教員情報 - 方　軍

ファン　ジュン Fang Jun
方　軍

所属薬学部薬学科

職種准教授

著書・論文歴
1.	1998	論文	Expression of standard and variant CD44 in human lung cancer Zhonghua Jie He He Hu Xi Za Zhi 21 (９),541-543頁 (共著)
2.	1999	論文	Circumferential resection and "Z"-shape plastic end-to-end anastomosis of canine trachea Chin Med J (Engl) 112 (3),278-280頁 (共著)
3.	2002	論文	Pegylated zinc portoporphyrin: a water-soluble heme oxygenase inhibitor with tumor-targeting capacity Bioconjug Chem 13 (5),1031-1038頁 (共著)
4.	2002	論文	Tumor-targeted Delivery of Polyethylene Glycol-conjugated D-Amino Acid Oxidase for Antitumor Therapy via Enzymatic Generation of Hydrogen Peroxide Cancer Res 62 (11),3138-3143頁 (共著)
5.	2003	論文	Antiapoptotic effect of haem oxygenase-1 induced by nitric oxide in experimental solid tumour Br J Cancer 88,902-909頁 (共著)
6.	2003	論文	Factors and mechanism of EPR effect and the enhanced antitumor effects of macromolecular drugs including SAMNCS Adv Exp Med Biol 519,29-49頁 (共著)
7.	2003	論文	In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor Cancer Res 63 (13),3567-3574頁 (共著)
8.	2003	論文	Macromolecular anticancer therapeutics for effective solid tumor targeting: advantages and prospects Clin. Pharmacokinet 42 (13),1089-1115頁 (共著)
9.	2003	論文	Modulation of tumor-selective vascular blood flow and extravasation by the stable prostaglandin I2 analogue beraprost sodium J Drug Target 11 (1),45-52頁 (共著)
10.	2003	論文	Vascular permeability enhancement in solid tumor: various factors, mechanisms and implication Int Immunopharm 3 (3),319-328頁 (共著)
11.	2004	論文	Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment Apoptosis 9 (1),27-35頁 (共著)
12.	2004	論文	Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin Int J Cancer 109 (1),1-8頁 (共著)
13.	2004	論文	SMA-doxorubicin, a new polymeric micellar drug for effective targeting to solid tumours J Control Release 97 (2),219-230頁 (共著)
14.	2005	論文	An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface J Biol Chem 280,1740-1745頁 (共著)
15.	2005	論文	Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity Bioconjug Chem 16 (1),230-236頁 (共著)
16.	2005	著書	Factors and mechanism of EPR effect and clinical outlook of SMANCS Cancer Chemoprevention and Drug Therapy of the New Millenium,197-212頁 (共著)
17.	2005/10	論文	癌・炎症と物質動態：高分子薬剤のEPR効果と癌治療を中心に 21 (12),49-58頁 (共著)
18.	2006	著書	Enhanced permeability and retention (EPR) effect and tumor-selective delivery of anticancer drugs Delivery of Protein and Peptide Drugs in Cancer,37-52頁 (共著)
19.	2006	論文	EPR effect and polymeric drugs: challenge for a paradigm shift for cancer chemotherapy in the 21st century Adv Polym Sci 193,103-121頁 (共著)
20.	2006	論文	Exploiting the enhanced permeability and retention effect for tumor targeting Drug Discov Today 11 (17-18),812-818頁 (共著)
21.	2006	論文	The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma Mol Pharmacol 70 (6),2108-2115頁 (共著)
22.	2007	論文	High-loading nanosized micelles of copoly(styrene-maleic acid)-zinc protoporphyrin for targeted delivery of a potent heme oxygenase inhibitor Biomaterials 28 (10),1871-1881頁 (共著)
23.	2007	論文	Tumor-targeted induction of oxystress for cancer therapy J Drug Target 15 (7),475-486頁 (共著)
24.	2008	論文	Implication of heme oxygenase-1 in the sensitivity of nasopharyngeal carcinomas to radiotherapy J Exp Clin Cancer Res 27,13 (共著)
25.	2008	論文	Oxystress inducing antitumor therapeutics via targeted delivery of PEG-conjugated D-amino acid oxidase Int J Cancer 122 (5),1135-1144頁 (共著)
26.	2009	論文	Enhanced delivery of macromolecular antitumor drugs to tumors by nitroglycerin application Cancer Sci 100 (12),2426-2430頁 (共著)
27.	2009	論文	Generation of drug-resistant mutants of Helicobacer pylori in the presence of peroxynitrite, a derivative of nitric oxide, at pathophysiological concentration Microbiol Immunol 53 (1),1-7頁 (共著)
