教員情報 - 安楽　誠

アンラク　マコト Anraku Makoto
安楽　誠

所属薬学部薬学科

職種教授

著書・論文歴
1.	2022	著書	Utilization of agro-industrial and food by-products for the production of amphiphilic proteins and peptides Elisevier (共著)
2.	2022	論文	The Effects of Sacran, a Sulfated Polysaccharide, on Gut Microbiota Using Chronic Kidney Disease Model Rats Biological & Pharmaceutical Bulletin (共著)
3.	2021	論文	Supramolecular Assembly of Hybrid Pt(II) Porphyrin/Tomatine Analogues with Different Nanostructures and Cytotoxic Activities ACS Omega (共著)
4.	2021	論文	Interspecies differences in gastrointestinal physiology affecting the in vivo performance of oral pharmaceutical solid dosage forms Journal of Drug Delivery Science and Technology (共著)
5.	2021	著書	Preparation of Chitin Nanofiber and Its Derivatives from Crab Shell and Their Efficient Biological Properties In book: Chitosan for Biomaterials III (共著)
6.	2021	論文	Sacran, a sulfated polysaccharide, suppresses the absorption of lipids and modulates the intestinal flora in non-alcoholic steatohepatitis model rats 268,118991 (共著)
7.	2021	論文	The preparation and validation of chitosan tablets that rapidly disperse and disintegrate as an oral adsorbent in the treatment of lifestyle-related diseases Carbohydr Polym . 123,117246 (共著)
8.	2020	論文	Antioxidative Potency of Dolphin Serum Albumin Is Stronger Than That of Human Serum Albumin Irrespective of Substitution of 34Cysteine With Serine Frontiers in Physiology (共著)
9.	2020	論文	A Comparison of the Frequency of Prescription and Pharmacy Revisits between Baloxavir Marboxil and Neuraminidase Inhibitors in Influenza-Infected Pediatric Patients during the 2019-2020 Influenza Season Biol Pharm Bull . 43 (12),1960-1965頁 (共著)
10.	2020	論文	Antioxidative Potency of Dolphin Serum Albumin Is Stronger Than That of Human Serum Albumin Irrespective of Substitution of 34 Cysteine With Serine Front Physiol . 2 (11),598451 (共著)
11.	2020	論文	Glycosylation decreases aggregation and immunogenicity of adalimumab fab secreted from Pichia pastoris J Biochem. (共著)
12.	2020	著書	Handbook of chitin and chitosan; vol.3: chitin and chitosan based polymer materials for various applications -Chapter 18 - Future aspects of biomedical applications of chitin and chitosan in diseases associated with oxidative stress- Science direct,589-608頁 (共著)
13.	2020	論文	非アルコール性脂肪肝炎(NASH)モデルラットに対する表面脱アセチル化キチンナノファイバーの効果 Chitin and chitosan research 26 (1),54-54頁 (共著)
14.	2020	論文	Effects of surface-deacetylated chitin nanofibers on non-alcoholic steatohepatitis model rats and their gut microbiota International journal of biological macromolecule 164,659-666頁 (共著)
15.	2020	論文	A thermoresponsive hydrophobically modified hydroxypropylmethylcellulose/cyclodextrin injectable hydrogel for the sustained release of drugs International Journal of Pharmaceutics (Amsterdam, Netherlands) 575,118845 (共著)
16.	2020	論文	C-Terminal Cysteine PEGylation of Adalimumab Fab with an Engineered Interchain SS Bond Biological & pharmaceutical bulletin 43 (3),418-423頁 (共著)
17.	2020	論文	Evaluation of the Usefulness of a Completely Separated Infection Waiting Room and Non-infection Waiting Room in a Pediatric Neighborhood Pharmacy Yakugaku zasshi 140 (4),585-589頁 (共著)
