教員情報 - 上田　直子

ウエダ　ナオコ Ueda Naoko
上田　直子

所属薬学部薬学科

職種教授

著書・論文歴
1.	2022/06	論文	Effect of an intermolecular disulfide bond introduced into the first loop of CH1 domain of Adalimumab Fab on thermal stability and antigen-binding activity J.Biochem 172 (1),49-56頁 (共著)
2.	2021/06	論文	A comprehensive analysis of novel disulfide bond introduction site into the constant domain of human Fab Sci Rep. 11 (1),12937 (共著)
3.	2021/04	論文	Glycosylation decreases aggregation and immunogenicity of adalimumab fab secreted from Pichia pastoris J.Biochem 169 (4),435-443頁 (共著)
4.	2020/12	著書	遺伝子のクローニング法　（in コンパス　分子生物学　改訂第３版） (単著)
5.	2020/03	論文	Discovery of the Gene Encoding a Novel Small Serum Protein (SSP) of Protobothrops flavoviridis and the Evolution of SSPs Toxins 12,177 (共著)
6.	2020/03	論文	C-Terminal Cysteine PEGylation of Adalimumab Fab With an Engineered Interchain SS Bond Bio pharm bull 43 (3),418-423頁 (共著)
7.	2019/10	論文	Alternative mRNA splicing in three venom families underlying a possible production of divergent venom proteins of the Habu snake, Protobothrops flavoviridis Toxins(Basel) 11,581 (共著)
8.	2019/07	論文	Unique Structure (Construction and Configuration) and Evolution of the Array of Small Serum Protein Genes of Protobothrops flavoviridis Snake Biosci rep 39 (7),560 (共著)
9.	2019/02	論文	SDS-induced oligomerization of Lys⁴⁹-phospholipase A₂ from snake venom Sci Rep. (共著)
10.	2018/09	論文	Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab. Biochem Biophys Res Commun. 503 (2),752-756頁 (共著)
11.	2018/07	論文	The habu genome reveals accelerated evolution of venom protein genes. Sci Rep. 8 (1),11300 (共著)
12.	2018/01	論文	A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab. 495 (1),7-11頁 (共著)
13.	2016/10	著書	蛇毒成分の多様な生理機能と分子進化・遺伝子発現 (in ホルモンから見た生命現象と進化シリーズVII: 生体防御・社会性) ホルモンから見た生命現象と進化シリーズVII: 生体防御・社会性,１６０-１７５頁 (単著)
14.	2016/04	著書	ハブ毒を科学する：どうして毒成分はユニークで多様な機能を獲得したか (in ミルシル (自然と科学の情報誌）ミルシル (自然と科学の情報誌）９,１４-１６頁 (単著)
15.	2015/08	論文	Interisland variegation of venom [Lys⁴⁹]phospholipase A₂ isozyme genes in Protobothrops genus snakes in the southwestern islands of Japan. Toxicon (共著)
16.	2014/12	論文	The finding of a group IIE phospholipase A₂ gene in a specified segment of Protobothrops flavoviridis genome and its possible evolutionary relationship to group IIA phospholipase A2 genes. Toxins(Basel) (共著)
17.	2014/12	論文	Epithelium specific ETS transcription factor, ESE-3, of Protobothrops flavoviridis snake venom gland transactivates the promoters of venom phospholipase A₂ isozyme genes Toxicon 92,133-139頁 (共著)
18.	2014/08	論文	Discovery of a novel vascular endothelial growth factor (VEGF) with no affinity to heparin in Gloydius tsushimaensis venom Toxicon : official journal of the International Society on Toxinology 86,107-115頁 (共著)
19.	2013/12	論文	Suppression of severe lesions, myonecrosis and hemorrhage, caused by Protobothrops flavoviridis venom with its serum proteins 76,197 (共著)
20.	2013/01	論文	Structual characteristics and evolution of the Protobothrops elegans pancreatic phospholipase A₂ gene in contrast with those of Protobothrops genus venom phospholipase A₂ genes. Biosci. Biotechnol. Biochem 77,97-102頁 (共著)
21.	2012/06	論文	Comparative analysis of cells and proteins of pumplin plants for the control of fruit size. J. Biosci. Bioeng. 114,334-341頁 (共著)
22.	2012/03	論文	Structural characteristics and evolution of a novel venom phospholipase A₂ gene from Protobothrops flavoviridis. Biosci. Biotech. Biochem. 76,551-558頁 (共著)
23.	2011/05	論文	A [Lys⁴⁹] phospholipase A₂from Protobothrops flavoviridis venom induces caspase-independent apoptotic cell death accompanied by rapid plasma membrane rupture in human leukemia cells. Biosci. Biotech. Biochem. 75,864-870 (共著)
