Faculty Information - Takechi Shinji

Takechi Shinji

Department / Course FACULTY OF PHARMACEUTICAL SCIENCES Department of Pharmaceutical Sciences

Job

Book and thesis
1.	2025/07	Papers	Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7 Journal of Biological Chemistry (Co-authored)
2.	2025/06	Papers	SDS-stable homo-oligomers of UDP-Glucuronosyltransferase 2B7: Involvement of disulfide bond formation via a specific cystein residue Drug Metabolism and Pharmacokinetics (Co-authored)
3.	2024/07	Papers	Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells The Journal of Toxicological Sciences,pp.313-319 (Co-authored)
4.	2024/05/30	Papers	Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling Nutrients,pp.1699-1699 (Co-authored)
5.	2023/05	Papers	Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products The Journal of Toxicological Sciences 48 (5),pp.263-272 (Co-authored)
6.	2022/09	Papers	Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells The Journal of Toxicological Sciences,pp.381-387 (Co-authored)
7.	2022/02	Papers	Use of a baculovirus-mammalian cell expression-system for expression of drug-metabolizing enzymes: optimization of infection with a focus on cytochrome P450 3A Frontiers in Pharmacology 13 (Co-authored)
8.	2020/10	Papers	The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35 (5),pp.466-474 (Co-authored)
9.	2020/07	Papers	The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. The Journal of Toxicological Sciences 45 (7),pp.401-409 (Co-authored)
10.	2019/10	Papers	β-Naphthoflavone , an exogenous ligand of aryl hydrocarbon receptor , disrupts zinc homeostasis in human hepatoma HepG2 cells. The Journal of Toxicological Sciences 44 (10),pp.711-720 (Co-authored)
11.	2019/07	Papers	Atypical Familial Amyotrophic Lateral Sclerosis with Slowly Progressing Lower Extremities-predominant Late-onset Muscular Weakness and Atrophy. Internal Medicine 58 (13),pp.1851-1858 (Co-authored)
12.	2016/11	Papers	Nrf2-ARE-dependent alterations in zinc transporter mRNA expression in HepG2 cells. PLoS ONE 11 (11),pp.e0166100 (Co-authored)
13.	2015/08	Papers	Identification of dihydropyrazine-glutathione adducts. J. Toxicol. Sci. 40 (4),pp.495-500 (Co-authored)
14.	2015/08	Papers	3-hydro-2,2,5,6-tetramethylpyrazine: a novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells. Arch. Biochem. Biophys. 580,pp.57-63 (Co-authored)
15.	2014/08	Papers	The effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine. J. Toxicol. Sci. 39 (4),pp.601-608 (Co-authored)
16.	2013/06	Papers	Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochimica et Biophysica Acta 1830 (6),pp.3616-3624 (Co-authored)
17.	2012/10	Papers	Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells. J. Toxicol. Sci. 37 (5),pp.1065-1069 (Co-authored)
18.	2012/05	Papers	Generation of radical species from dihydropyrazines having DNA strand-breakage activity and other characteristics. Chem. Pharm. Bull. 60 (5),pp.639-646 (Co-authored)
19.	2011/04	Papers	2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries J. Toxicol. Sci. 36 (2),pp.221-229 (Co-authored)
20.	2011/04	Papers	Glutathione depression by dihydropyrazine derivative. J. Toxicol. Sci. 36 (2),pp.231-235 (Co-authored)
21.	2011/01	Papers	The effects of tetraazaindene, derived from dihydropyrazine, to break DNA strands and inhibit bacterial growth. J. Basic Appl. Chem. 1,pp.1-7 (Co-authored)
22.	2010/07	Papers	Latent Enamine functionality of 5-methyl-2,3-dihydropyrazines. Chem. Pharm. Bull. 58 (7),pp.922-927 (Co-authored)
23.	2010/06	Papers	Phenyl-substituted dihydropyrazines with DNA strand-breakage activity Chem. Pharm. Bull. 58 (6),pp.825-828 (Co-authored)
24.	2010/03	Papers	Dihydropyrazine-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase. Biol. Pharm. Bull 33 (3),pp.379-383 (Co-authored)