18.	2020	論文	Morphometric analysis of paramylon particles produced by Euglena gracilis EOD-1 using FIB/SEM tomography Chemical & pharmaceutical bulletin (共著)
19.	2020	論文	In vitro transdermal permeation behavior of isosorbide dinitrate in the absence and presence of 2-hydroxypropyl-β-cyclodextrin: solutions and suspensions Journal of Inclusion Phenomena and Macrocyclic Chemistry (共著)
20.	2019	論文	Design and Evaluation of An Extended-Release Olmesartan Tablet Using Chitosan/Cyclodextrin Composites Pharmaceutics 11,82 (共著)
21.	2019	その他	Pharmaceutical formulation of antioxidant therapy utilizing complementary substitutes for chronic renal failure Yakugaku Kenkyu no Shinpo 35,81-86頁 (単著)
22.	2019	論文	表面脱アセチル化キチンナノファイバーを利用した医薬への応用 Cellulose Commun (単著)
23.	2019	論文	The Use of Enteric Capsules for Releasing a Fragrance over an Extended Period of Tim Chemical & pharmaceutical bulletin 67 (5),493-497頁 (共著)
24.	2019	論文	Modification of Drug Crystallization by Cyclodextrins in Pre-Formulation Study Chem. Pharm. Bull (共著)
25.	2019	論文	Physiologically Stable Hydrophilic C60 Nanoparticles for Photodynamic Therapy 2,716-725頁 (共著)
26.	2019	論文	Preparation and evaluation of freeze dried surface-deacetylated chitin nanofiber/sacran pellets for use as an extended-release excipient Int. J. Biol. Macromol 124,888-894頁 (共著)
27.	2018	著書	医薬品・サプリメント中の無機リン含量とその考え方薬局 69 (共著)
28.	2018	論文	Antioxidant activities of chitosans and its derivatives in in vitro and in vivo studies. Carbohydr Polym 199,141-149頁 (共著)
29.	2018	論文	Sacran, a High-molecular Weight Polysaccharide Inhibits Renal Injury and Oxidative Stress in Chronic Renal Failure Model Rats Journal of Nutritional Biology 4,267-275頁 (共著)
30.	2018	論文	Metal-catalyzed oxidation of human serum albumin does not alter the interactive binding to the two principal drug binding sites. Biochem Biophys Rep 14,155-160頁 (共著)
31.	2018	論文	Release control of fragrances by complexation with β-cyclodextrin and its derivatives Journal of Inclusion Phenomena and Macrocyclic Chemistry 92(1-2),147-155頁 (共著)
32.	2018	論文	Glucose Responsive Rheological Change and Drug Release from a Novel Worm-like Micelle Gel Formed in Cetyltrimethylammonium Bromide/Phenylboronic Acid/Water System. Mol Pharm. (共著)
33.	2018	論文	透析患者が服用するサプリメント，漢方製剤中の無機リン含有量に関する研究医療薬学 (共著)
34.	2017	論文	Surface-deacetylated chitin nanofibers reinforced with a sulfobutyl ether β-cyclodextrin gel loaded with prednisolone as potential therapy for inflammatory bowel disease. Carbohydr Polym. (共著)
35.	2017	論文	The binding of silibinin, the main constituent of silymarin, to site I on human serum albumin Biological & Pharmaceutical Bulletin (共著)
36.	2017	論文	Hydrophobically Modified Polymer/α-Cyclodextrin Thermoresponsive Hydrogels for Use in Ocular Drug Delivery. Mol Pharm. (共著)
37.	2017	論文	A Comparison of the Phosphorus Content in Prescription Medications for Hemodialysis Patients in Japan. Yakugaku Zasshi (共著)
38.	2017	論文	Crystallographic analysis of the ternary complex of octanoate and N-acetyl-l-methionine with human serum albumin reveals the mode of their stabilizing interactions. Biochim Biophys Acta (共著)
39.	2017	論文	An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats. Carbohydr Polym (共著)