24.	2011/03	論文	Identification and evolution of venom phospholipase A₂ inhibitors from Protobothrops elegans serum. Biosci. Biotech. Biochem. 75,480-488 (共著)
25.	2010/04	論文	Unique structural characteristics and evolution of a cluster of venom phospholipase A₂ isozyme genes of Protobothrops flavoviridis snake. Gene 461,15-25 (共著)
26.	2009/09	論文	Island specific expression of a novel [Lys ⁴⁹ ]phospholipase A₂ (BPIII) in Protobothrops flavoviridis venom in Amami-Oshima,Japan Toxicon 54,399-407 (共著)
27.	2008/03	論文	Identification of the B subtype of gamma-phospholipase A₂ Inhibitor from Protobothrops flavoviridis serum and molecular evolution of snake serum phospholipase A₂Inhibitors. J. Mol. Evol. 66,298-307 (共著)
28.	2008/02	論文	Immunocytochemical demonstration of polyamines in nucleoli and nuclei. Histochem. Cell Biol 129,659-665 (共著)
29.	2006/11	論文	Discovery of novel [Arg⁴⁹]phospholipase A₂ isozymes from Protobothrops elegans venom and regional evolution of Crotalinae snake venom phospholipase A₂ isozymes in the southwestern islands of Japan and Taiwan. Toxicon : official journal of the International Society on Toxinology 48 (6),672-82 (共著)
30.	2005/08	論文	Amino acid sequence of a basic aspartate-49-phospholipase A₂ from Trimeresurus flavoviridis venom and phylogenetic analysis of Crotalinae venom phospholipases A₂. Toxicon : official journal of the International Society on Toxinology 46 (2),185-95 (共著)
31.	2005/01	論文	Molecular diversity and accelerated evolution of C-type lectin-like proteins from snake venom. Toxicon : official journal of the International Society on Toxinology 45 (1),1-14 (共著)
32.	2004/10	論文	ハブ毒を科学する（化学と生物第42巻　第10号) 化学と生物 42,687-693 (共著)
33.	2004	著書	表面プラズモン共鳴を用いた生体物質相互作用解析装置 (in ライフサイエンス系の機器分析) ライフサイエンス系の機器分析,180-190頁 (単著)
34.	2003/12	論文	Molecular evolution of myotoxic phospholipases A₂ from snake venom. Toxicon : official journal of the International Society on Toxinology 42 (8),841-54 (共著)
35.	2003/11	論文	Interisland mutation of a novel phospholipase A₂ from Trimeresurus flavoviridis venom and evolution of Crotalinae group II phospholipases A₂. Journal of molecular evolution 57 (5),546-54 (共著)
36.	2003/03	論文	Interisland evolution of Trimeresurus flavoviridis venom phospholipase A₂ isozymes. Journal of molecular evolution 56 (3),286-93 (共著)
37.	2003	論文	Case report: Extraocular muscle paresis caused by snakebite. The Kobe journal of medical sciences 49 (1-2),11-5 (共著)
38.	2002/09	論文	Flavoxobin, a serine protease from Trimeresurus flavoviridis (habu snake) venom, independently cleaves Arg726-Ser727 of human C3 and acts as a novel, heterologous C3 convertase. Immunology 107 (1),111-7 (共著)
39.	2001/10	論文	Trimeresurus flavoviridis (habu snake) venom induces human erythrocyte lysis through enzymatic lipolysis, complement activation and decreased membrane expression of CD55 and CD59. Pharmacology & toxicology 89 (4),188-94 (共著)
40.	2002	著書	Accelarated and regional evolution of snake venom gland isozymes Perspectives in Molecular Toxinology,387-400頁 (共著)
41.	2000/07	論文	Expression and secretion of scytalidopepsin B, an acid protease from Scytalidium lignicolum, in yeast. Bioscience, biotechnology, and biochemistry 64 (7),1542-6 (共著)
42.	1998/08	論文	Nucleotide sequence of the gene encoding the precursor protein of pepstatin insensitive acid protease B, scytalidopepsin B, from Scytalidium lignicolum Biosci Biotechnol Biochem 62,1637-1639頁 (共著)
