教員情報 - 武知　進士

タケチ　シンジ Takechi Shinji
武知　進士

所属薬学部薬学科

職種教授

著書・論文歴
1.	2025/11	論文	UDP-glucuronosyltransferase 1A9 function is mediated by the two C-terminal lysine residues and proper mobility/flexibility of the cytoplasmic tail Biochemical and Biophysical Research Communications,153004-153004頁 (共著)
2.	2025/10/01	論文	Dihydropyrazine activates the CAMKK2-AMPK-ULK1 signaling pathway in human hepatoma HepG2 cells The Journal of Toxicological Sciences 50 (10),577-582頁 (共著)
3.	2025/07	論文	Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7 Journal of Biological Chemistry (共著)
4.	2024/07	論文	Dihydropyrazine induces endoplasmic reticulum stress and inhibits autophagy in HepG2 human hepatoma cells The Journal of Toxicological Sciences 49 (7),313-319頁 (共著)
5.	2024/05/30	論文	Saponin Esculeoside A and Aglycon Esculeogenin A from Ripe Tomatoes Inhibit Dendritic Cell Function by Attenuation of Toll-like Receptor 4 Signaling Nutrients 16 (11),1699-1699頁 (共著)
6.	2023/05	論文	Oxidative stress and cellular toxicity induced by dihydropyrazine: a comparative study with other Maillard reaction products The Journal of Toxicological Sciences 48 (5),263-272頁 (共著)
7.	2022/09	論文	Dihydropyrazine suppresses TLR4-dependent inflammatory responses by blocking MAPK signaling in human hepatoma HepG2 cells The Journal of Toxicological Sciences 47 (9),381-387頁 (共著)
8.	2022/02	論文	Use of a baculovirus-mammalian cell expression-system for expression of drug-metabolizing enzymes: optimization of infection with a focus on cytochrome P450 3A Frontiers in Pharmacology 13 (共著)
9.	2021/11	論文	Molecular mechanism of dihydropyrazine-induced cytotoxicity: the possibility of an independent pathway from the receptor for advanced glycation end products. The Journal of toxicological sciences 46 (11),509-514頁 (共著)
10.	2021/11	論文	Functional Interaction between Cytochrome P450 and UDP-Glucuronosyltransferase on the Endoplasmic Reticulum Membrane: One of Post-translational Factors Which Possibly Contributes to Their Inter-Individual Differences. Biological & pharmaceutical bulletin 44 (11),1635-1644頁 (共著)
11.	2020/10	論文	The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9. Drug metabolism and pharmacokinetics 35 (5),466-474頁 (共著)
12.	2020/07	論文	The effect of dihydropyrazines on lipopolysaccharide-stimulated human hepatoma HepG2 cells via regulating the TLR4-MyD88-mediated NF-κB signaling pathway. The Journal of Toxicological Sciences 45 (7),401-409頁 (共著)
13.	2019/10	論文	β-Naphthoflavone , an exogenous ligand of aryl hydrocarbon receptor , disrupts zinc homeostasis in human hepatoma HepG2 cells. The Journal of Toxicological Sciences 44 (10),711-720頁 (共著)
14.	2019/07	論文	Atypical Familial Amyotrophic Lateral Sclerosis with Slowly Progressing Lower Extremities-predominant Late-onset Muscular Weakness and Atrophy. Internal Medicine 58 (13),1851-1858頁 (共著)
15.	2019/06	論文	雌マウス肝臓におけるセレン結合性タンパク質 (SelenBP)の発現と 2,3,7,8- tetrachlorodibenzo-p-dioxin 被誘導性: SelenBP1 欠損動物を用いた検討福岡医学雑誌 110 (2),128-132頁 (共著)
16.	2016/11	論文	Nrf2-ARE-dependent alterations in zinc transporter mRNA expression in HepG2 cells. PLoS ONE 11 (11),e0166100 (共著)
17.	2015/08	論文	Identification of dihydropyrazine-glutathione adducts. J. Toxicol. Sci. 40 (4),495-500頁 (共著)