40.	2017	論文	シクロデキストリン/キトサンナノファイバーコンポジットゲルの徐放性素材への応用キチンキトサン研究 (共著)
41.	2017	著書	第1 0章生体吸収性材料としてのゲル開発第1節シクロデキストリン/表面脱アセチル化キチンナノファイバー複合ゲルの創傷治癒への応用 (共著)
42.	2017	著書	第８章　「ドラッグデリバリー機能のある」ゲルの調製・開発第２節　シクロデキストリン/表面脱アセチル化キチンナノファイバー複合ゲルの薬物徐放性製剤への応用 (共著)
43.	2017	著書	第１章各種ゲル化・増粘剤としての特性と活用事例　第15節 HM-HPMC（疎水化ヒドロキシプロピルメチルセルロース） (共著)
44.	2016	論文	The formation of an inclusion complex between a metabolite of ginsenoside, compound K and γ-cyclodextrin and its dissolution characteristics. J Pharm Pharmacol (共著)
45.	2016	論文	Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations Journal of Pharmaceutical Sciences (共著)
46.	2016	論文	Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats. J Pharm Pharmacol (共著)
47.	2016	論文	Antioxidant effects of the hydroxy groups in the simple phenolic carbazoles Heterocycles 92,120-132頁 (共著)
48.	2016	論文	Biomaterials based on freeze dried surface-deacetylated chitin nanofibers reinforced with sulfobutyl ether β-cyclodextrin gel in wound dressing applications Int. J. Pharm 511,1080-1087頁 (共著)
49.	2016	論文	Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study Biol. Pharm. Bull 39,1000-1006頁 (共著)
50.	2016	論文	In Vitro and In Vivo Evaluation of Hydrophilic C60(OH)10/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as an Antioxidant J. Pharm. Sci 105,2959-2965頁 (共著)
51.	2016	論文	N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl-L-tryptophan Biochim. Biophys. Rep 68,608-614頁 (共著)
52.	2016	著書	キチン・キトサンの最新科学技術「キトサンの抗酸化作用を利用した酸化ストレス関連疾患への応用」,192-207頁 (共著)
53.	2016	論文	キトサンの多面的作用を利用した医薬への応用キチン・キトサン研究,51-58頁 (単著)
54.	2015	論文	Surface-Deacetylated Chitin Nano-Fiber/Hyaluronic Acid Composites as Potential Antioxidative Compounds for Use in Extended-Release Matrix Tablets. Int J Mol Sci 16,24707-24717頁 (共著)
55.	2015	論文	Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants. Life Sci 134,36-41頁 (共著)
56.	2015	論文	Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury. Clin Exp Nephrol. (共著)
57.	2015	論文	Slow-release of famotidine from tablets consisting of chitosan/sulfobutyl ether β-cyclodextrin composites. Int J Pharm 487,142-147頁 (共著)
58.	2015	論文	Formation of Elastic Gels from Deacetylated Chitin Nanofibers Reinforced with Sulfobutyl Ether β-Cyclodextrin Chemistry Letters 44,285-287頁 (共著)
59.	2015	論文	Preparation of hydrophilic C60(OH)10/2-hydroxypropyl-β-cyclodextrin nanoparticles for the treatment of a liver injury induced by an overdose of acetaminophen. Biomaterials 45,115-123頁 (共著)
60.	2015	論文	Cross-linked human serum albumin dimer has the potential for use as a plasma-retaining agent for the fatty acid-conjugated antidiabetic drugs. J Pharm Pharmacol 67,255-63頁 (共著)
61.	2015	著書	Human Serum Albumin (HSA): Functional Structure, Synthesis and Therapeutic Uses; Glycative and Oxidative Modification of Human Serum Albumin (Chapter 5),91-112頁 (共著)
62.	2014	論文	Pleiotropic effects of chitosan on lifestyle-related diseases Kichin, Kitosan Kenkyu 20 (2),74-81頁 (共著)
63.	2014	論文	Elucidation of the mechanism responsible for the oxidation of serum albumin and its application in treating oxidative stress-related diseases Yakugaku Zasshi 134 (9),973-970頁 (単著)
64.	2014	論文	Effects of chitosan on oxidative stress and related factors in hemodialysis patients Carbohydr Poly 112,152-157頁 (共著)
