教員情報 - 下野　和実

シモノ　カズミ Shimono Kazumi
下野　和実

所属薬学部薬学科

職種教授

著書・論文歴
1.	2023/01	論文	Recent advances in signaling and activation mechanism in microbial rhodopsins: Report for the session 6 at the 19th International Conference on Retinal Proteins Biophysics and Physicobiology,e201009 (共著)
2.	2022/04	論文	Estimation of the Diffusion Coefficients of Small Molecules by Diffusion Measurements with Agar-gel and Theoretical Molecular Modeling Chem-Bio Informatics Journal 22,13-20頁 (共著)
3.	2021/05	論文	Protonation state of a histidine residue in human oligopeptide transporter 1 (hPEPT1) regulates hPEPT1-mediated efflux activity Biological and Pharmaceutical Bulletin 44 (59),678-685頁 (共著)
4.	2020/11	論文	Molecular Modeling to Estimate the Diffusion Coefficients of Drugs and Other Small Molecules Molecules 25 (22),5340 (共著)
5.	2019/02	論文	Transport of 2,4-dichloro phenoxyacetic acid by human Na⁺-coupled monocarboxylate transporter 1 (hSMCT1, SLC5A8) Drug Metabolism and Pharmacokinetics 34 (1),95-103頁 (共著)
6.	2018/06	論文	Production of a Light-Gated Proton Channel by Replacing the Retinal Chromophore with Its Synthetic Vinylene Derivative J Phys Chem Lett 9 (11),2857-2862頁 (共著)
7.	2018/06	論文	Interhelical interactions between D92 and C218 in the cytoplasmic domain regulate proton uptake upon N-decay in the proton transport of Acetabularia rhodopsin II J Photochem Photobiol B 183,35-45頁 (共著)
8.	2018/03	論文	The phenomenon of albumin-mediated hepatic uptake of organic anion transport polypeptide substrates: Prediction of the in vivo uptake clearance from the in vitro uptake by isolated hepatocytes using a facilitated-dissociation model Drug Metabolism and Disposition 46 (3),259-267頁 (共著)
9.	2017/09	論文	Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy Biochemical Journal 474 (20),3391-3402頁 (共著)
10.	2017/03	論文	Existence of two O-like intermediates in the photocycle of Acetabularia rhodopsin II, a light-driven proton pump from a marine alga Biophysics and Physicobiology 14,49-55頁 (共著)
11.	2016/10	論文	Crystal structures of the ATP-binding and ADP-release dwells of the V1 rotary motor Nature Communications 7,13235 (共著)
12.	2016/08	著書	Cell-free synthesis of membrane proteins Advanced Methods in Structural Biology,123-135頁 (共著)
13.	2016/06	論文	X-ray Crystallographic Structure of Thermophilic Rhodopsin: Implications for High Thermal Stability and Optogenetic Function Journal of Biological Chemistry 291 (23),12223-12232頁 (共著)
14.	2015/11	論文	Structural Basis for Slow Photocycle and Late Proton Release in Acetabularia Rhodopsin I from a Marine Plant, Acetabularia acetabulum Acta Crystallographica Section D: Biological Crystallography 71 (11),2203-2216頁 (共著)
15.	2015/03	論文	Converting a light-driven proton pump into a light-gated ion channel Journal of American Chemical Society 137 (9),3291-3299頁 (共著)
16.	2014/11	論文	Electrophysiological characterization of human Na+/taurocholate cotransporting polypeptide (hNTCP) heterologously expressed in Xenopus laevis oocytes Archives of Biochemistry and Biophysics 562,115-121頁 (共著)
17.	2014/01	論文	A common variant of leucine-rich repeat containing 16A (LRRC16A) gene is associated with gout susceptibility Human Cell 27 (1),1-4頁 (共著)
18.	2013/04	著書	調製困難なロドプシン類の機能的大量合成法オプトジェネティクス～光工学と遺伝子による行動制御技術の最前線～,45-54頁 (共著)
