Faculty Information - Imoto Shuhei

Imoto Shuhei

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2026	Papers	Mechanistic Insights into pH-Responsive Drug Release and Antitumor Effects of an Albumin-Pirarubicin Conjugate Pharmaceutical Research in press (Co-authored)
2.	2026	Papers	Secreted protein acidic and rich in cysteine-guided biomimetic delivery of nano-antioxidants reverses muscle atrophy in a mouse model of sarcopenia Journal of Controlled Release 391,pp.114567 (Co-authored)
3.	2025	Papers	Sequence-selective 2'-O-acetyl modification of RNA mediated by duplex formation with a reactive oligonucleotide probe incorporating 4-thio-dT Chem. Pharm. Bull. 73 (12),pp.1122-1125 (Co-authored)
4.	2025	Papers	Lymph node macrophage-targeted interferon alpha boosts anticancer immune responses by regulating CD169-positive phenotype of macrophages Molecular Cancer 24 (1),pp.132 (Co-authored)
5.	2024	Papers	Site-specific acetyl modification of 2'-OH of RNA by an oligonucleotide acetylating reagent Chem. Commun. 60,pp.13440-13442 (Co-authored)
6.	2024	Papers	Novel Diclofenac-NO Donor With High Affinity for Human Serum Albumin Induces Endoplasmic Reticulum Stress-mediated Cell Death in Human Pancreatic Cancer Cells Anticancer Research 44 (9),pp.3793-3798 (Co-authored)
7.	2024	Papers	Ibuprofen‑derived nitric oxide donors with a high affinity to human serum albumin induce cell death in pancreatic cancer cells through a non‑caspase 3/7‑mediated pathway Biomed Rep. 21 (5),pp.159 (Co-authored)
8.	2024	Papers	Regio- and Stereoselective Synthesis of 2'-Deoxy-4'-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and Cytotoxicity Leading to Improved Selectivity Index by 4'-C-Cyanation Synlett 35 (6),pp.728-733 (Co-authored)
9.	2024	Papers	Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin Chem. Pharm. Bull. 72 (1),pp.21-27 (Co-authored)
10.	2023	Papers	Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis ACS Nano 17,pp.16668-16681 (Co-authored)
11.	2023	Papers	Water-dispersible carbon nano-test tubes as a container for DNA molecules Chem. Eur. J. e202301422 (Co-authored)
12.	2023	Papers	Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and longacting anti-hepatitis B virus agent RSC Adv. 13,pp.15999-16011 (Co-authored)
13.	2023	Papers	A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes Virus Research 329,pp.199094 (Co-authored)
14.	2022	Papers	Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts Oncology Reports 48 (4),pp.178 (Co-authored)
15.	2022	Papers	Chlorine Atoms of an Aripiprazole Molecule Control the Geometry and Motion of Aripiprazole and Deschloro-aripiprazole in Subdomain IIIA of Human Serum Albumin ACS omega 7 (34),pp.29944-29951 (Co-authored)
16.	2022	Papers	Trimethoxy trityl groups as a potent substituent for anti-cancer cytidine analog prodrugs Journal of Pharmaceutical Sciences 111 (8),pp.2201-2209 (Co-authored)
17.	2022	Papers	The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism Anticancer Res. 42 (3),pp.1333-1338 (Co-authored)
18.	2021	Papers	Pharmacokinetics of 4'-cyano-2'-deoxyguanosine, a novel nucleoside analog inhibitor of the resistant hepatitis B virus, in a rat model of chronic kidney disease Journal of Infection and Chemotherapy 27 (5),pp.702-706 (Co-authored)
19.	2021	Papers	Synthesis and in vitro assessment of pH-sensitive human serum albumin conjugates of pirarubicin Pharmaceuticals 14 (1),pp.22 (Co-authored)
20.	2020	Papers	Design and Synthesis of 4'-Cyano Dideoxy Isonucleosides and Their Activity against HIV-1 and HBV Heterocycles 100 (10),pp.1599-1612 (Co-authored)
21.	2020	Papers	Pharmacokinetic Properties of Orally Administered 4'-Cyano-2'-deoxyguanosine, a Novel Nucleoside Analog Inhibitor of the Hepatitis B Virus, in Viral Liver Injury Model Rats Biol. Pharm. Bull. 43,pp.1426-1429 (Co-authored)
22.	2020	Papers	Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent Nucleosides, Nucleotides and Nucleic Acids 39 (4),pp.518-529 (Co-authored)
23.	2020	Papers	Cell uptake and anti-tumor effect of liposomes containing encapsulated paclitaxel-bound albumin against breast cancer cells in 2D and 3D cultured models Journal of Drug Delivery Science and Technology 55,pp.101381 (Co-authored)
24.	2019	Papers	Interaction of Aripiprazole with Human α₁-Acid Glycoprotein Journal of Pharmaceutical Sciences 108 (12),pp.3911-3916 (Co-authored)
25.	2019	Papers	The preparation, characterization and in vitro/in vivo evaluation of paclitaxel-bound albumin encapsulated liposomes for the treatment of pancreatic cancer ACS Omega 4 (5),pp.8693-8700 (Co-authored)
26.	2019	Papers	CMCdG, a novel nucleoside analog, exerts potent activity against wild-type and entecavir-resistant HBV with favorable safety feature Antimicrobial Agents and Chemotherapy 64 (4),pp.e02143-18 (Co-authored)