65.	2014	論文	N-acetyl-L- methionine is a superior protectant of human serum albumin against photo- oxidation and reactive oxygen species compared to N-acetyl-L-tryptophan Biochim Biophys Acta (共著)
66.	2014	論文	Potential Use of /2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer International Journal of Photoenergy (共著)
67.	2014	論文	Preparation and antioxidant activity of PEGylated chitosans with different particle sizes Int J Biol Macromol (共著)
68.	2014	論文	Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles Bioorg Med Chem Lett (共著)
69.	2014	論文	Combined use of cyclodextrins and hydroxypropylmethylcellulose stearoxy ether (Sangelose) for the preparation of orally disintegrating tablets of type-2 antidiabetes agent glimepiride Journal of Inclusion Phenomena and Macrocyclic Chemistry (共著)
70.	2014	論文	Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases PLoS One (共著)
71.	2014	論文	Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin PLoS One (共著)
72.	2013	論文	Crystallization of a new polymorph of acetohexamide from 2- hydroxybutyl- β-cyclodextrin solution: form VI with a high aqueous solubility Int J Pharm 453,315-321頁 (共著)
73.	2013	著書	Human serum albumin: The oxidation of human serum albumin and role of Cys34,180-196頁 (共著)
74.	2013	論文	Preparation of soluble stable C60-human serum albumin nanoparticles via cyclodextrin complexation and their reactive oxygen production characteristics Life Sci 93,277-272頁 (共著)
75.	2013	論文	Redox properties of serum albumin Biochim Biophys Acta 1830,5465-5472頁 (共著)
76.	2013	著書	シクロデキストリンの科学と技術; 「薬物の各種製剤特性改善におけるシクロデキストリンの有用性」,124-133頁 (共著)
77.	2012	論文	Antioxidant and renoprotective activity of chitosan in nephrectomized rats Carbohydr Poly 89,302-304頁 (共著)
78.	2012	論文	Cyclodextrin-induced change in crystal habit of acetylsalicylic acid in aqueous solution Crystal Growth & Design 12,1985-1991頁 (共著)
79.	2012	論文	Effect of the Similarity in Appearance of PTP Packaging between Original and Generic Drug Products on Safety Management for Medication Jpn J Pharmaceut Health Care Sci 38,18-24頁 (共著)
80.	2011	論文	Antioxidant properties of high molecular weight dietary chitosan in vitro and in vivo Carbohydr Poly 83,501-505頁 (共著)
81.	2011	論文	Comparison of receptors and enzymes regulating cholesterol levels in liver between SHR/NDmcr-cp rats and normotensive Wistar Kyoto rats at ten weeks of age Biol Pharm Bull 34,1116-1119頁 (共著)
82.	2011	論文	Quantitative analysis of cysteine-34 on the anitioxidative properties of human serum albumin in hemodialysis patients J Pharm Sci 100,3968-3976頁 (共著)
83.	2011	論文	Spectroscopic studies of interactions of chondroitin sulfates with cisplatin Carbohydr Res 346,631-637頁 (共著)
84.	2011	論文	Surveillance study on the needs for self-medication of local residents and community pharmacists in Fukuyama Yakugaku Zasshi 131,1117-1125頁 (共著)
85.	2011	論文	Surveillance study on use of over-the-counter drug and health food by school pharmacist for grade-schooler, junior high school student, and high school students. Yakugaku Zasshi 131,835-842頁 (共著)
86.	2010	論文	Enhancement of dissolution and bioavailability of flurbiprofen by low molecular weight chitosans Pharmazie 64,461-466頁 (共著)
