著)
25.	2019/05	論文	Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin. J Pharm Sci. (共著)
26.	2019/02	論文	Apoptosis Induced by Ultraviolet A Exposure in the Presence of Enoxacin in HL-60 Cells. Anticancer Res. (共著)
27.	2018/12	論文	Glutamine Deprivation Enhances Acetyl-CoA Carboxylase Inhibitor-induced Death of Human Pancreatic Cancer Cells. Anticancer Res. (共著)
28.	2018/07	論文	Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites. Biochemistry and biophysics reports 14,155-160 (共著)
29.	2018/03	論文	Effect of endogenous substances on the binding of sodium 4-phenylbutyrate to human serum albumin. Acta Chim Pharm Indica (共著)
30.	2017/12	論文	Interaction of Protizinic Acid with Human Serum Albumin: Site-to-Site Displacement of Protizinic Acid by Ibuprofen. Acta Chim Pharm Indica (共著)
31.	2017/11	論文	Photodynamically-induced Apoptosis Due to Ultraviolet A in the Presence of Lomefloxacin in Human Promyelocytic Leukemia Cells. Anticancer research 37 (11),6407-6413 (共著)
32.	2017/11	論文	Enoxacin with UVA Irradiation Induces Apoptosis in the AsPC1 Human Pancreatic Cancer Cell Line Through ROS Generation. Anticancer research 37 (11),6211-6214 (共著)
33.	2017/09	論文	Recombinant Human Serum Albumin Containing 3 Copies of Domain I, Has Significant in Vitro Antioxidative Capacity Compared to the Wild-Type. Biological & pharmaceutical bulletin 40 (10),1813-1817 (共著)
34.	2017/06	論文	Long chain fatty acids alter the interactive binding of ligands to the two principal drug binding sites of human serum albumin. PloS one 12 (6),e0180404 (共著)
35.	2016/09	論文	Inhibition of Fatty Acid Synthesis Induces Apoptosis of Human Pancreatic Cancer Cells. Anticancer research 36 (9),4655-60 (共著)
36.	2016/05	論文	Antitumor effect of sonodynamically activated pyrrolidine tris-acid fullerene. (共著)
37.	2015/06	論文	Apoptosis induction by aluminum phthalocyanine tetrasulfonate-based sonodynamic therapy in HL-60 cells. Jpn J Appl Phys. (共著)
38.	2014/11	論文	Involvement of reactive oxygen species in the enhancement of membrane lipid peroxidation by sonodynamic therapy with functionalized fullerenes. Anticancer research 34 (11),6481-7 (共著)
39.	2014/04	論文	Acyl-coenzyme A:cholesterol acyltransferase 1 - significance of single-nucleotide polymorphism at residue 526 and the role of Pro347 near the fifth transmembrane domain. The FEBS journal 281 (7),1773-83 (共著)
40.	2013/08	論文	Sonodynamically-induced anticancer effects by functionalized fullerenes. Anticancer research 33 (8),3145-51 (共著)
41.	2013	論文	Molecular Aspects of Human Alpha-1 Acid Glycoprotein - Structure and Function. Acute Phase Proteins INTECH. Acute phase protein (共著)
42.	2012/09	論文	Involvement of reactive oxygen species in sonodynamically induced apoptosis using a novel porphyrin derivative. Theranostics 2 (9),880-8 (共著)
43.	2012/04	論文	Characterization of the hepatic cellular uptake of α(1) -acid glycoprotein (AGP), part 1: a peptide moiety of human AGP is recognized by the hemoglobin β-chain on mouse liver parenchymal cells. Journal of pharmaceutical sciences 101 (4),1599-606 (共著)
44.	2012/04	論文	Characterization of hepatic cellular uptake of α1-acid glycoprotein (AGP), part 2: involvement of hemoglobin β-chain on plasma membranes in the uptake of human AGP by liver parenchymal cells. Journal of pharmaceutical sciences 101 (4),1607-15 (共著)
45.	2011/04	論文	Structural insights into differences in drug-binding selectivity between two forms of human alpha1-acid glycoprotein genetic variants, the A and F1*S forms. The Journal of biological chemistry 286 (16),14427-34 (共著)
