教員情報 - 井本　修平

イモト　シュウヘイ Imoto Shuhei
井本　修平

所属薬学部薬学科

職種教授

著書・論文歴
1.	2024	論文	Regio- and Stereoselective Synthesis of 2'-Deoxy-4'-thioguanine Nucleosides: Evaluation of Anti-Hepatitis B Virus Activity and Cytotoxicity Leading to Improved Selectivity Index by 4'-C-Cyanation Synlett 35 (6),728-733頁 (共著)
2.	2024	論文	Preparation and in Vitro Characterization of Fatty-Acid Modified Pirarubicin Nanosuspensions Stabilized by Albumin Chem. Pharm. Bull. 72 (1),21-27頁 (共著)
3.	2023	論文	Encapsulation of an Antioxidant in Redox-Sensitive Self-Assembled Albumin Nanoparticles for the Treatment of Hepatitis ACS Nano 17,16668-16681頁 (共著)
4.	2023	論文	Water-dispersible carbon nano-test tubes as a container for DNA molecules Chem. Eur. J. e202301422 (共著)
5.	2023	論文	Synthesis of novel entecavir analogues having 4'-cyano-6''-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and longacting anti-hepatitis B virus agent RSC Adv. 13,15999-16011頁 (共著)
6.	2023	論文	A Novel Anti-HBV Agent, E-CFCP, restores Hepatitis B virus (HBV)-induced Senescence-associated Cellular Markers Perturbation in Human Hepatocytes Virus Research 329,199094 (共著)
7.	2022	論文	Novel nitric oxide donor, nitrated phenylbutyrate, induces cell death of human pancreatic cancer cells and suppresses tumor growth of cancer xenografts Oncology Reports 48 (4),178 (共著)
8.	2022	論文	Chlorine Atoms of an Aripiprazole Molecule Control the Geometry and Motion of Aripiprazole and Deschloro-aripiprazole in Subdomain IIIA of Human Serum Albumin ACS omega 7 (34),29944-29951頁 (共著)
9.	2022	論文	Trimethoxy trityl groups as a potent substituent for anti-cancer cytidine analog prodrugs Journal of Pharmaceutical Sciences 111 (8),2201-2209頁 (共著)
10.	2022	論文	The Nitrated Form of Nateglinide Induces Apoptosis in Human Pancreatic Cancer Cells Through a Caspase-dependent Mechanism Anticancer Res. 42 (3),1333-1338頁 (共著)
11.	2022	論文	令和2年度ベストティーチング賞受賞教員の授業について―更なる授業改善を目指して(第5報)― 崇城大学紀要 47,97-111頁 (共著)
12.	2021	論文	Pharmacokinetics of 4'-cyano-2'-deoxyguanosine, a novel nucleoside analog inhibitor of the resistant hepatitis B virus, in a rat model of chronic kidney disease Journal of Infection and Chemotherapy 27 (5),702-706頁 (共著)
13.	2021	論文	Synthesis and in vitro assessment of pH-sensitive human serum albumin conjugates of pirarubicin Pharmaceuticals 14 (1),22 (共著)
14.	2020	論文	Design and Synthesis of 4'-Cyano Dideoxy Isonucleosides and Their Activity against HIV-1 and HBV Heterocycles 100 (10),1599-1612頁 (共著)
15.	2020	論文	Pharmacokinetic Properties of Orally Administered 4'-Cyano-2'-deoxyguanosine, a Novel Nucleoside Analog Inhibitor of the Hepatitis B Virus, in Viral Liver Injury Model Rats Biol. Pharm. Bull. 43,1426-1429頁 (共著)
16.	2020	論文	Synthesis and evaluation of the anti-hepatitis B virus activity of 4'-Azido-thymidine analogs and 4'-Azido-2'-deoxy-5-methylcytidine analogs: structural insights for the development of a novel anti-HBV agent Nucleosides, Nucleotides and Nucleic Acids 39 (4),518-529頁 (共著)