87.	2010	論文	Evaluation of carboxymethyl-β-cyclodextrin with acid function: Improvement of chemical stability, oral bioavailability and bitter taste of famotidine Int J Pharm 397,1-8頁 (共著)
88.	2010	論文	High Levels of Oxidative Stress in the Brain of Young Stroke-Prone Spontaneously Hypertensive Rats at Ten Weeks of Age Biol Pharm Bull 33,518-521頁 (共著)
89.	2010	論文	Polysaccharides as potential antioxidative compounds for extended-release matrix tablets Carbohydr Res 345,82-86頁 (共著)
90.	2010	論文	Superior plasma retention of a cross-linked human serum albumin dimer in nephrotic rats as a new type of plasma expander Drug Metab Dispos 38,2124-2129頁 (共著)
91.	2010	論文	The antioxidative and antilipidemic effects of different molecular weight chitosans in metabolic syndrome model rats Biol Pharm Bull 33,1994-1998頁 (共著)
92.	2010	論文	Useful Extend-release Chitosan Tablets with High Antioxidant Activity Pharmaceutics 2,245-257頁 (共著)
93.	2010	論文	プライマリケア薬剤師によるヘルスプロモーション－葉酸摂取における認知度調査と能動的情報提供の効果医療薬学 36,533-541頁 (共著)
94.	2010	論文	一般用医薬品におけるユニバーサルデザインの現状と高齢者における有用性評価医療薬学 36,557-567頁 (共著)
95.	2010	論文	各分子量キトサンの抗酸化作用キチン・キトサン研究 16,51-58頁 (共著)
96.	2010	論文	福山大学薬学部における幼児・高齢者との交流学習への取り組み－学生のコミュニケーションおよびホスピタリティ能力を培うために－医療薬学 36,523-530頁 (共著)
97.	2010	論文	福山市における大学－高齢者及び保育施設連携を活用した一般用医薬品・健康食品利用実態に関する調査研究薬誌 130,1093-1103頁 (共著)
98.	2009	論文	Antioxidant effects of a dietary supplement: reduction of indices of oxidative stress in normal subjects by water-soluble chitosan Food Chem Toxicol 47,104-109頁 (共著)
99.	2009	論文	Antioxidant properties of some different molecular weight chitosans Carbohydr Res 344,1690-1696頁 (共著)
100.	2009	論文	Evaluation for antioxidant and renoprotective activity of olmesartan using nephrectomy rats Biol Pharm Bull 32,2041-2045頁 (共著)
101.	2009	論文	Hemoglobin vesicles, polyethylene glycol (PEG)ylated liposomes developed as a red blood cell substitute, do not induce the accelerated blood clearance phenomenon in mice Drug Metab Dispos 37,2197-2203頁 (共著)
102.	2009	論文	Pharmacokinetic study of enclosed hemoglobin and outer lipid component after the administration of hemoglobin vesicles as an artificial oxygen carrier Drug Metab Dispos 37,1456-1463頁 (共著)
103.	2009	論文	大学・ドラッグストア連携を活用した備後地域における健康食品・一般用医薬品利用実態に関する調査研究医療薬学 35,487-494頁 (共著)
104.	2008	論文	Antioxidant protection of human serum albumin by chitosan Int J Biol Macromol 43,159-164頁 (共著)
105.	2008	論文	CD36 is one of important receptors promoting renal tubular injury by advanced oxidation protein products Am J Physiol Renal Physiol 295,F1871-1880頁 (共著)
106.	2008	論文	Effect of intravenous iron administration frequency on AOPP and inflammatory biomarkers in chronic hemodialysis patients: a pilot study Clin Biochem 41,1168-1174頁 (共著)
107.	2007	論文	An oral adsorbent, AST-120 protects against the progression of oxidative stress by reducing the accumulation of indoxyl sulfate in the systemic circulation in renal failure . Pharm Res 24,1283-1289頁 (共著)
108.	2007	論文	Changes of net charge and α-helical content affect the pharmacokinetic properties of human serum albumin. Biochim Biophys Acta 1774,1582-1590頁
109.	2007	論文	Effect of olmesartan on oxidative stress in hemodialysis patients Hypertens Res 30,395-402頁 (共著)