43.	1997/08	論文	Glutathione-independent formaldehyde dehydrogenase from pseudomonas putida: Survey of functional groups with special regard for cysteine residues Biosci Biotechnol Biochem. 61,1354-1357頁 (共著)
44.	1996/07	論文	Nucleotide sequence of the gene encoding pepstatin-insensitive acid protease B, scytalidopepsin B, of Scytalidium lignicolum. Biosci Biotechnol Biochem. 60,1210-1211頁 (共著)
45.	1996/06	論文	DNA polymerases alpha and beta are required for DNA repair in an efficient nuclear extract from Xenopus oocytes 271,13816-13820頁 (共著)
46.	1996/06	論文	Arrested DNA replication in Xenopus and release by Escherichia coli mutagenesis proteins 272,1644 (共著)
47.	1996/07	論文	Nucleotide sequence of the gene encoding pepstatin-insensitive acid protease B, scytalidopepsin B, of Scytalidium lignicolum. Biosci Biotechnol Biochem. 60,1210-1211頁 (共著)
48.	1995/10	論文	Lysine-49-phospholipases A2 from Trimeresurus flavoviridis venom are membrane-acting enzymes 118,1037-1044頁 (共著)
49.	1995/08	論文	Regulation of the human erythropoietin receptor gene by proteins binding to GATA-1 and Sp1 motifs 23,3041-3049頁 (共著)
50.	1995/01	論文	Trimeresurus flavoviridis venom gland phospholipase A2 isozymes genes have evolved via accelerated substitutions 8,40-46頁 (共著)
51.	1994/04	論文	Darwinian evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes. 66,715-720頁 (共著)
52.	1993/01	論文	Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes 90,5964-5968頁 (共著)
53.	1993/08	論文	Purification, sequencing and characterization of single amino acid-substituted phospholipase A2 isozymes from Trimeresurus gramineus (green habu snake) venom. 31,957-967頁 (共著)
54.	1992/11	論文	Sequence determination and characterization of a phospholipase A2 isozyme from Trimeresurus gramineus (green habu snake) venom. 30,1331-1341頁 (共著)
55.	1992/10	論文	Refolding of Trimeresurus flavoviridis phospholipase A2 65 (10),2655-2659頁 (共著)
56.	1992/09	論文	Unusually high conservation of untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes. Proc Natl Acad Sci USA 89,8557-8561頁 (共著)
57.	1992/08	論文	Validity of putative calcium binding loops of photoprotein aequorin 307,272-274頁 (共著)
58.	1991/02	論文	Amino acid sequence of a phospholipase A2 from the venom of Trimeresurus gramineus (green habu snake) Toxicon 29,157-166頁 (共著)
59.	1990/11	論文	Cloning and sequence analysis of cDNA for Trimeresurus flavoviridis phospholipase A2, and consequent revision of the amino acid sequence. J. Biochem 10,816-821頁 (共著)
60.	1990/03	論文	Purification and amino acid sequence of basic protein II, a lysine-49-phospholipase A2 with low activity, from Trimeresurus flavoviridis venom. J Biochem 107,400-408頁 (共著)
61.	1989/12	論文	Investigation of an active site histidine-aspartate couple in Trimeresurus flavoviridis phospholipase A J Biochem 106,1054-1058頁 (共著)
62.	1988/06	論文	Transition of environmental polarity of tyrosine-76 of Trimeresurus flavoviridis phospholipase A2 upon active site ligand binding. J Mol Recognit. 1,124-129頁 (共著)
63.	1988/01	論文	Tryptophan residue essential for activity of Naja naja atra phospholipase A2. J Biochem. 103,156-161頁 (共著)
64.	1987/12	論文	Purification and characterization of phospholipase A₂ from Trimeresurus gramineus venom. J Biochem. 102,1441-1449頁 (共著)
65.	1986/12	論文	Interactions of Trimeresurus flavoviridis phospholipase A2 and its N-terminal octapeptide-removed and p-bromophenacylated derivatives with acridine and anilinonaphthalene dyes. J Biochem. 100,1551-1560頁 (共著)
66.	1993	その他	Multiple functions of Trimeresurus flavoviridis venom gland phospholipase A₂ isozymes have been acquired　by acceleratred evolution.　in Advances in Venom and　Toxin Research,95-102