17.	2020	論文	Cell uptake and anti-tumor effect of liposomes containing encapsulated paclitaxel-bound albumin against breast cancer cells in 2D and 3D cultured models Journal of Drug Delivery Science and Technology 55,101381 (共著)
18.	2019	論文	Interaction of Aripiprazole with Human α₁-Acid Glycoprotein Journal of Pharmaceutical Sciences 108 (12),3911-3916頁 (共著)
19.	2019	論文	The preparation, characterization and in vitro/in vivo evaluation of paclitaxel-bound albumin encapsulated liposomes for the treatment of pancreatic cancer ACS Omega 4 (5),8693-8700頁 (共著)
20.	2019	論文	CMCdG, a novel nucleoside analog, exerts potent activity against wild-type and entecavir-resistant HBV with favorable safety feature Antimicrobial Agents and Chemotherapy 64 (4),e02143-18 (共著)
21.	2019	論文	Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin Journal of Pharmaceutical Sciences 108 (5),1890-1895頁 (共著)
22.	2018	論文	Synthesis, Anti-HBV and Anti-HIV Activities of 3'-Halogenated bis(hydroxymethyl)-cyclopentenyladenines (BCAs) ACS Medicinal Chemistry Letters 9 (12),1211-1216頁 (共著)
23.	2018	論文	Analysis of the Binding of Aripiprazole to Human Serum Albumin: The Importance of a Chloro-Group in the Chemical Structure ACS Omega 3 (10),13790-13797頁 (共著)
24.	2018	論文	In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers Journal of Drug Delivery Science and Technology 47,62-66頁 (共著)
25.	2018	論文	Pharmacokinetic properties of a novel inosine analog, 4'-cyano-2'-deoxyinosine, after oral administration in rats PLOS ONE 13 (6),e0198636 (共著)
26.	2018	論文	Synthesis of 4'-Substituted Purine 2'-Deoxynucleosides and Their Activity against Human Immunodeficiency Virus Type 1 and Hepatitis B Virus ChemistrySelect 3 (11),3313-3317頁 (共著)
27.	2018	論文	Pharmacokinetics studies of 4'-cyano-2'-deoxyguanosine, a potent inhibitor of the hepatitis B virus, in rats Journal of Pharmacy and Pharmacology 70 (6),723-731頁 (共著)
28.	2017	論文	A novel entecavir analogue constructing with a spiro[2.4]heptane core structure in the aglycon moiety: Its synthesis and evaluation for anti-hepatitis B virus activity Nucleosides, Nucleotides and Nucleic Acids 36 (7),463-473頁 (共著)
29.	2017	論文	Synthesis of native-like crosslinked duplex RNA and study of its properties Bioorg. Med. Chem. 25 (7),2191-2199頁 (共著)
30.	2016	論文	Diastereoselective Synthesis of 6"-(Z)- and 6"-(E)-Fluoro Analogues of Anti-hepatitis B Virus Agent Entecavir and Its Evaluation of the Activity and Toxicity Profile of the Diastereomers J. Org. Chem. 81 (7),2827-2836頁 (共著)
31.	2015	論文	Design, Synthesis, and Evaluation of Anti-HBV Activity of Hybrid Molecules of Entecavir and Adefovir: Exomethylene Acycloguanine Nucleosides and Their Monophosphate Derivatives Nucleosides, Nucleotides and Nucleic Acids 34 (8),590-602頁 (共著)