18.	2015/08	論文	3-hydro-2,2,5,6-tetramethylpyrazine: a novel inducer of zinc transporter-1 in HepG2 human hepatocellular carcinoma cells. Arch. Biochem. Biophys. 580,57-63頁 (共著)
19.	2014/08	論文	The effect of dihydropyrazines on human hepatoma HepG2 cells: a comparative study using 2,3-dihydro-5,6-dimethylpyrazine and 3-hydro-2,2,5,6-tetramethylpyrazine. J. Toxicol. Sci. 39 (4),601-608頁 (共著)
20.	2013/06	論文	Selenium-binding protein 1: Its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Biochimica et Biophysica Acta 1830 (6),3616-3624頁 (共著)
21.	2012/10	論文	Possible involvement of glutathione balance disruption in dihydropyrazine-induced cytotoxicity on human hepatoma HepG2 cells. J. Toxicol. Sci. 37 (5),1065-1069頁 (共著)
22.	2012/05	論文	Generation of radical species from dihydropyrazines having DNA strand-breakage activity and other characteristics. Chem. Pharm. Bull. 60 (5),639-646頁 (共著)
23.	2011/04	論文	2,3,7,8-Tetrachlorodibenzo-p-dioxin potentially attenuates the gene expression of pituitary gonadotropin β-subunits in a fetal age-specific fashion: a comparative study using cultured pituitaries J. Toxicol. Sci. 36 (2),221-229頁 (共著)
24.	2011/04	論文	Glutathione depression by dihydropyrazine derivative. J. Toxicol. Sci. 36 (2),231-235頁 (共著)
25.	2011/01	論文	The effects of tetraazaindene, derived from dihydropyrazine, to break DNA strands and inhibit bacterial growth. J. Basic Appl. Chem. 1,1-7頁 (共著)
26.	2010/07	論文	Latent Enamine functionality of 5-methyl-2,3-dihydropyrazines. Chem. Pharm. Bull. 58 (7),922-927頁 (共著)
27.	2010/06	論文	Phenyl-substituted dihydropyrazines with DNA strand-breakage activity Chem. Pharm. Bull. 58 (6),825-828頁 (共著)
28.	2010/03	論文	Dihydropyrazine-induced inactivation of glyceraldehyde-3-phosphate dehydrogenase. Biol. Pharm. Bull 33 (3),379-383頁 (共著)
29.	2009/12	論文	Tetraazaindenes derived from dihydropyrazines with DNA strand-breakage activity. Chem. Pharm. Bull 57 (12),1371-1375頁 (共著)
30.	2009/02	論文	Oxidative stress induced by a dihydropyrazine derivative. BioI. Pharm. Bull 32 (2),186-189頁 (共著)
31.	2007/09	論文	Effects of phenyl derivatives of dihydropyrazines with ability to generate radical species on Escherichia coli. Biol. Pharm. Bull. 30 (9),1663-1667頁 (共著)
32.	2006/01	論文	Mutation spectrum induced by dihydropyrazines in Escherichia coli. Biol. Pharm. Bull. 29 (1),17-20頁 (共著)
33.	2005/07	論文	The role of dihydropyrazines upon the addition of Copper (II) in an accelerated death of Escherichia coli. Biol. Pharm. Bull. 28 (7),1161-1164頁 (共著)
34.	2005/03	論文	Radical species in DNA strand-cleavage caused by dihydropyrazines. Biol.Pharm. Bull. 28 (3),419-423頁 (共著)
35.	2004/10	論文	Familial amyotrophic lateral sclerosis with His46Arg mutation in Cu/Zn superoxide dismutase presenting characteristic clinical features and Lewy body-like hyaline inclusions. J. Neurol. Sci. 225 (1-2),19-25頁 (共著)
36.	2004/05	論文	Growth inhibition and mutagenesis induced in Escherichia coli by dihydropyrazines with DNA strand-cleaving activity. Mutat. Res. 560 (1),49-55頁 (共著)
37.	2002/11	論文	Chicken HDAC2 down-regulates IgM light chain gene promoter activity. Biochem Biophys Res Commun. 299 (2),263-267頁 (共著)
38.	2002/09	論文	Cloning and characterization of the chick Oct binding factor OBF-1. Biochim Biophys Acta. 1577 (3),466-470頁 (共著)