110.	2007	論文	The role of N-acetyl-methioninate as a new stabilizer for albumin products Int J Pharm 329,19-24頁 (共著)
111.	2007	著書	マウスを用いた研究─アイソトープを用いたタンパク質の体内動態評価法：RI の逆襲アイソトープを活用した簡単・安全バイオ実験細胞工学,132-137頁 (共著)
112.	2006	論文	Chromium(III) ion and thyroxine cooperate to stabilize the transthyretin tetramer and suppress in vitro amyloid fibril formation FEBS Lett 580,491-496頁 (共著)
113.	2006	論文	Oxidation of Arg-410 promotes the elimination of human serum albumin Biochim Biophys Acta 1764,743-749頁 (共著)
114.	2006	論文	The structural and pharmacokinetic properties of oxidized human serum albumin, advanced oxidation protein products (AOPP) Drug Metab Pharmacokinet 21,140-146頁 (共著)
115.	2006	論文	保険薬局におけるポピュレーションファーマコキネティクス解析の有用性評価－オランザピンの投与量に及ぼす喫煙と性差の影響医療薬学 32,940-945頁 (共著)
116.	2005	論文	Effect of genetic variation on the thermal stability of human serum albumin Biochim Biophys Acta 1747,81-88頁 (共著)
117.	2005	論文	Effect of telmisartan on ABPM, plasma BNP, and oxidative status of serum albumin in hemodialysis patients Hypertens Res 28,987-994頁 (共著)
118.	2005	論文	Hydrolysis of angiotensin II receptor blocker prodrug olmesartan medoxomil by human serum albumin and identification of its catalytic active sites Drug Metab Dispos 33,1911-1919頁 (共著)
119.	2005	論文	Oxidation and carboxyl methyl lysine (CML)-modification of albumin; possible involvement in the progression of oxidative stress in hemodialysis patients Hypertens Res 28,973-980頁 (共著)
120.	2005	論文	The structure and function of oxidized albumin in hemodialysis patients: Its role in elevated oxidative stress via neutrophil burst Biochem Biophys Res 334,1322-1328頁 (共著)
121.	2005	論文	天然高分子サプリメントに対する薬物の結合性評価医療薬学 31,744-748頁 (共著)
122.	2005	論文	血清アルブミンの構造特性と医薬への応用人工血液 Vol.13,22-28 (共著)
123.	2004	論文	Intravenous iron administration induces oxidation of serum albumin in hemodialysis patients Kidney Int 66,841-848頁 (共著)
124.	2004	論文	Kinetic studies of covalent binding between N-acetyl-L-cysteine and human serum albumin through a mixed-disulfide using an N-methylpyridinium polymer-based column Drug Metab. Pharmacokinet. 19,297-302頁 (共著)
125.	2004	論文	Physicochemical characterization of cross-linked human serum albumin dimer and its synthetic heme hybrid as an oxygen carrier Biochim Biophys Acta 1675,21-31頁 (共著)
126.	2004	論文	Stabilizing mechanisms in commercial albumin preparations: octanoate and N-acetyl-L-tryptophanate protect human serum albumin against heat and oxidative stress Biochim Biophys Acta 1702,9-17頁 (共著)
127.	2004	論文	構造特性からみたアルブミン─薬物結合サイトと治療設計臨床検査 Vol.48,521-527頁 (共著)
128.	2003	論文	Validation of the chloramine-T induced oxidation of human serum albumin as a model for oxidative damage in vivo Pharm. Res 20,684-692頁 (共著)
129.	2001	論文	Effect of oxidative stress on the structure and function of human serum albumin Pharm. Res 18,632-639頁 (共著)
130.	2000	論文	Physicochemical characterization of a new crystal form and improvements in the pharmaceutical properties of the poorly water-soluble anti- osteoporosis drug 3,9-bis (N,N-dimethylcarbamoy-loxy)- 5H-benzofuro [3,2-c] quinoline-6-one (KCA-098) by solid dispersion with hydroxypropylcellulose Pharm. Dev. Technol 5,443-454頁 (共著)
131.	1999	論文	Inhibition of rabbit heart carbonyl reductase by fatty acids Biol. Pharm. Bull 22,731-733頁 (共著)