教員情報 - 國安　明彦

クニヤス　アキヒコ Kuniyasu Akihiko
國安　明彦

所属薬学部薬学科

職種教授

著書・論文歴
1.	1990	論文	拡張型心筋症の分子生物学的解析: 筋小胞体カルシウムチャンネルの動態最新医学 45,1960-1965頁 (共著)
2.	1994	論文	ジヒドロピリジン系Ｃa拮抗薬とＬ型Ｃaチャンネル Pharma Medica 1,7-11頁 (共著)
3.	1996	論文	Identification of binding sites for calcium channel antagonists. Jpn. Heart J. 37,,643-650頁 (共著)
4.	1998	論文	Photochemical identification of transmembrane segment IVS6 as the binding region of semotiadil, a new modulator for the L-type voltage-dependent Ca2+ channel. J. Biol. Chem. 273,4635-4641頁 (共著)
5.	1998	論文	Ｃａチャンネルの分子構造と機能相関心臓 30,71-76頁 (共著)
6.	1999	論文	[³⁵S] S-[5-(4-benzoylphenyl) pentyl] glutathione: a versatile radioligand targeting GS-X pumps with the ability of photoaffinity labeling. Bioorg. Med. Chem. Lett. 9,2661-2666頁 (共著)
7.	1999	論文	A new scorpion toxin (BmK-PL) stimulates Ca²⁺-release channel activity of the skeletal-muscle ryanodine receptor by an indirect mechanism. Biochem. J. 339,343-350頁 (共著)
8.	1999	論文	光アフィニティラベル法によるカルシウム拮抗薬結合部位の同定 Clinical Calcium 9,99-103頁 (共著)
9.	2000	論文	Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme. Biochem. Biophys. Res. Commun. 277,417-422頁 (共著)
10.	2001	論文	Asymmetric arrangement of auxiliary subunits of skeletal muscle voltage-gated L-type Ca²⁺ channel. Biochem. Biophys. Res. Commun. 282,284-291頁 (共著)
11.	2001	論文	Co-induction of arginino- succinate synthetase, cationic amino acid transporter-2, and nitric oxide synthase in activated murine microglial cells. Brain Res. Mol. Brain Res. 90,165-173頁 (共著)
12.	2002	論文	Adipocytes recognize and degrade oxidized low density lipoprotein through CD36. Biochem. Biophys. Res. Commun. 295,319-323頁 (共著)
13.	2002	論文	Efficient identification of photolabelled amino acid residues by combining immunoaffinity purification with MS: revealing the semotiadil-binding site and its relevance to binding sites for myristates in domain III of human serum albumin Biochem. J. 363,223-232頁 (共著)
14.	2003	論文	Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. J. Atheroscler. Thromb. 10,1-6頁 (共著)
15.	2003	論文	CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. FEBS Lett. 537,85-90頁 (共著)
16.	2003	論文	Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase. Chem. Biol. Interact. 143-144,353-361頁 (共著)
17.	2003	論文	Molecular assembly and subcellular distribution of ATP-sensitive potassium channel proteins in rat hearts. FEBS Lett. 552,259-263頁 (共著)
18.	2003	論文	Photochemical identification of the binding region for (S)-semotiadil on sodium channels: comparison with that for (R)-semotiadil on skeletal muscle calcium channel. Heterocycles 59,613-622頁 (共著)
19.	2003	論文	光ラベル法による薬物標的の同定薬学雑誌 123,673-679頁 (単著)
20.	2003	論文	心筋ATP感受性K⁺チャネルの免疫化学的解析 Therapeutic Res. 24,242-244頁 (共著)
21.	2004	論文	Advanced glycation end products- modified proteins and oxidized LDL mediate down-regulation of leptin in mouse adipocytes via CD36. Biochem. Biophys. Res. Commun. 325,151-156頁 (共著)
22.	2005	論文	Characterization of benzodiazepine binding site on human a1-acid glycoprotein using flunitrazepam as a photolabeling agent. Biochim. Biophys. Acta 1725,385-393頁 (共著)
23.	2005	論文	Proteasomal degradation of Kir6.2 channel protein and its inhibition by a Na⁺ channel blocker aprindine. Biochem. Biophys. Res. Commun. 331,1001-1006頁 (共著)
24.	2005	論文	Stoichiometry and binding site analysis of ligand-human serum albumin complex by photoaffinity labeling and mass spectrometry. J. Mass Spectrom. Soc. Jpn. 53,18-24頁 (共著)
25.	2006	論文	Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries. Cancer Res. 66,34-40 (共著)
26.	2007	論文	A previously unrecognized protein-protein interaction between TWEAK and CD163: Potential biological implications. J. Immunol. 178,8183-8194頁 (共著)
27.	2008	論文	Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells. J. Biol. Chem. 283,11752-11762頁 (共著)
28.	2008	論文	Constitutive overexpression of P-glycoprotein, rather than breast cancer resistance protein or organic cation transporter 1, contributes to acquisition of imatinib-resistance in K562 cells. Pharm. Res. 25,827-835 (共著)
29.	2009	論文	A synthetic approach to develop peptide inhibitors selective for brain-type sodium channels on the basis of pompilidotoxin structure. Heterocycles 79,925-933 (共著)