46.	2011/02	論文	Sonodynamically-induced antitumor effect of mono-l-aspartyl chlorin e6 (NPe6). Anticancer research 31 (2),501-6 (共著)
47.	2010/06	論文	Sonodynamically induced cell damage and membrane lipid peroxidation by novel porphyrin derivative, DCPH-P-Na(I). Anticancer research 30 (6),2241-6 (共著)
48.	2010/02	論文	Construction of an expression system for human alpha(1)-acid glycoprotein in E. coli: The roles of oligosaccharide moieties in structural and functional properties. Drug metabolism and pharmacokinetics 25 (2),200-7 (共著)
49.	2010/01	論文	Receptor-mediated uptake of human alpha1-acid glycoprotein into liver parenchymal cells in mice. Drug metabolism and pharmacokinetics 25 (1),101-7 (共著)
50.	2009/11	論文	A site-directed mutagenesis study of drug-binding selectivity in genetic variants of human alpha(1)-acid glycoprotein. Journal of pharmaceutical sciences 98 (11),4316-26 (共著)
51.	2007/11	論文	Structural and ligand-binding properties of serum albumin species interacting with a biomembrane interface. Journal of pharmaceutical sciences 96 (11),3117-24 (共著)
52.	2007/07	論文	Alpha1-acid glycoprotein suppresses rat acute inflammatory paw edema through the inhibition of neutrophils activation and prostaglandin E2 generation. Biological & pharmaceutical bulletin 30 (7),1226-30 (共著)
53.	2006/05	論文	Involvement of disulfide bonds and histidine 172 in a unique beta-sheet to alpha-helix transition of alpha 1-acid glycoprotein at the biomembrane interface. Proteins 63 (3),611-20 (共著)
54.	2005/10	論文	Characterization of benzodiazepine binding site on human alpha1-acid glycoprotein using flunitrazepam as a photolabeling agent. Biochimica et biophysica acta 1725 (3),385-93 (共著)
55.	2005/07	論文	Cooperative effect of hydrophobic and electrostatic forces on alcohol-induced alpha-helix formation of alpha1-acid glycoprotein. FEBS letters 579 (17),3596-600 (共著)
56.	2005/02	論文	Effect of genetic variation on the thermal stability of human serum albumin. Biochimica et biophysica acta 1747 (1),81-8 (共著)
57.	2005/01	論文	Use of photoaffinity labeling and site-directed mutagenesis for identification of the key residue responsible for extraordinarily high affinity binding of UCN-01 in human alpha1-acid glycoprotein. The Journal of biological chemistry 280 (2),1384-91 (共著)
58.	2004/10	論文	Construction of expression system for human alpha 1-acid glycoprotein in Pichia pastoris and evaluation of its drug-binding properties. Drug metabolism and disposition: the biological fate of chemicals 32 (10),1069-74 (共著)
59.	2004/09	論文	Tryptophan residues play an important role in the extraordinarily high affinity binding interaction of UCN-01 to human alpha-1-acid glycoprotein. Pharmaceutical research 21 (9),1648-55 (共著)
60.	2004/08	論文	Binding of alpha1-acid glycoprotein to membrane results in a unique structural change and ligand release. Biochemistry 43 (32),10513-9 (共著)
61.	2002/12	論文	Structural and drug-binding properties of alpha(1)-acid glycoprotein in reverse micelles. Biochimica et biophysica acta 1601 (2),185-91 (共著)
62.	2002/12	論文	Characterization of ligand binding sites on the alpha1-acid glycoprotein in humans, bovines and dogs. Drug metabolism and pharmacokinetics 17 (4),300-6 (共著)
63.	2000/04	論文	Characterization of a binding site of UCN-01, a novel anticancer drug on alpha-acid glycoprotein (共著)