39.	2002/05	論文	Clinical features and neuropathological findings of familial amyotrophic lateral sclerosis with a His46Arg mutation in Cu/Zn superoxide dismutase. J Neurol Sci. 197 (1-2),73-78頁 (共著)
40.	2000/08	論文	Two novel mutations in the adrenoleukodystrophy gene in two unrelated Japanese families and the long-term effect of bone marrow transplantation. J Neurol Sci. 177 (2),131-138頁 (共著)
41.	2000/03	論文	CALNUC (nucleobindin) is localized in the Golgi apparatus in insect cells. Eur J Cell Biol. 79 (3),208-217頁 (共著)
42.	1999/12	論文	Sas3 is a histone acetyltransferase and requires a zinc finger motif. Biochem Biophys Res Commun. 266 (2),405-410頁 (共著)
43.	1996/04	論文	Organizatoin of the chicken histone genes in a major gene cluster and generation of an almost complete set of the core histone protein sequences. DNA Res. 3 (2),95-99頁 (共著)
44.	1996/02	論文	Molecular structure of the transposable element ninja in Drosophila simulans. Genes Genet Syst. 71 (1),1-8頁 (共著)
45.	1995/10	論文	Initiation of unidirectional ColE2 DNA replication by a unique priming mechanism. Nucleic Acids Res. 23 (20),4196-4201頁 (共著)
46.	1995/10	論文	Primer RNA synthesis by plasmid-specified Rep protein for initiation of ColE2 DNA replication. EMBO J. 14 (20),5141-5147頁 (共著)
47.	1994/07	論文	Control of ColE2 plasmid replication: negative regulation of the expression of the plasmid-specified initiator protein, Rep, at a posttranscriptional step. Mol Gen Genet. 244 (1),41-48頁 (共著)
48.	1994/07	論文	Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA. Mol Gen Genet. 244 (1),49-56頁 (共著)
49.	1994/03	論文	Exogenous histone H1 injection into mitotic cells disrupts synchronous progression of mitotic events by delaying chromosome decondensation. J Cell Sci. 107,693-701頁 (共著)
50.	1993/09	論文	Presence of particular transcription regulatory elements in the 5'-intergenic region shared by the chicken H2A-III and H2B-V pair. Gene 131 (2),193-199頁 (共著)
51.	1993/04	論文	The chicken histone gene family. Comp Biochem Physiol B. 104 (4),635-639頁 (共著)
52.	1993/01	論文	Nucleotide sequence of the cDNA encoding mouse thyloid peroxidase. Gene 123 (2),289-290頁 (共著)
53.	1991/12	論文	Nucleotide sequences of two members of the chicken H4 histone-encoding gene family. Gene 108 (2),311-312頁 (共著)
54.	2025/05	著書	予防薬学としての衛生薬学―健康と環境―［第5版］ (共著)
55.	2022/06	著書	予防薬学としての衛生薬学―健康と環境―［第4版］ (共著)
56.	2016/03	著書	予防薬学としての衛生薬学―健康と環境―［第3版］ (共著)
57.	2012/12	著書	予防薬学としての衛生薬学―健康と環境―［第2版］ (共著)
58.	1994/01	その他	Study on transcription regulation of the chicken histone gene families by gene targeting Nucleic Acids Sympo. 31 (共著)
59.	2003/08	その他	The characteristics of dihydropyrazines having DNA strand-breakage activity 19th International Congress of Heterocyclic Chemistry (共著)
60.	2004/09	その他	The chemical reactivities of dihydropyrazines derived from amino sugar XXIst European Colloquium on Heterocyclic Chemistry (共著)
61.	2005/12	その他	Phenyl-substituted dihydropyrazine derivatives possessing DNA strand-breaking activity The 2005 International Chemical Congress of Pacific Basin Societies (PACIFICHEM2005) (共著)
62.	2011/07	その他	Development synthesis of dihydropyrazines having DNA strand-breakage activity The 17th European Symposium on Organic Chemistry (ESOC 2011) (共著)