19.	2013/02	論文	A study of the interaction of drugs with liposomes with isothermal titration calorimetry Jouranl of Biophysical Chemistry 4 (1),11-21頁 (共著)
20.	2013/02	論文	Thermodynamic Parameters of Anion Binding to Halorhodopsin from Natronomonas pharaonis by Isothermal Titration Calorimetry Biophysical Chemistry 172,61-67頁 (共著)
21.	2012/11	論文	The Photo-induced Proton Release in Proteorhodopsin at Low pH: The Possibility of the pKa Decrease of Asp227 Biochemistry 51 (46),9290-9301頁 (共著)
22.	2012/03	著書	Photoinduced Proton Transfers of Microbial Rhodopsins Molecular Photochemistry - Various Aspects,89-108頁 (共著)
23.	2011/10	論文	Photochemistry of Acetabularia Rhodopsin II from a Marine Plant, Acetabularia acetabulum Biochemistry 50 (41),8888-8898頁 (共著)
24.	2011/09	論文	Crystal structure of the eukaryotic light-driven proton pumping rhodopsin, Acetabularia rhodopsin II from marine alga Journal of Molecular Biology 411 (5),986-998頁 (共著)
25.	2011/05	論文	無細胞タンパク質合成による膜タンパク質の生産生物物理 51 (3),128-129頁 (共著)
26.	2011/01	論文	Photochemistry of a Putative New Class of Sensory Rhodopsin (SRIII) coded by xop2 of Haloarcular marismortui Journal of Photochemistry and Photobiology B-Biology 102,45-54頁 (共著)
27.	2010/07	論文	無細胞タンパク質合成系を活用した膜タンパク質合成方法実験医学 28,1775-1780頁 (共著)
28.	2010/06	論文	無細胞タンパク質合成系を活用した膜タンパク質合成法の開発バイオインダストリー 27,55-63頁 (共著)
29.	2009/10	論文	Production of functional bacteriorhodopsin by an Escherichia coli cell-free protein synthesis system supplemented with steroid detergent and lipid Protein Science 18 (10),2160-2171頁 (共著)
30.	2008/07	論文	A long-lived M-like state of phoborhodopsin that mimics the active state Biophysical Journal 95 (2),753-760頁 (共著)
31.	2007/03	論文	Participation of the surface structure of Pharaonis phoborhodopsin, ppR and its A149S and A149V mutants, consisting of the C-terminal alpha-helix and E-F loop, in the complex-formation with the cognate transducer pHtrII, as revealed by site-directed C-13 solid-state NMR Photochemistry and Photobiology 83 (2),339-345頁 (共著)
32.	2006/10	論文	Assignment of the hydrogen-out-of-plane and -in-plane vibrations of the retinal chromophore in the K intermediate of pharaonis phoborhodopsin Biochemistry 45 (39),11836-11843頁 (共著)
33.	2006/04	論文	Importance of specific hydrogen bonds of archaeal rhodopsins for the binding to the transducer protein Journal of Molecular Biology 357 (4),1274-1282頁 (共著)
34.	2005/09	論文	Hydrogen-bonding alterations of the protonated Schiff base and water molecule in the chloride pump of Natronobacterium pharaonis Biochemistry 44 (37),12279-12286頁 (共著)
35.	2005/08	論文	Formation of a long-lived photoproduct with a deprotonated Schiff base in proteorhodopsin, and its enhancement by mutation of Asp227 Biochemistry 44 (32),10828-10838頁 (共著)
36.	2005/03	論文	Structural changes of the complex between pharaonis phoborhodopsin and its cognate transducer upon formation of the m photointermediate Biochemistry 44 (8),2909-2915頁 (共著)
37.	2005/02	論文	Correlation of the O-intermediate rate with the pK(a) of Asp-75 in the dark, the counterion of the Schiff base of Pharaonis phoborhodopsin (sensory rhodopsin II) Biophysical Journal 88 (2),1215-1223頁 (共著)
38.	2004/11	論文	Role of charged residues of pharaonis phoborhodopsin (sensory rhodopsin II) in its interaction with the transducer protein Biochemistry 43 (43),13748-13754頁 (共著)