28.	2009	論文	Pretreatment with glutamine attenuates anoxia/reoxygenation injury of human proximal renal tubular epithelial cells via induction of heme oxygenase-1 Pharmacology 84 (1),1-8頁 (共著)
29.	2009	論文	SMA-copolymer conjugate of AHPP: a polymeric inhibitor of xanthine oxidase with potential antihypertensive effect J Control Release 135 (3),211-217頁 (共著)
30.	2009	論文	Therapeutic strategies by modulating oxygen stress in cancer and inflammation Adv Drug Deliv Rev 61 (4),290-302頁 (共著)
31.	2009	著書	Tumor targeted macromolecular drug delivery based on the enhanced permeability and retention effects in solid tumor Pharmacrutical Perspective of Cancers Therapeutics,93-102頁 (共著)
32.	2010	論文	Tissue protective effect of xanthine oxidase inhibitor, polymer conjugate of (styrene-maleic acid copolymer) and (4-amino-6-hydroxypyrazolo[3,4-d]pyrimidine), on hepatic ischemia-reperfusion injury Exp Biol Med (Maywood) 235 (4),487-496頁 (共著)
33.	2011	論文	4-Amino-6-hydroxypyrazolo [3,4-d]pyrimidine (AHPP) conjugated PEG micelles: Water soluble polymeric xanthine oxidase inhibitor J Drug Target 19 (10),954-966頁 (共著)
34.	2011	論文	Intracellular uptake and behavior of two types zinc protoporphyrin (ZnPP) micelles, SMA-ZnPP and PEG-ZnPP as anticancer agents; Unique intracellular disintegration of SMA micelles J Control Release 155 (3),367-375頁 (共著)
35.	2011	論文	The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect Adv Drug Deliv Rev 63,136-151頁 (共著)
36.	2011	論文	Therapeutic potential of pegylated hemin for ROS-related diseases via induction of heme oxygenase-1: results from a rat hepatic ischemia/reperfusion injury model J Pharmacol Exp Ther 339 (3),779-789頁 (共著)
37.	2012	論文	Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention (EPR) effect of solid tumor Cancer Sci 103 (3),535-541頁 (共著)
38.	2012	論文	HSP32 (HO-1) inhibitor, copoly(styrene maleic acid)-zinc protoporphyrin IX, a water soluble micelle as anticancer agent: in vitro and in vivo anticancer effect Eur J Pharm. Biopharm 81 (3),540-547頁 (共著)
39.	2012	論文	PEGylated D-amino acid oxidase restores bactericidal activity of neutrophils in chronic granulomatous disease via hypochlorite Exp Biol Med (Maywood) 237 (6),703-708頁 (共著)
40.	2012	著書	PEGylated zinc protoporphyrin: a micelle forming polymeric drug for cancer therapy Nanotechnology in Health Care,169-191頁 (共著)
41.	2012	論文	Protective Role of D-Amino Acid Oxidase Against Staphylococcus aureus infection Infect Immun 80 (4),1546-1553頁 (共著)
42.	2012	論文	S-Nitrosated Human Serum Albumin Dimer is not only a Novel Anti-Tumor Drug but also a Potentiator for Anti-Tumor Drugs with Augmented EPR Effects Bioconjug Chem 23 (2),264-271頁 (共著)
43.	2012	論文	Styrene-co-maleic Acid (SMA) Telomeric Micelles Encapsulated-Zinc Protoporphyrin (SMA-ZnPP) and Other Drugs: Stability Study CRS Newsletter 29,6-7頁 (共著)
44.	2013	論文	Micelles of zinc protoporphyrin conjugated to N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer for imaging and light-induced antitumor effects in vivo J Control Release 165 (3),191-198頁 (共著)
45.	2013	論文	Protection from inflammatory bowel disease and colitis-associated carcinogenesis with 4-vinyl-2,6-dimethoxyphenol (canolol) involve suppression of oxidative stress and inflammatory cytokines Carcinogenesis 34 (12),2833-2841頁 (共著)
46.	2013	論文	The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo Adv Drug Deliv Rev 65 (1),71-79頁 (共著)
47.	2013	論文	Tissue-Protective Effect of Glutamine on Hepatic Ischemia-Reperfusion Injury via Induction of Heme Oxygenase-1 Pharmacology 91 (1-2),59-68頁 (共著)
48.	2014	論文	Bufalin loaded biotinylated chitosan nanoparticles: An efficient drug delivery system for targeted chemotherapy against breast carcinoma. Eur J Pharm Biopharm. 87 (3),445-453頁 (共著)