32.	2013	論文	The Crosslink Formation of 2'-OMe Oligonucleotide Containing 2-amino-6-vinylpurine Protects mRNA from miRNA-mediated Silencing ChemBioChem 14,1427-1429頁 (共著)
33.	2013	論文	Human DNA Polymerase β, but Not λ, Can Bypass a 2-Deoxyribonolactone Lesion Together with Proliferating Cell Nuclear Antigen. ACS Chem. Biol. 8,336-344頁 (共著)
34.	2012	論文	Production of truncated protein by a crosslink formation of mRNA with 2'-OMe oligoribonucleotide containing 2-amino-6-vinylpurine Bioorg. Med. Chem. Lett. 22,3870-3872頁 (共著)
35.	2012	論文	Fast DNA Interstrand Cross-linking Reaction by 6-Vinylpurine Nucleosides, Nucleotides and Nucleic Acids 31 (10),752-762頁 (共著)
36.	2012	論文	金触媒N-グリコシル化による温和なヌクレオシド合成ファルマシア 48 (1),55 (単著)
37.	2011	論文	Induced Cross-linking Reactions to Target Genes Using Modified Oligonucleotides. Organic & Biomolecular Chemistry 9,2579-2585頁 (共著)
38.	2010	論文	Altertion of Cross-linking Selectivity with the 2'-OMe Analogue of 2-Amino-6-Vinylpurine and Evaluation of Antisense effects. Bioorg. Med. Chem. Lett. 20,6121-6124頁 (共著)
39.	2009	論文	The Mutagenicity of Thymidine Glycol in Escherichia coli Is Increased When It Is Part of a Tandem Lesion. Biochemistry 48,7833-7841頁 (共著)
40.	2009	論文	Incorporation of an Inducible Nucleotide Analog into DNA by DNA Polymerases. Bioorg. Med. Chem. 17,2859-2863頁 (共著)
41.	2009	論文	Highly Selective and Efficient Interstrand Cross-Linking Formation to Thymine Without Photo-Irradiation. Chem. Comm. 42,6463-6465頁 (共著)
42.	2009	論文	Design and Synthesis of the Novel Cross-Linking Agent. Nucleic Acids Symp. Ser. 53,169-170頁 (共著)
43.	2008	論文	Synthesis of the Peptide Nucleic Acid (PNA) Incorporating 2-Amino-6-vinylpurine Derivative and Evaluation of the Reactivity Nucleic Acids Symp. Ser. 52,391-392頁 (共著)
44.	2008	論文	Stereoselective Synthesis of (+)-2-Deoxyolivin Based on Cycloaddition Reaction between the Homophthalic Anhydride and the Chiral Cyclohexenone Derivative. Tetrahedron 64,7211-7218頁 (共著)
45.	2008	論文	New Methodology to Search for DNA Binding Ligands Based on Duplex DNA-Templated Click Chemistry. Nucleic Acids Symp. Ser. 52,381-382頁 (共著)
46.	2008	論文	DNA Templated Click Chemistry for Creation of Novel DNA Binding Molecules. Bioorg. Med. Chem. Lett. 18,5660-5663頁 (共著)
47.	2008	論文	DNA Tandem Lesion Repair by Strand Displacement Synthesis and Nucleotide Excision Repair. Biochemistry 47,4306-4316頁 (共著)
48.	2007	論文	Synthesis of 6-Substituted Purine Derivatives Using Pd-Catalyzed Cross-Coupling Reactions with 2'-Deoxyguanosine O⁶-Tosylate. Heterocycles 73,493-501頁 (共著)
49.	2007	論文	Enzymatic Incorporation of 2-Amino-6-vinyl Purine Derivative. Nucleic Acids Symp. Ser. 51,357-358頁 (共著)
50.	2006	論文	Synthesis, DNA Polymease Incorporation, and Enzymatic Phosphate Hydolysis of Formamide Nucleotide Triphosphates. J. Am. Chem. Soc. 128,14606-14611頁 (共著)
51.	2004	論文	New DNA Binding Ligands as a Model of Chromomycin A₃ Bioorg. Med. Chem. Lett. 14,4855-4859頁 (共著)
52.	2004	論文	横幅の広がった天然よりも安定な二重らせんDNA 化学と工業 57 (7),764 (単著)