39.	2004/08	論文	Amino acid residues regulating the color among archaeal rhodopsins Recent Research Developments in Photochemistry and Photobiology 7,19-38頁 (共著)
40.	2004/06	論文	Transient movement of helix F revealed by photo-induced inactivation by reaction of a bulky SH-reagent to cysteine-introduced pharaonis phoborhodopsin (sensory rhodopsin II) Photochemical & Photobiological Sciences 3 (6),537-542頁 (共著)
41.	2004/05	論文	FTIR spectroscopy of the O photointermediate in pharaonis phoborhodopsin Biochemistry 43 (18),5204-5212頁 (共著)
42.	2004/05	論文	Role of Arg-72 of pharaonis phoborhodopsin (sensory rhodopsin II) on its photochemistry Biophysical Journal 86 (5),3112-3120頁 (共著)
43.	2004/05	論文	Conformation and dynamics of the [3-C-13]Ala,[1-C-13]val-labeled truncated pharaonis transducer, pHtrII(1-159), as revealed by site-directed C-13 solid-state NMR: Changes due to association with phoborhodopsin (sensory rhodopsin II) Biophysical Journal 86 (5),3131-3140頁 (共著)
44.	2004/03	論文	Proton release and uptake of pharaonis phoborhodopsin (Sensory rhodopsin II) reconstituted into phospholipids Biochemistry 43 (11),3195-3203頁 (共著)
45.	2003/12	論文	Hydrogen bonding alteration of Thr-204 in the complex between pharaonis phoborhodopsin and its transducer protein Biochemistry 42 (48),14166-14172頁 (共著)
46.	2003/11	論文	Interaction of Natronobacterium pharaonis phoborhodopsin (sensory rhodopsin II) with its cognate transducer probed by increase in the thermal stability Photochemistry and Photobiology 78 (5),511-516頁 (共著)
47.	2003/07	論文	Roles of Ser130 and Thr126 in chloride binding and photocycle of pharaonis halorhodopsin Journal of Biochemistry 134 (1),151-158頁 (共著)
48.	2003/07	論文	Ser-130 of Natronobacterium pharaonis halorhodopsin is important for the chloride binding Biophysical Chemistry 104 (1),209-216頁 (共著)
49.	2003/06	論文	Importance of the broad regional interaction for spectral tuning in Natronobacterium pharaonis phoborhodopsin (sensory rhodopsin II) Journal of Biological Chemistry 278 (26),23882-23889頁 (共著)
50.	2003/05	論文	Vibrational modes of the protonated Schiff base in pharaonis phoborhodopsin Biochemistry 42 (25),7801-7806頁 (共著)
51.	2003/02	論文	Dynamic structure of pharaonis phoborhodopsin (sensory rhodopsin II) and complex with a cognate truncated transducer as revealed by site-directed C-13 solid-state NMR FEBS Letters 536,237-240頁 (共著)
52.	2003/01	論文	Arg-72 of pharaonis phoborhodopsin (Sensory rhodopsin II) is important for the maintenance of the protein structure in the solubilized state Photochemistry and Photobiology 77 (1),96-100頁 (共著)
53.	2002/11	論文	フォボロドプシンを介する古細菌の光情報認識機構生物物理 42 (6),290-294頁 (共著)
54.	2002/12	論文	FTIR spectroscopy of the M photointermediate in pharaonis phoborhodopsin Biophysical Journal 83 (6),3482-3489頁 (共著)
55.	2002/10	論文	Illumination accelerates the decay of the o-intermediate of pharaonis phoborhodopsin (sensory rhodopsin II) Photochemistry and Photobiology 76 (4),462-466頁 (共著)
56.	2002/08	論文	Role of Asp193 in chromophore-protein interaction of pharaonis phoborhodopsin (sensory rhodopsin II) Biophysical Journal 83 (2),1130-1135頁 (共著)