49.	2014	論文	Styrene-maleic acid copolymer-encapsulated CORM2, a water-soluble carbon monoxide (CO) donor with a constant CO-releasing property, exhibits therapeutic potential for inflammatory bowel disease. J Control Release 187,14-21頁 (共著)
50.	2014	論文	Enhanced Bacterial Tumor Delivery by Modulating the EPR Effect and Therapeutic Potential of Lactobacillus casei J Pharm Sci. 103 (10),3235-3243頁 (共著)
51.	2014	論文	Tuning of poly-s-nitrosated human serum albumin as superior antitumor nanomedicine. J Pharm Sci. 1037 (7),2184-2188頁 (共著)
52.	2014	論文	Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage J Control Release 174C,81-87頁 (共著)
53.	2014	論文	Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. BMC Cancer 14 (1),436 (共著)
54.	2015	論文	Comparison between linear and star-like HPMA conjugated pirarubicin (THP) in pharmacokinetics and antitumor activity in tumor bearing mice Eur J Pharm Biopharm. 90,90-96頁 (共著)
55.	2015	論文	Effect of different chemical bonds in pegylation of zinc protoporphyrin that affects drug release, intracellular uptake, and therapeutic effect in the tumor Eur J Pharm Biopharm. 89,259-270頁 (共著)
56.	2015	論文	Enhanced permeability and retention effect based nanomedicine, a solution for cancer World J Pharmcology 4 (2),168-171頁 (単著)
57.	2015	論文	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases Target Oncol. (共著)
58.	2015	論文	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin Future Sci. OA,FSO4 (共著)
59.	2015	論文	Poly-S-nitrosated human albumin enhances the antitumor and antimetastasis effect of bevacizumab, partly by inhibiting autophagy via the generation of nitric oxide. Cancer Sci. 106 (2),194-200頁 (共著)
60.	2015	論文	S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes J Control Release 217,1-9頁 (共著)
61.	2015	論文	Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer Oncotarget. 6 (19),17391-17403頁 (共著)
62.	2015	論文	Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging J Drug Target. (共著)
63.	2015	論文	Synthesis and therapeutic effect of styrene-maleic acid copolymer conjugated pirarubicin. Cancer Sci. 106 (3),270-278頁 (共著)
64.	2015/11	論文	Photodynamic therapy and imaging based on tumor-targeted nanoprobe, polymer-conjugated zinc protoporphyrin. Future Sci. OA. (共著)
65.	2015/12	論文	pH sensitive polymeric complex of cisplatin with hyaluronic acid exhibits tumor-targeted delivery and improved in vivo antitumor effect. Int J Pharm. (共著)
66.	2016	論文	Enhancement of Tumor-Targeted Delivery of Bacteria with Nitroglycerin Involving Augmentation of the EPR Effect. Methods Mol Biol. (共著)
67.	2016/02	論文	HPMA Copolymer-Conjugated Pirarubicin in Multimodal Treatment of a Patient with Stage IV Prostate Cancer and Extensive Lung and Bone Metastases. (共著)
68.	2016/02	論文	pH-sensitive polymeric cisplatin-ion complex with styrene-maleic acid copolymer exhibits tumor-selective drug delivery and antitumor activity as a result of the enhanced permeability and retention effect. Colloids Surf B Biointerfaces (共著)
69.	2016/02	論文	Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases. (共著)
70.	2016/04	論文	A Retrospective 30 Years After Discovery of the EPR Effect of Solid Tumors: Next-Generation Chemotherapeutics and Photodynamic-therapy-Problems, Solutions, Prospects Microcirculation (共著)
71.	2016/05	論文	Missile-Type Tumor-Targeting Polymer Drug, P-THP, Seeks Tumors via Three Different Steps Based on the EPR Effect (共著)
72.	2016/06	論文	Styrene-maleic acid-copolymer conjugated zinc protoporphyrin as a candidate drug for tumor-targeted therapy and imaging. (共著)
73.	2016/12	論文	Pronounced Cellular Uptake of Pirarubicin versus That of Other Anthracyclines: Comparison of HPMA Copolymer Conjugates of Pirarubicin and Doxorubicin. Mol Pharm. (共著)