27.	2018	Papers	Synthesis, Anti-HBV and Anti-HIV Activities of 3'-Halogenated bis(hydroxymethyl)-cyclopentenyladenines (BCAs) ACS Medicinal Chemistry Letters 9 (12),pp.1211-1216 (Co-authored)
28.	2018	Papers	Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure ACS Omega 3 (10),pp.13790-13797 (Co-authored)
29.	2018	Papers	In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers Journal of Drug Delivery Science and Technology 47,pp.62-66 (Co-authored)
30.	2018	Papers	Pharmacokinetic properties of a novel inosine analog, 4'-cyano-2'-deoxyinosine, after oral administration in rats PLOS ONE 13 (6),pp.e0198636 (Co-authored)
31.	2018	Papers	Synthesis of 4'-Substituted Purine 2'-Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus ChemistrySelect 3 (11),pp.3313-3317 (Co-authored)
32.	2018	Papers	Pharmacokinetics studies of 4'-cyano-2'-deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats Journal of Pharmacy and Pharmacology 70 (6),pp.723-731 (Co-authored)
33.	2017	Papers	A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity Nucleosides, Nucleotides and Nucleic Acids 36 (7),pp.463-473 (Co-authored)
34.	2017	Papers	Synthesis of native-like crosslinked duplex RNA and study of its properties Bioorg. Med. Chem. 25 (7),pp.2191-2199 (Co-authored)
35.	2016	Papers	Diastereoselective Synthesis of 6"-(Z)- and 6"-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers J. Org. Chem. 81 (7),pp.2827-2836 (Co-authored)
36.	2015	Papers	Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives Nucleosides, Nucleotides and Nucleic Acids 34 (8),pp.590-602 (Co-authored)
37.	2013	Papers	The Crosslink Formation of 2'-OMe Oligonucleotide Containing 2-amino-6-vinylpurine Protects mRNA from miRNA-mediated Silencing ChemBioChem 14,pp.1427-1429 (Co-authored)
38.	2013	Papers	Human DNA Polymerase β, but Not λ, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen. ACS Chem. Biol. 8,pp.336-344 (Co-authored)
39.	2012	Papers	Production of truncated protein by a crosslink formation of mRNA with 2'-OMe oligoribonucleotide containing 2-amino-6-vinylpurine Bioorg. Med. Chem. Lett. 22,pp.3870-3872 (Co-authored)
40.	2012	Papers	Fast DNA Interstrand Cross-linking Reaction by 6-Vinylpurine Nucleosides, Nucleotides and Nucleic Acids 31 (10),pp.752-762 (Co-authored)
41.	2011	Papers	Induced Cross-linking Reactions to Target Genes Using Modified Oligonucleotides. Organic & Biomolecular Chemistry 9,pp.2579-2585 (Co-authored)
42.	2010	Papers	Altertion of Cross-linking Selectivity with the 2'-OMe Analogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense effects. Bioorg. Med. Chem. Lett. 20,pp.6121-6124 (Co-authored)
43.	2009	Papers	The Mutagenicity of Thymidine Glycol in Escherichia coli Is Increased When It Is Part of a Tandem Lesion. Biochemistry 48,pp.7833-7841 (Co-authored)
44.	2009	Papers	Incorporation of an Inducible Nucleotide Analog into DNA by DNA Polymerases. Bioorg. Med. Chem. 17,pp.2859-2863 (Co-authored)
45.	2009	Papers	Highly Selective and Efficient Interstrand Cross-Linking Formation to Thymine Without Photo-Irradiation. Chem. Comm. 42,pp.6463-6465 (Co-authored)
46.	2009	Papers	Design and Synthesis of the Novel Cross-Linking Agent. Nucleic Acids Symp. Ser. 53,pp.169-170 (Co-authored)
47.	2008	Papers	Synthesis of the Peptide Nucleic Acid (PNA) Incorporating 2-Amino-6-vinylpurine Derivative and Evaluation of the Reactivity Nucleic Acids Symp. Ser. 52,pp.391-392 (Co-authored)
48.	2008	Papers	Stereoselective Synthesis of (+)-2-Deoxyolivin Based on Cycloaddition Reaction between the Homophthalic Anhydride and the Chiral Cyclohexenone Derivative. Tetrahedron 64,pp.7211-7218 (Co-authored)
49.	2008	Papers	New Methodology to Search for DNA Binding Ligands Based on Duplex DNA-Templated Click Chemistry. Nucleic Acids Symp. Ser. 52,pp.381-382 (Co-authored)
50.	2008	Papers	DNA Templated Click Chemistry for Creation of Novel DNA Binding Molecules. Bioorg. Med. Chem. Lett. 18,pp.5660-5663 (Co-authored)
51.	2008	Papers	DNA Tandem Lesion Repair by Strand Displacement Synthesis and Nucleotide Excision Repair. Biochemistry 47,pp.4306-4316 (Co-authored)
52.	2007	Papers	Synthesis of 6-Substituted Purine Derivatives Using Pd-Catalyzed Cross-Coupling Reactions with 2'-Deoxyguanosine O⁶-Tosylate. Heterocycles 73,pp.493-501 (Co-authored)
53.	2007	Papers	Enzymatic Incorporation of 2-Amino-6-vinyl Purine Derivative. Nucleic Acids Symp. Ser. 51,pp.357-358 (Co-authored)
54.	2006	Papers	Synthesis, DNA Polymease Incorporation, and Enzymatic Phosphate Hydolysis of Formamide Nucleotide Triphosphates. J. Am. Chem. Soc. 128,pp.14606-14611 (Co-authored)
55.	2004	Papers	New DNA Binding Ligands as a Model of Chromomycin A₃ Bioorg. Med. Chem. Lett. 14,pp.4855-4859 (Co-authored)