30.	2009	論文	Linkage between phosphorylation of the origin recognition complex and its ATP-binding activity in Saccharomyces cerevisiae. J. Biol. Chem. 284,3396-3407 (共著)
31.	2009	論文	Marked induction of inducible nitric oxide synthase and tumor necrosis factor-α in rat CD40⁺ microglia by comparison to CD40 microglia. J. Neuroimmunol. 208,70-79 (共著)
32.	2009	論文	Oral administration of synthetic retinoid Am80(Tamibarotene) decreases brain β-amyloid peptides in APP23 mice. Biol. Pharm. Bull. 32,1307-1309 (共著)
33.	2009	論文	オートファジーを誘導するペプチドケミカルエンジニヤリング 54,819-824 (単著)
34.	2010	論文	Contribution of BCR-ABL-independent activation of ERK1/2 to acquired imatinib resistance in K562 chronic myeloid leukemia cells. Cancer Sci. 101,137-142 (共著)
35.	2010	論文	Interconversion between pure chemotactic ligands and chemoattractant/secretagogue ligands of neutrophil C5_a receptor by a single amino acid substitution. J. Leukoc. Biol. 87,965-975 (共著)
36.	2010	論文	Three-dimensional structure of α1-β complex in skeletal muscle dihydropyridine receptor by single particle electron microscopy. J. Electron Microsc. 59,215-226 (共著)
37.	2010/02	論文	Notch-1 fragment peptide induces autophagy and caspase-independent cell death in leukemia cell lines An AACR special conference series: Cell Death Mechanisms and Cancer Therapy,71 (共著)
38.	2010/10	論文	Cell-selective cell penetrating peptide as an intelligent molecular carrier BIT 1st Annual World Congress of NanoMedicine-2010 (共著)
39.	2010/11	論文	オートファジー誘導に基づく白血病治療薬の開発研究戦略・YAKU学─研究現場から臨床へ─
40.	2011	論文	Oxidized LDL and lysophosphatidylcholine stimulate plasminogen activator inhibitor-1 expression through reactive oxygen species generation and ERK1/2 activation in 3T3-L1 adipocytes. Biochim. Biophys. Acta 1811,153-162 (共著)
41.	2011	論文	Quantitative analysis of cysteine-34 on the aniti-oxidative properties of human serum albumin in hemodialysis patients J. Pharm. Sci. 100,3968-3976頁 (共著)
42.	2011	論文	Targeting neuropilin-1 in human leukemia and lymphoma. Blood 117,920-927 (共著)
43.	2011	その他	ペプチドミメティックスによる新規細胞選択的物質導入キャリアの創製薬学研究の進歩 28,21-24頁 (単著)
44.	2012	論文	Effects of C4_a on chemoattractant and secretagogue functions of the other anaphylatoxins via Gi protein-adenylyl cyclase inhibition pathway in mast cells. Int. Immunopharmacol. 12,158-68 (共著)
45.	2012	論文	Intracerebral microinjection of interleukin- 4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice . Neuroscience 207,243-260 (共著)
46.	2012/02	論文	A hybrid peptide-25mer induces a caspase-independent cell death in leukemic cell lines Cell Death in Cancer,21 (共著)
47.	2013	論文	Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69,45-48頁 (共著)
48.	2014	論文	Cooperative therapeutic action of retinoic Acid receptor and retinoid X receptor agonists in a mouse model of Alzheimer's disease. J. Alzheimers Dis. 42,587-605頁 (共著)
49.	2014/07	論文	Hybrid peptide tat-Ram13-induced necrosis-like cell death depends on expression of PTEN in human leukemia cell lines. Eur. J. Cancer 50,23-24頁 (共著)
50.	2015	論文	Targeting interleukin-11 receptor in leukemia and lymphoma: A functional ligand-directed study and hematopathology analysis of patient-derived specimens. Clin. Cancer Res. 21 (13),3041-3051頁 (共著)
51.	2016/11	論文	The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain. Glia 64 (11),1938-1961頁 (共著)
52.	2017	著書	Combination of Photoaffinity Label and Site-Directed Antibody for Target Proteins Photoaffinity Labeling for Structural Probing Within Protein,93-110頁 (共著)
53.	2018/05	論文	Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery. J Control Release 10 (277),23-34頁 (共著)
54.	2018/05	論文	The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype. BMC Cancer 18 (1),519 (共著)
55.	2018/05	論文	Therapeutic targeting of membrane-associated GRP78 in leukemia and lymphoma: preclinical efficacy in vitro and formal toxicity study of BMTP-78 in rodents and primates Pharmacogenomics J 22 (18),436-443頁 (共著)
56.	2021/11	論文	Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells. Histochem. Cell. Biol. 156,409-421頁 (共著)
57.	2021/09	論文	Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine J Control Release 10 (337),546-556頁 (共著)