74.	2017/08	論文	Comparison of the pharmacological and biological properties of HPMA copolymer-pirarubicin conjugates: A single-chain copolymer conjugate and its biodegradable tandem-diblock copolymer conjugate. Eur J Pharm Sci. (共著)
75.	2017/09	論文	Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer. Biomaterials. (共著)
76.	2017/12	論文	Styrene maleic acid encapsulated raloxifene micelles for management of inflammatory bowel disease. Clin Transl Med. (共著)
77.	2018/01	論文	HPMA copolymer conjugate with pirarubicin: In vitro and ex vivo stability and drug release study. Int J Pharm. (共著)
78.	2018/09	論文	N-(2-hydroxypropyl)methacrylamide polymer conjugated pyropheophorbide-a, a promising tumor-targeted theranostic probe for photodynamic therapy and imaging. Eur J Pharm Biopharm. (共著)
79.	2018/12	論文	Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide-Generating Agents Improves the Therapeutic Effects of Nanomedicines. Mol Cancer Ther. (共著)
80.	2019/06	論文	Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors Photochem Photobiol Sci. 18 (6),1304-1314頁 (共著)
81.	2019/07	論文	Augmentation of EPR Effect and Efficacy of Anticancer Nanomedicine by Carbon Monoxide Generating Agents. Pharmaceutics. 11 (7),E343 (共著)
82.	2019/07	論文	Synthesis of Pegylated Manganese Protoporphyrin as a Catalase Mimic and Its Therapeutic Application to Acetaminophen-Induced Acute Liver Failure. 42 (7),1199-1206頁 (共著)
83.	2019/12	論文	Styrene-maleic acid copolymer-encapsulated carbon monoxide releasing molecule-2 (SMA/CORM-2) suppresses proliferation, migration and invasion of colorectal cancer cells in vitro and in vivo. Biochem Biophys Res Commun. 520 (2),320-326頁 (共著)
84.	2020/04	論文	Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization. Acta Biomater. 106,256-266頁 (共著)
85.	2020/07	論文	Extracts of Phellinus linteus, Bamboo (Sasa senanensis) Leaf and Chaga Mushroom (Inonotus obliquus) Exhibit Antitumor Activity through Activating Innate Immunity. Nutrients. 12 (8),2279 (共著)
86.	2020/07	論文	Moderating Role of Health Literacy on the Association between Alexithymia and Depressive Symptoms in Middle School Students. 17 (15),5321 (共著)
87.	2020/12	論文	Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers. Adv Drug Deliv Rev. 157,142-160頁 (共著)
88.	2020/12	論文	Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study. Pharmaceutics. 12 (12),1242 (共著)
89.	2021/01	論文	Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors. Expert Opin Drug Deliv.,1-24頁 (共著)
90.	2021/01	論文	Nano-designed carbon monoxide donor SMA/CORM2 exhibits protective effect against acetaminophen induced liver injury through macrophage reprograming and promoting liver regeneration. J Control Release. 331,350-363頁 (共著)
91.	2021/02	論文	Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis. Biomaterials. 269,120631 (共著)
92.	2021/03	論文	Tumor Environment-Responsive Hyaluronan Conjugated Zinc Protoporphyrin for Targeted Anticancer Photodynamic Therapy. J. Pers. Med. 11,136 (共著)
93.	2021/04	論文	Metabolic reprogramming of macrophages and its involvement in inflammatory diseases. 20,628-641頁 (共著)
94.	2021/05	論文	EPR-Effect Enhancers Strongly Potentiate Tumor-Targeted Delivery of Nanomedicines to Advanced Cancers: Further Extension to Enhancement of the Therapeutic Effect. J Pers Med. 11 (6),487 (共著)
95.	2021/05	論文	Unraveling the role of Intralipid in suppressing off-target delivery and augmenting the therapeutic effects of anticancer nanomedicines. Acta Biomater. 126,372-383頁 (共著)
96.	2021/07	論文	Development of a Selective Tumor-Targeted Drug Delivery System: Hydroxypropyl-Acrylamide Polymer-Conjugated Pirarubicin (P-THP) for Pediatric Solid Tumors. Cancers (Basel). 13 (15),3698 (共著)