57.	2002/07	論文	Association between a photo-intermediate of a M-lacking mutant D75N of pharaonis phoborhodopsin and its cognate transducer Journal of Photochemistry and Photobiology B-Biology 67 (3),171-176頁 (共著)
58.	2002/07	論文	Tyr-199 and charged residues of pharaonis phoborhodopsin are important for the interaction with its transducer Biophysical Journal 83 (1),427-432頁 (共著)
59.	2002/05	論文	A pharaonis phoborhodopsin mutant with the same retinal binding site residues as in bacteriorhodopsin Biochemistry 41 (20),6504-6509頁 (共著)
60.	2002/04	論文	Probing the proton channel and the retinal binding site of Natronobacterium pharaonis sensory rhodopsin II Biophysical Journal 82 (4),2156-2164頁 (共著)
61.	2002/04	論文	Interaction of Asn105 with the retinal chromophore during photoisomerization of pharaonis phoborhodopsin Biochemistry 41 (14),4554-4559頁 (共著)
62.	2002/01	論文	Association of pharaonis phoborhodopsin with its cognate transducer decreases the photo-dependent reactivity by water-soluble reagents of azide and hydroxylamine Biochimica et Biophysica Acta-Biomembranes 1558 (1),63-69頁 (共著)
63.	2001/11	論文	Photochemistry and photoinduced proton-transfer by pharaonis phoborhodopsin Biochemistry-Moscow 66 (11),1277-1282頁 (共著)
64.	2001/12	論文	Internal water molecules of pharaonis phoborhodopsin studied by low-temperature infrared Spectroscopy Biochemistry 40 (51),15693-15698頁 (共著)
65.	2001/12	論文	Environment around the chromophore in pharaonis phoborhodopsin: mutation analysis of the retinal binding site Biochimica et Biophysica Acta-Biomembranes 1515 (2),92-100頁 (共著)
66.	2001/09	論文	Pharaonis phoborhodopsin binds to its cognate truncated transducer even in the presence of a detergent with a 1 : 1 stoichiometry Photochemistry and Photobiology 74 (3),489-494頁 (共著)
67.	2001/09	論文	Selective reaction of hydroxylamine with chromophore during the photocycle of pharaonis phoborhodopsin Biochimica et Biophysica Acta-Biomembranes 1514 (1),152-158頁 (共著)
68.	2001/08	論文	Structural changes of pharaonis phoborhodopsin upon photoisomerization of the retinal chromophore: Infrared spectral comparison with bacteriorhodopsin Biochemistry 40 (31),9238-9246頁 (共著)
69.	2001/02	論文	Photo-induced proton transport of Pharaonis phoborhodopsin (sensory rhodopsin II) is ceased by association with the transducer Biophysical Journal 80 (2),916-922頁 (共著)
70.	2000/10	論文	Involvement of two groups in reversal of the bathochromic shift of pharaonis phoborhodopsin by chloride at low pH Biophysical Chemistry 87,225-230頁 (共著)
71.	2000/07	論文	Effects of three characteristic amino acid residues of Pharaonis phoborhodopsin on the absorption maximum Photochemistry and Photobiology 72 (1),141-145頁 (共著)
72.	1999/11	論文	Light-induced proton uptake and release of pharaonis phoborhodopsin detected by a photoelectrochemical cell Journal of Physical Chemistry B 103 (46),10311-10315頁 (共著)
73.	1999/06	論文	Positioning proton-donating residues to the Schiff-base accelerates the M-decay of pharaonis phoborhodopsin expressed in Escherichia coli Biophysical Chemistry 79 (3),187-192頁 (共著)
74.	1998/08	論文	V108M mutant of pharaonis phoborhodopsin: Substitution caused no absorption change but affected its M-state Journal of Biochemistry 124 (2),404-409頁 (共著)
75.	1997/12	論文	Functional expression of pharaonis phoborhodopsin in Escherichia coli FEBS Letters 420 (1),54-56頁 (共著)