25.	2009/12	Papers	Tetraazaindenes derived from dihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull 57 (12),pp.1371-1375 (Co-authored)
26.	2009/02	Papers	Oxidative stress induced by a dihydropyrazine derivative. BioI. Pharm. Bull 32 (2),pp.186-189 (Co-authored)
27.	2007/09	Papers	Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species on Escherichia coli. Biol. Pharm. Bull. 30 (9),pp.1663-1667 (Co-authored)
28.	2006/01	Papers	Mutation spectrum induced by dihydropyrazines in Escherichia coli. Biol. Pharm. Bull. 29 (1),pp.17-20 (Co-authored)
29.	2005/07	Papers	The role of dihydropyrazines upon the addition of Copper (II) in an accelerated death of Escherichia coli. Biol. Pharm. Bull. 28 (7),pp.1161-1164 (Co-authored)
30.	2005/03	Papers	Radical species in DNA strand-cleavage caused by dihydropyrazines. Biol.Pharm. Bull. 28 (3),pp.419-423 (Co-authored)
31.	2004/10	Papers	Familial amyotrophic lateral sclerosis with His46Arg mutation in Cu/Zn superoxide dismutase presenting characteristic clinical features and Lewy body-like hyaline inclusions. J. Neurol. Sci. 225 (1-2),pp.19-25 (Co-authored)
32.	2004/05	Papers	Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity. Mutat. Res. 560 (1),pp.49-55 (Co-authored)
33.	2002/11	Papers	Chicken HDAC2 down-regulates IgM light chain gene promoter activity. Biochem Biophys Res Commun. 299 (2),pp.263-267 (Co-authored)
34.	2002/09	Papers	Cloning and characterization of the chick Oct binding factor OBF-1. Biochim Biophys Acta. 1577 (3),pp.466-470 (Co-authored)
35.	2002/05	Papers	Clinical features and neuropathological findings of familial amyotrophic lateral sclerosis with a His46Arg mutation in Cu/Zn superoxide dismutase. J Neurol Sci. 197 (1-2),pp.73-78 (Co-authored)
36.	2000/08	Papers	Two novel mutations in the adrenoleukodystrophy gene in two unrelated Japanese families and the long-term effect of bone marrow transplantation. J Neurol Sci. 177 (2),pp.131-138 (Co-authored)
37.	2000/03	Papers	CALNUC (nucleobindin) is localized in the Golgi apparatus in insect cells. Eur J Cell Biol. 79 (3),pp.208-217 (Co-authored)
38.	1999/12	Papers	Sas3 is a histone acetyltransferase and requires a zinc finger motif. Biochem Biophys Res Commun. 266 (2),pp.405-410 (Co-authored)
39.	1996/04	Papers	Organizatoin of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences. DNA Res. 3 (2),pp.95-99 (Co-authored)
40.	1996/02	Papers	Molecular structure of the transposable element ninja in Drosophila simulans. Genes Genet Syst. 71 (1),pp.1-8 (Co-authored)
41.	1995/10	Papers	Initiation of unidirectional ColE2 DNA replication by a unique priming mechanism. Nucleic Acids Res. 23 (20),pp.4196-4201 (Co-authored)
42.	1995/10	Papers	Primer RNA synthesis by plasmid-specified Rep protein for initiation of ColE2 DNA replication. EMBO J. 14 (20),pp.5141-5147 (Co-authored)
43.	1994/07	Papers	Control of ColE2 plasmid replication: negative regulation of the expression of the plasmid-specified initiator protein, Rep, at a posttranscriptional step. Mol Gen Genet. 244 (1),pp.41-48 (Co-authored)
44.	1994/07	Papers	Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA. Mol Gen Genet. 244 (1),pp.49-56 (Co-authored)
45.	1994/03	Papers	Exogenous histone H1 injection into mitotic cells disrupts synchronous progression of mitotic events by delaying chromosome decondensation. J Cell Sci. 107,pp.693-701 (Co-authored)
46.	1993/09	Papers	Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair. Gene 131 (2),pp.193-199 (Co-authored)
47.	1993/04	Papers	The chicken histone gene family. Comp Biochem Physiol B. 104 (4),pp.635-639 (Co-authored)
48.	1993/01	Papers	Nucleotide sequence of the cDNA encoding mouse thyloid peroxidase. Gene 123 (2),pp.289-290 (Co-authored)
49.	1991/12	Papers	Nucleotide sequences of two members of the chicken H4 histone-encoding gene family. Gene 108 (2),pp.311-312 (Co-authored)