97.	2021/08	論文	Interaction of smoking and being bullied on suicidal behaviors: a school-based cross-sectional survey in China. Environ Health Prev Med. 26 (1),79 (共著)
98.	2021/10	論文	Styrene Maleic Acid Copolymer-Based Micellar Formation of Temoporfin (SMA@ mTHPC) Behaves as A Nanoprobe for Tumor-Targeted Photodynamic Therapy with A Superior Safety. Biomedicines. 9 (10),1493 (共著)
99.	2021/11	論文	Inadequate Mental Health Literacy and Insufficient Physical Activity Potentially Increase the Risks of Anxiety and Depressive Symptoms in Chinese College Students. Front Psychiatry. 12,753695 (共著)
100.	2021/12	論文	Chronic cadmium exposure induces epithelial mesenchymal transition in prostate cancer cells through a TGF-β-independent, endoplasmic reticulum stress induced pathway. Toxicol Lett. 353,107 (共著)
101.	2021/12	論文	Expression Dynamics of Heme Oxygenase-1 in Tumor Cells and the Host Contributes to the Progression of Tumors. J Pers Med. 11 (12),1340 (共著)
102.	2021/12	論文	The Journey of an Outstanding Scientific Mind: Prof Hiroshi Maeda (1938-2021). J Pers Med. 11 (12),1362 (共著)
103.	2022/01	論文	EPR Effect-Based Tumor Targeted Nanomedicine: A Promising Approach for Controlling Cancer. J Pers Med. 12 (1),95 (単著)
104.	2022/01	論文	Nano-designed CO donor ameliorates bleomycin-induced pulmonary fibrosis via macrophage manipulation. J Control Release. 341,566 (共著)
105.	2022/01	論文	Patterns of six behaviors and psychosomatic symptoms in adolescents: A six-province study in China. J Affect Disord. 297,593 (共著)
106.	2022/02	論文	Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors. Expert Opin Drug Deliv. 19 (2),199 (共著)
107.	2022/02	論文	Mediating Effect of Sleep Disorder Between Low Mental Health Literacy and Depressive Symptoms Among Medical Students: The Roles of Gender and Grade. Front Psychiatry. 13,818295 (共著)
108.	2022/03	論文	Poly(styrene-co-maleic acid) Micelle of Photosensitizers for Targeted Photodynamic Therapy, Exhibits Prolonged Singlet Oxygen Generating Capacity and Superior Intracellular Uptake. J Pers Med. 12 (3),493 (共著)
109.	2022/03	論文	Treatment with Polyethylene Glycol-Conjugated Fungal D-Amino Acid Oxidase Reduces Lung Inflammation in a Mouse Model of Chronic Granulomatous Disease. Inflammation 45 (4),1668 (共著)
110.	2022/04	論文	Decrease of Hyaluronidase Activity and Suppression of Mouse CD4+ T Lymphocyte Activation by Tomato Juice Saponin Esculeoside B, and Its Sapogenol Esculeogenin B. J Pers Med. 12 (4),579 (共著)
111.	2022/04	論文	Tumor Stimulus-Responsive Biodegradable Diblock Copolymer Conjugates as Efficient Anti-Cancer Nanomedicines. J Pers Med. 12 (5),698 (共著)
112.	2022/05	論文	Nanoformulation of a carbon monoxide releasing molecule protects against cyclosporin A-induced nephrotoxicity and renal fibrosis via the suppression of the NLRP3 inflammasome mediated TGF-β/Smad pathway. Acta Biomater. 144,42 (共著)
113.	2022/05	論文	Singlet Oxygen In Vivo: It Is All about Intensity J Pers Med. 12 (6),891 (共著)
114.	2022/07	論文	Association Between the Patterns of Five Unhealthy Behaviors and Suicidal Behaviors Among Adolescents in Six Provinces of China. Front Psychiatry. 13,901537 (共著)
115.	2022/10	論文	Poly(Styrene-Co-Maleic Acid)-Conjugated 6-Aminofluorescein and Rhodamine Micelle as Macromolecular Fluorescent Probes for Micro-Tumors Detection and Imaging. J Pers Med. 12 (10),1650 (共著)
116.	2022/11	論文	Polymer nanomedicines with enzymatically triggered activation: A comparative study of in vitro and in vivo anti-cancer efficacy related to the spacer structure. Nanomedicine. 46,102597 (共著)
117.	2023/01	論文	HPMA copolymer conjugated 5-aminolevulinic acid exhibits superior efficacy for photodynamic therapy with tumor-responsive and targeting properties. Nanomedicine. 48,102636 (共著)