SOJO UNIVERSITY
Research Achievements Database
Japanese
Nakamura Hitomi
Department / Course
FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences
Job
Book and thesis
1.
2024
Papers
Stabilization of adalimumab Fab through the introduction of disulfide bonds between the variable and constant domains. Biochem. Biophys. Res. Commun. 700,pp.149592 (Co-authored)
2.
2023
Papers
Enhancing thermal stability in the CH
2
domain to suppress aggregation through the introduction of simultaneous disulfide bonds in
Pichia pastoris
. Protein Sci. 32 (12),pp.e4831 (Co-authored)
3.
2023
Papers
Analysis of thermostability for seven Phe to Ala and six Pro to Gly mutants in the Fab constant region of adalimumab. J. Biochem. 174 (4),pp.345-353 (Co-authored)
4.
2022
Papers
Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity. J. Biochem. 172 (1),pp.49-56 (Co-authored)
5.
2021
Papers
A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab. Sci. Rep. 11 (1),pp.12937 (Co-authored)
6.
2021
Papers
Glycosylation decreases aggregation and immunogenicity of adalimumab Fab secreted from
Pichia pastoris
. J. Biochem. 169 (4),pp.435-443 (Co-authored)
7.
2020
Papers
C-terminal cysteine PEGylation of adalimumab Fab with an engineered interchain SS bond. Biol. Pharm. Bull. 43 (3),pp.418-423 (Co-authored)
8.
2019
Papers
Alternative mRNA Splicing in Three Venom Families Underlying a Possible Production of Divergent Venom Proteins of the Habu Snake,
Protobothrops flavoviridis
. Toxins (Basel) (Co-authored)
9.
2018
Papers
The habu genome reveals accelerated evolution of venom protein genes. Sci Rep. 8 (1) (Co-authored)
10.
2018
Papers
Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab. Biochem. Biophys. Res. Commun. 503 (2),pp.752-756 (Co-authored)
11.
2017
Papers
A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab. Biochem. Biophys. Res. Commun. 495 (1),pp.7-11 (Co-authored)
12.
2016
Papers
Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2. Biochim Biophys Acta. 1860 (10),pp.2279-2284 (Co-authored)
13.
2014
Papers
Epithelium specific ETS transcription factor, ESE-3, of
Protobothrops flavoviridis
snake venom gland transactivates the promoters of venom phospholipase A
2
isozyme genes. Toxicon 92,pp.133-139 (Co-authored)
14.
2014
Papers
Discovery of a novel vascular endothelial growth factor (VEGF) with no affinity to heparin in
Gloydius tsushimaensis
venom. Toxicon 86,pp.107-115 (Co-authored)
15.
2011
Papers
A [Lys
49
] phospholipase A
2
from
Protobothrops flavoviridis
venom induces caspase-independent apoptotic cell death accompanied by rapid plasma-membrane rupture in human leukemia cells. Biosci. Biotechnol. Biochem. 75,pp.864-870 (Co-authored)